scholarly journals International amphibian micronucleus standardized procedure (ISO 21427-1) for in vivo evaluation of double-walled carbon nanotubes toxicity and genotoxicity in water

2011 ◽  
Vol 26 (2) ◽  
pp. 136-145 ◽  
Author(s):  
Florence Mouchet ◽  
Perine Landois ◽  
Vitaliy Datsyuk ◽  
Pascal Puech ◽  
Eric Pinelli ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
In Vivo Evaluation ◽  
Double Walled Carbon Nanotubes ◽  
Walled Carbon Nanotubes

scholarly journals Assessment of the Toxicity and Carcinogenicity of Double-Walled Carbon Nanotubes in the Rat Lung After Intratracheal Instillation: A Two-Year Study

2021 ◽  
Author(s):  
David Bedell Alexander ◽  
Dina Mourad Saleh ◽  
Shengyong Luo ◽  
Omnia Hosny Mohamed Ahmed ◽  
William T. Alexander ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Lung Tumor ◽  
Industrial Applications ◽  
Vehicle Control ◽  
Control Group ◽  
Rat Lung ◽  
Vehicle Control Group ◽  
Double Walled Carbon Nanotubes ◽  
Walled Carbon Nanotubes

Abstract Background Considering the expanding industrial applications of carbon nanotubes (CNTs), safety assessment of these materials is far less than needed. Very few long-term in vivo studies have been carried out. This is the first 2-year in vivo study to assess the effects of double walled carbon nanotubes (DWCNTs) in the lung and pleura of rats after pulmonary exposure. Methods Rats were divided into six groups: Untreated, Vehicle, 3 DWCNT groups (0.12mg/rat, 0.25mg/rat and 0.5mg/rat), and MWCNT-7 (0.5mg/rat). The test materials were administrated by intratracheal - intrapulmonary spraying (TIPS) every other day for 15 days. Rats were observed without further treatment until sacrifice at weeks 52 and 104. Results DWCNT were biopersistent in the rat lung and induced marked pulmonary inflammation with a significant increase in macrophage count and levels of the chemotactic cytokines CCL2 and CCL3. In addition, the 0.5 mg DWCNT treated rats had significantly higher pulmonary collagen deposition compared to the vehicle controls. The development of carcinomas in the lungs of rats treated with 0.5 mg DWCNT (4/24) was not quite statistically higher (p = 0.0502) than the vehicle control group (0/25), however, the overall incidence of lung tumor development, bronchiolo-alveolar adenoma and bronchiolo-alveolar carcinoma combined, in the lungs of rats treated with 0.5 mg DWCNT (7/24) was statistically higher (p < 0.05) than the vehicle control group (1/25). Notably, two of the rats treated with DWCNT, one in the 0.25 mg group and one in the 0.5mg group, developed pleural mesotheliomas. However, both of these lesions developed in the visceral pleura, and unlike the rats administered MWCNT-7, rats administered DWCNT did not have elevated levels of HMGB1 in their pleural lavage fluids. Conclusions Our results demonstrate that DWCNTs are biopersistent in the rat lung and induce chronic inflammation. Moreover, rats treated with 0.5 mg DWCNT developed pleural fibrosis. While our results do not show that DWCNT is carcinogenic in the rat lung, total tumor incidence was significantly increased in the 0.5 mg DWCNT group. Taken together, these findings demonstrate that the possibility that at least some types of DWCNTs are fibrogenic and carcinogenic cannot be ignored.

scholarly journals STRUCTURAL-FUNCTIONAL IN VIVO EVALUATION OF EFFECTS OF SINGLE-WALLED CARBON NANOTUBES AND COMPLEX OF VITAMINS A AND E ON THE LIVER IN RATS

2018 ◽  
Vol 97 (11) ◽  
pp. 1108-1113 ◽  
Author(s):  
Natalia N. Belyaeva ◽  
M. V. Vostrikova ◽  
A. V. Alekseeva ◽  
N. N. Demina ◽  
L. P. Sycheva
Keyword(s):  
Carbon Nanotubes ◽  
Single Walled Carbon Nanotubes ◽  
Fatty Degeneration ◽  
The Body ◽  
Design Stage ◽  
Single Exposure ◽  
In Vivo Evaluation ◽  
Single Walled Carbon ◽  
Walled Carbon Nanotubes

Introduction. A review of the literature on nanotechnology shows the advanced development of hygienic research in the field of nanotoxicology to be of fundamental importance, as it allows creating a basis for the introduction of safe production at the design stage of technological processes. The effects of carbon nanotubes (CNT) on the body are evaluated for the use in many different technical applications, including the alleged possibility of their use as a sorbing material in the water treatment process. Material and Methods. Two-weeks intragastric effect of single-walled carbon nanotubes (oUNT) at doses of 0.05 and 0.5 mg/kg and a complex of vitamins A and E (AE) at a dose of 25.3 mg/kg (vitamin E - 25.2 mg/kg and vitamin A - 0.1 mg/kg) on the liver of male Wistar rats, as well as in the same batch of animals three months after a two-week experiment and a single exposure to oUNT at a dose of 5mg/kg were studied in fifteen groups of animals. oUNT was dissolved in sunflower oil at the rate of 0.5 ml of oil per 100 g of body weight. Results. Two-weeks study of oUNT at doses of 0.05 and 0.5 mg/kg and three months after a single exposure at a dose of 5mg/kg revealed no damage to the nucleus of hepatocytes, but three months after a two-week experiment, when exposed to both doses of oUNT, showed a significant increase in this index, as well as indices of fatty degeneration, only in relation to groups of the two-week exposure. Thus, with two-weeks exposure of oUNT, three months after it, as well as three months after a single exposure at a dose of 5 mg/kg the fatty degeneration develops. The effect of the complex of vitamins AE in the two-weeks experiment and three months after it significantly worsens all the studied parameters in the rat liver, and with its complex effect with oUNT indices remain at the same changed level. Discussion. Probably UNT, getting into the digestive tract, cause pathological changes both in the place of direct contact - in the small intestine and in the remote body - the liver, which is consistent with both our data and previous studies. Conclusion. oUNT in different studied periods of exposure causes the development of fatty degeneration in the liver, and the use of vitamins A and E does not reduce the response of the liver damage.

Double-walled carbon nanotubes synthesized using carbon black as the dot carbon source

2006 ◽  
Vol 17 (13) ◽  
pp. 3100-3104 ◽  
Author(s):  
Zhi-Gang Chen ◽  
Feng Li ◽  
Wen-Cai Ren ◽  
Hongtao Cong ◽  
Chang Liu ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Carbon Source ◽  
Carbon Black ◽  
Double Walled Carbon Nanotubes ◽  
Walled Carbon Nanotubes

Covalent decoration onto the outer walls of double walled carbon nanotubes with perylenediimides

2015 ◽  
Vol 3 (19) ◽  
pp. 4960-4969 ◽  
Author(s):  
Myriam Barrejón ◽  
Sara Pla ◽  
Isadora Berlanga ◽  
María J. Gómez-Escalonilla ◽  
Luis Martín-Gomis ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Charge Separation ◽  
Transient Absorption ◽  
Femtosecond Transient Absorption ◽  
Covalently Bonded ◽  
Absorption Studies ◽  
Double Walled Carbon Nanotubes ◽  
Walled Carbon Nanotubes

Three new covalently bonded DWCNT–PDIs have been synthesized and characterized, showing exclusively functionalization of the outer walls leaving the inner walls intact. Femtosecond transient absorption studies were performed to seek evidence of charge separation in these hybrids.

Heat conduction in double-walled carbon nanotubes with intertube additional carbon atoms

2015 ◽  
Vol 17 (25) ◽  
pp. 16476-16482 ◽  
Author(s):  
Liu Cui ◽  
Yanhui Feng ◽  
Peng Tan ◽  
Xinxin Zhang
Keyword(s):  
Heat Transfer ◽  
Carbon Nanotubes ◽  
Heat Conduction ◽  
Heat Transfer Performance ◽  
Transfer Performance ◽  
Reduction Mechanisms ◽  
Double Walled Carbon Nanotubes ◽  
Walled Carbon Nanotubes

Theoretical insights into the heat transfer performance and its reduction mechanisms in double-walled carbon nanotubes with intertube additional carbon atoms.

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