Photosensitizer coated upconversion nanoparticles for triggering reactive oxygen species under 980 nm near-infrared excitation

2019 ◽  
Vol 7 (46) ◽  
pp. 7306-7313 ◽  
Author(s):  
Jinhua Wu ◽  
Shanshan Du ◽  
Yuhua Wang
Keyword(s):  
Reactive Oxygen Species ◽  
Photodynamic Therapy ◽  
Rare Earth ◽  
Near Infrared ◽  
Reactive Oxygen ◽  
Great Promise ◽  
Upconversion Nanoparticles ◽  
Oxygen Species ◽  
Infrared Excitation

Rare-earth-based upconversion nanotechnology has recently shown great promise for photodynamic therapy (PDT).

scholarly journals Near Infrared-Activated Dye-Linked ZnO Nanoparticles Release Reactive Oxygen Species for Potential Use in Photodynamic Therapy

Materials ◽  
2019 ◽  
Vol 13 (1) ◽  
pp. 17 ◽  
Author(s):  
Jaspreet Singh Nagi ◽  
Kenneth Skorenko ◽  
William Bernier ◽  
Wayne E. Jones ◽  
Amber L. Doiron
Keyword(s):  
Reactive Oxygen Species ◽  
Photodynamic Therapy ◽  
Near Infrared ◽  
Umbilical Vein ◽  
Particle Surface ◽  
Reactive Oxygen ◽  
Dependent Manner ◽  
Oxygen Species ◽  
Human Carcinoma ◽  
Zno Particles

Novel dye-linked zinc oxide nanoparticles (NPs) hold potential as photosensitizers for biomedical applications due to their excellent thermal- and photo-stability. The particles produced reactive oxygen species (ROS) upon irradiation with 850 nm near infrared (NIR) light in a concentration- and time-dependent manner. Upon irradiation, ROS detected in vitro in human umbilical vein endothelial cells (HUVEC) and human carcinoma MCF7 cells positively correlated with particle concentration and interestingly, ROS detected in MCF7 was higher than in HUVEC. Preferential cytotoxicity was also exhibited by the NPs as cell killing was higher in MCF7 than in HUVEC. In the absence of irradiation, dye-linked ZnO particles minimally affected the viability of cell (HUVEC) at low concentrations (<30 μg/mL), but viability significantly decreased at higher particle concentrations, suggesting a need for particle surface modification with poly (ethylene glycol) (PEG) for improved biocompatibility. The presence of PEG on particles after dialysis was indicated by an increase in size, an increase in zeta potential towards neutral, and spectroscopy results. Cell viability was improved in the absence of irradiation when cells were exposed to PEG-coated, dye-linked ZnO particles compared to non-surface modified particles. The present study shows that there is potential for biological application of dye-linked ZnO particles in photodynamic therapy.

scholarly journals Mesoporous semiconductors combined with up-conversion nanoparticles for enhanced photodynamic therapy under near infrared light

RSC Advances ◽  
2019 ◽  
Vol 9 (30) ◽  
pp. 17273-17280 ◽  
Author(s):  
Fan Yang ◽  
Jun Liu ◽  
Xue Jiang ◽  
Weiwei Wu ◽  
Zhenni Wang ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Photodynamic Therapy ◽  
Tumor Cells ◽  
Near Infrared ◽  
Tumor Therapy ◽  
Reactive Oxygen ◽  
Infrared Light ◽  
Oxygen Species ◽  
Near Infrared Light

Photodynamic therapy (PDT) is a promising and effective method for tumor therapy that relies on the reactive oxygen species (ROS) produced by photosensitizers at specific wavelengths to inhibit tumor cells.

Near-infrared triggered generation of reactive oxygen species from upconverting nanoparticles decorated with an organoiridium complex

2016 ◽  
Vol 4 (18) ◽  
pp. 3113-3120 ◽  
Author(s):  
Joe Gerald Jesu Raj ◽  
Marta Quintanilla ◽  
Fiorenzo Vetrone
Keyword(s):  
Reactive Oxygen Species ◽  
Near Infrared ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Excitation Light ◽  
Infrared Excitation

We developed an upconverting nanoparticle capable of (up)converting near-infrared excitation light to UV to sensitize an organoiridium complex for the production of reactive oxygen species.

Reactive Oxygen Species Self-Sufficient Multifunctional Nanoplatform for Synergistic Chemo-Photodynamic Therapy with Red/Near-Infrared Dual-Imaging

2020 ◽  
Vol 3 (12) ◽  
pp. 9135-9144
Author(s):  
Yongkang Huang ◽  
De-E Liu ◽  
Jinxia An ◽  
Bingqing Liu ◽  
Liya Sun ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Photodynamic Therapy ◽  
Near Infrared ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Dual Imaging

NIR-triggered Biodegradable MOF-coated Upconversion Nanoparticles for Synergetic Chemodynamic/Photodynamic Therapy with Enhanced Efficacy

2021 ◽  
Author(s):  
Man Zou ◽  
Yajie Zhao ◽  
Binbin Ding ◽  
Fan Jiang ◽  
Yeqing Chen ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Photodynamic Therapy ◽  
Tumor Microenvironment ◽  
Visible Light ◽  
Penetration Depth ◽  
Reactive Oxygen ◽  
Upconversion Nanoparticles ◽  
Oxygen Species

The generation of reactive oxygen species (ROS) is often limited by the overexpression of glutathione (GSH) in the tumor microenvironment (TME) and the penetration depth of visible light. In view...

scholarly journals Photoactivated nanomotors via aggregation induced emission for enhanced phototherapy

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Shoupeng Cao ◽  
Jingxin Shao ◽  
Hanglong Wu ◽  
Shidong Song ◽  
Maria Teresa De Martino ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Photodynamic Therapy ◽  
Near Infrared ◽  
Radiant Energy ◽  
Reactive Oxygen ◽  
Infrared Light ◽  
Oxygen Species ◽  
Directed Motion ◽  
Aggregation Induced Emission

AbstractAggregation-induced emission (AIE) has, since its discovery, become a valuable tool in the field of nanoscience. AIEgenic molecules, which display highly stable fluorescence in an assembled state, have applications in various biomedical fields—including photodynamic therapy. Engineering structure-inherent, AIEgenic nanomaterials with motile properties is, however, still an unexplored frontier in the evolution of this potent technology. Here, we present phototactic/phototherapeutic nanomotors where biodegradable block copolymers decorated with AIE motifs can transduce radiant energy into motion and enhance thermophoretic motility driven by an asymmetric Au nanoshell. The hybrid nanomotors can harness two photon near-infrared radiation, triggering autonomous propulsion and simultaneous phototherapeutic generation of reactive oxygen species. The potential of these nanomotors to be applied in photodynamic therapy is demonstrated in vitro, where near-infrared light directed motion and reactive oxygen species induction synergistically enhance efficacy with a high level of spatial control.

scholarly journals CBIO-07. CELL DEATH INDUCED BY AN OSCILLATING MAGNETIC FIELD IN PATIENT DERIVED GLIOBLASTOMA CELLS IS MEDIATED BY REACTIVE OXYGEN SPECIES

2020 ◽  
Vol 22 (Supplement_2) ◽  
pp. ii17-ii17
Author(s):  
Shashank Hambarde ◽  
Martyn Sharpe ◽  
David Baskin ◽  
Santosh Helekar
Keyword(s):  
Reactive Oxygen Species ◽  
Cell Death ◽  
Cell Viability ◽  
Cortical Neurons ◽  
Reactive Oxygen ◽  
Great Promise ◽  
Antioxidant Vitamin ◽  
Ros Generation ◽  
Oxygen Species ◽  
Novel Therapy

Abstract Noninvasive cancer therapy with minimal side effects would be ideal for improving patient outcome in the clinic. We have developed a novel therapy using strong rotating magnets mounted on a helmet. They generate oscillating magnetic fields (OMF) that penetrate through the skull and cover the entire brain. We have demonstrated that OMF can effectively kill patient derived glioblastoma (GBM) cells in cell culture without having cytotoxic effects on cortical neurons and normal human astrocytes (NHA). Exposure of GBM cells to OMF reduced the cell viability by 33% in comparison to sham-treated cells (p&lt; 0.001), while not affecting NHA cell viability. Time lapse video-microscopy for 16 h after OMF exposure showed a marked elevation of mitochondrial reactive oxygen species (ROS), and rapid apoptosis of GBM cells due to activation of caspase 3. Addition of a potent antioxidant vitamin E analog Trolox effectively blocked OMF-induced GBM cell death. Furthermore, OMF significantly potentiated the cytotoxic effect of the pro-oxidant Benzylamine. The results of our studies demonstrate that OMF-induced cell death is mediated by ROS generation. These results demonstrate a potent oncolytic effect on GBM cells that is novel and unrelated to any previously described therapy, including a very different mechanism of action and different technology compared to Optune therapy. The effect is very powerful, and unlike Optune, can be seen within hours after initiation of treatment. We believe that this technology holds great promise for new, effective and nontoxic treatment of glioblastoma.

Plasmon-Mediated Generation of Reactive Oxygen Species from Near-Infrared Light Excited Gold Nanocages for Photodynamic Therapyin Vitro

ACS Nano ◽  
2014 ◽  
Vol 8 (7) ◽  
pp. 7260-7271 ◽  
Author(s):  
Liang Gao ◽  
Ru Liu ◽  
Fuping Gao ◽  
Yaling Wang ◽  
Xinglu Jiang ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Near Infrared ◽  
Reactive Oxygen ◽  
Infrared Light ◽  
Oxygen Species ◽  
Near Infrared Light ◽  
Gold Nanocages
Sign in / Sign up

Export Citation Format

Share Document