Plasmonic Enhanced Reactive Oxygen Species Activation on Low‐Work‐Function Tungsten Nitride for Direct Near‐Infrared Driven Photocatalysis

For decades, the possibility to generate Reactive Oxygen Species (ROS) in biological systems through the use of light was mainly restricted to the photodynamic effect: the photoexcitation of molecules which then engage in charge- or energy-transfer to molecular oxygen (O2) to initiate ROS production. However, the classical photodynamic approach presents drawbacks, like per se chemical reactivity of the photosensitizing agent or fast molecular photobleaching due to in situ ROS generation, to name a few. Recently, a new approach, which promises many advantages, has entered the scene: plasmon-driven hot-electron chemistry. The effect takes advantage of the photoexcitation of plasmonic resonances in metal nanoparticles to induce a new cohort of photochemical and redox reactions. These metal photo-transducers are considered chemically inert and can undergo billions of photoexcitation rounds without bleaching or suffering significant oxidative alterations. Also, their optimal absorption band can be shape- and size-tailored in order to match any of the near infrared (NIR) biological windows, where undesired absorption/scattering are minimal. In this mini review, the basic mechanisms and principal benefits of this light-driven approach to generate ROS will be discussed. Additionally, some significant experiments in vitro and in vivo will be presented, and tentative new avenues for further research will be advanced.

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Near Infrared Light Triggered Reactive Oxygen Species Responsive Upconversion Nanoplatform for Drug Delivery and Photodynamic Therapy

European Journal of Inorganic Chemistry ◽

10.1002/ejic.201501320 ◽

2016 ◽

Vol 2016 (8) ◽

pp. 1206-1213 ◽

Cited By ~ 22

Author(s):

Ting Zhang ◽

Huiming Lin ◽

Liru Cui ◽

Na An ◽

Ruihan Tong ◽

...

Keyword(s):

Reactive Oxygen Species ◽

Drug Delivery ◽

Photodynamic Therapy ◽

Near Infrared ◽

Reactive Oxygen ◽

Infrared Light ◽

Oxygen Species ◽

Near Infrared Light

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Effect of red light and near infrared laser on the generation of reactive oxygen species in primary dermal fibroblasts

Journal of Photochemistry and Photobiology B Biology ◽

10.1016/j.jphotobiol.2018.09.004 ◽

2018 ◽

Vol 188 ◽

pp. 60-68 ◽

Cited By ~ 17

Author(s):

Sajan George ◽

Michael R. Hamblin ◽

Heidi Abrahamse

Keyword(s):

Reactive Oxygen Species ◽

Near Infrared ◽

Red Light ◽

Reactive Oxygen ◽

Infrared Laser ◽

Dermal Fibroblasts ◽

Oxygen Species

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Near Infrared-Activated Dye-Linked ZnO Nanoparticles Release Reactive Oxygen Species for Potential Use in Photodynamic Therapy

Materials ◽

10.3390/ma13010017 ◽

2019 ◽

Vol 13 (1) ◽

pp. 17 ◽

Cited By ~ 2

Author(s):

Jaspreet Singh Nagi ◽

Kenneth Skorenko ◽

William Bernier ◽

Wayne E. Jones ◽

Amber L. Doiron

Keyword(s):

Reactive Oxygen Species ◽

Photodynamic Therapy ◽

Near Infrared ◽

Umbilical Vein ◽

Particle Surface ◽

Reactive Oxygen ◽

Dependent Manner ◽

Oxygen Species ◽

Human Carcinoma ◽

Zno Particles

Novel dye-linked zinc oxide nanoparticles (NPs) hold potential as photosensitizers for biomedical applications due to their excellent thermal- and photo-stability. The particles produced reactive oxygen species (ROS) upon irradiation with 850 nm near infrared (NIR) light in a concentration- and time-dependent manner. Upon irradiation, ROS detected in vitro in human umbilical vein endothelial cells (HUVEC) and human carcinoma MCF7 cells positively correlated with particle concentration and interestingly, ROS detected in MCF7 was higher than in HUVEC. Preferential cytotoxicity was also exhibited by the NPs as cell killing was higher in MCF7 than in HUVEC. In the absence of irradiation, dye-linked ZnO particles minimally affected the viability of cell (HUVEC) at low concentrations (<30 μg/mL), but viability significantly decreased at higher particle concentrations, suggesting a need for particle surface modification with poly (ethylene glycol) (PEG) for improved biocompatibility. The presence of PEG on particles after dialysis was indicated by an increase in size, an increase in zeta potential towards neutral, and spectroscopy results. Cell viability was improved in the absence of irradiation when cells were exposed to PEG-coated, dye-linked ZnO particles compared to non-surface modified particles. The present study shows that there is potential for biological application of dye-linked ZnO particles in photodynamic therapy.

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