Dioscorea nipponica Makino suppresses TPA ‐induced migration and invasion through inhibition of matrix metalloproteinase‐9 in human cervical cancer cells

2020 ◽  
Vol 35 (11) ◽  
pp. 1194-1201
Author(s):  
Chung‐Yuan Lee ◽  
Ying‐Erh Chou ◽  
Min‐Chien Hsin ◽  
Chiao‐Wen Lin ◽  
Po‐Hui Wang ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Matrix Metalloproteinase ◽  
Cancer Cells ◽  
Matrix Metalloproteinase 9 ◽  
Migration And Invasion ◽  
Dioscorea Nipponica Makino ◽  
Cervical Cancer Cells ◽  
Human Cervical Cancer Cells ◽  
Metalloproteinase 9 ◽  
Human Cervical Cancer

MicroRNA-10a targets CHL1 and promotes cell growth, migration and invasion in human cervical cancer cells

2012 ◽  
Vol 324 (2) ◽  
pp. 186-196 ◽  
Author(s):  
Mei-Jing Long ◽  
Fu-Xia Wu ◽  
Pu Li ◽  
Min Liu ◽  
Xin Li ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cell Growth ◽  
Cancer Cells ◽  
Migration And Invasion ◽  
Cervical Cancer Cells ◽  
Human Cervical Cancer Cells ◽  
Human Cervical Cancer

scholarly journals Silencing PROK2 Inhibits Invasion of Human Cervical Cancer Cells by Targeting MMP15 Expression

2020 ◽  
Vol 21 (17) ◽  
pp. 6391
Author(s):  
Min-Hua Wu ◽  
Pei-Ru Wu ◽  
Yi-Hsien Hsieh ◽  
Chia-Liang Lin ◽  
Chung-Jung Liu ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Survival Rate ◽  
Cancer Cells ◽  
Migration And Invasion ◽  
Overall Survival Rate ◽  
Potential Biomarker ◽  
Cervical Cancer Cells ◽  
Human Cervical Cancer Cells ◽  
Human Cervical Cancer

Cervical cancer is the second most frequent type of gynecologic cancer worldwide. Prokineticin 2 (PROK2) is reported to be involved in tumor progression in some malignant tumors. However, the role of PROK2 in the development of cervical cancer remains unknown. Our results indicate that PROK2 is overexpressed in the human cervical cancer. Cervical cancer patients with high PROK2 expression have a shorter overall survival rate (OS) and disease-free survival rate (DFS). PROK2 acts as a potential biomarker for predicting OS and DFS of cervical cancer patients. We further show that PROK2 is important factor for oncogenic migration and invasion in human cervical cancer cells. Knockdown PROK2 significantly inhibited cell migration, invasion, and MMP15 protein expression in HeLa cells. High expression of MMP15 is confirmed in the human cervical cancer, is significantly associated with the shorter overall survival rate (OS) and is correlated with PROK2 expression. Overexpression of PROK2 using PROK2 plasmid significantly reverses the function of knockdown PROK2, and further upregulates MMP15 expression, migration and invasion of human cervical cancer cells. In conclusion, our findings are the first to demonstrate the role of PROK2 as a novel and potential biomarker for clinical use, and reveal the oncogenic functions of PROK2 as therapeutic target for cervical cancer.

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