scholarly journals Single-dose systemic methotrexatevsexpectant management for treatment of tubal ectopic pregnancy: a placebo-controlled randomized trial

2017 ◽  
Vol 49 (2) ◽  
pp. 171-176 ◽  
Author(s):  
D. Jurkovic ◽  
M. Memtsa ◽  
E. Sawyer ◽  
A. N. A. Donaldson ◽  
A. Jamil ◽  
...  
Keyword(s):  
Single Dose ◽  
Randomized Trial ◽  
Ectopic Pregnancy ◽  
Tubal Ectopic Pregnancy

scholarly journals Predictors of Success of Repeated Injections of Single-dose Methotrexate Regimen for Tubal Ectopic Pregnancy

2006 ◽  
Vol 21 (1) ◽  
pp. 86 ◽  
Author(s):  
Geum Joon Cho ◽  
Sang Hoon Lee ◽  
Jin Woo Shin ◽  
Nak Woo Lee ◽  
Tak Kim ◽  
...  
Keyword(s):  
Single Dose ◽  
Ectopic Pregnancy ◽  
Predictors Of Success ◽  
Tubal Ectopic Pregnancy ◽  
Dose Methotrexate

scholarly journals Molecular therapy for ectopic pregnancy

2019 ◽  
Vol 2 (2) ◽  
pp. 38-39
Author(s):  
Agus Cakhantara ◽  
Aditya Prabawa
Keyword(s):  
Cell Death ◽  
Literature Review ◽  
Randomized Trial ◽  
Ectopic Pregnancy ◽  
Molecular Target ◽  
Therapeutic Use ◽  
Molecular Therapy ◽  
Tubal Ectopic Pregnancy ◽  
Placental Cell ◽  
Ectopic Pregnancies

Objective : To compare treatment in ectopic pregnancy within combination gefitinib, methotrexat and methotrexat only Method : Literature Review Result : Ectopic pregnancies are serious condition that can be fatal, therefore the prompt therapeutic is essential. There some recent studies explain molecular target therapeutic use combination of gefitinib and methotrexat is more effective inducing placental cell death and can rapidly resolve tubal ectopic pregnancy than methotrexate only. If a large clinical randomized trial confirm these finding, these combination could become a new medical option for ectopic pregnancy Conclusion : Combination gefitinib and methotrexate is more effective in ectopic pregnancy than methotrexate only

scholarly journals Cost-effectiveness analysis of different methods of treatment of tubal ectopic pregnancy in the south of Iran

2020 ◽  
Author(s):  
Bahia Namavar Jahromi ◽  
Elahe esmaili ◽  
Mozhgan Fardid ◽  
Jafari Abdosaleh ◽  
Zahra Kavosi ◽  
...  
Keyword(s):  
Single Dose ◽  
Cost Effectiveness ◽  
Incremental Cost ◽  
Ectopic Pregnancy ◽  
Cost Effective ◽  
Cost Utility ◽  
Double Dose ◽  
Tubal Ectopic Pregnancy ◽  
Dose Methotrexate ◽  
The Cost

Abstract Background: Ectopic pregnancy is one of the most important causes of maternal mortality and infertility that may impose many costs on patients. Today, Surgery and pharmaceutical treatments are the common methods of treating the disease. The aim of this study was to evaluate the cost-effectiveness of different methods of treating tubal ectopic pregnancy in the south of Iran.Methods: This study was an economic evaluation which analysed and compared the cost-effectiveness and cost-utility of three treatment methods, including single-dose methotrexate, double-dose methotrexate, and surgery in patients with tubal ectopic pregnancy. In this study, a decision tree model was used. The outcomes included in the model were the percentage of successful treatment and the average utility score of each treatment method. The study was conducted from the social perspective and a one-way and probabilistic sensitivity analysis was performed to measure the effects of uncertainty. The analysis of the collected data was performed using Excel and TreeAge software.Results: The incremental cost-effectiveness ratio of the surgery versus single-dose methotrexate was positive and equal to $5812 PPP; since it was less than the threshold, surgery was considered as a cost-effective method. The incremental cost-utility ratio also identified surgery as the best option. Moreover, the results of one-way showed the highest sensitivity to the effectiveness of single-dose methotrexate. Scatter plots also revealed that surgery in 82% and 96% of simulations was at the acceptable region compared with a single dose and double-dose methotrexate, respectively and below the threshold. It was identified as a more cost-effective strategy. Furthermore, the acceptability curves showed that in 81.4% of simulations, surgery was the most cost-effective treatment for thresholds less than 21011 PPP dollars.Conclusions: Based on the results of the present study, it is recommended that surgery can be used as the first line of treatment for ectopic. Also, the best drug strategy was single-dose methotrexate. Since these strategies reduce costs and increase treatment success and QALYs compared to double-dose methotrexate.

scholarly journals Changing Concept in the Management of Ectopic Pregnancy - A Case Report

2018 ◽  
Vol 8 (2) ◽  
pp. 73-75
Author(s):  
Sumana Rahman
Keyword(s):  
Single Dose ◽  
Case Report ◽  
Medical Treatment ◽  
Ectopic Pregnancy ◽  
Complete Resolution ◽  
Operative Procedure ◽  
Diagnostic Error ◽  
Conservative Approach ◽  
Tubal Ectopic Pregnancy ◽  
First Time

Ectopic pregnancy remains the great puzzle of gynaecology, no other pelvic condition gives rise to more diagnostic error like this condition. In the last 20 years, the management of ectopic pregnancy has evolved from a radical operative procedure to a more conservative approach. This case report describes a woman who experienced tubal ectopic pregnancy twice, with two different methods of management. In the first time she had left sided ruptured tubal ectopic pregnancy which was managed by laparoscopic left sided salphingectomy. In the next time, her right tube was involved with ectopic pregnancy. This time, she was decided to be managed by conservative medical treatment. The patient was treated with a single dose of injection methotrexate 50 mg intramuscularly. She was monitored closely at 4-5 days interval. At the 19th day, she was found to have complete resolution of the ectopic sac.J Shaheed Suhrawardy Med Coll, December 2016, Vol.8(2); 73-75

scholarly journals Success of medical management of tubal ectopic pregnancy with Methotrexate in a tertiary hospital in North India

2018 ◽  
Vol 7 (6) ◽  
pp. 2377
Author(s):  
Sunil K. Juneja ◽  
Kanupriya Jain
Keyword(s):  
Single Dose ◽  
Side Effects ◽  
Ectopic Pregnancy ◽  
Medical Management ◽  
Prospective Observational Study ◽  
Tertiary Hospital ◽  
North India ◽  
Tubal Ectopic Pregnancy ◽  
Factors Affecting ◽  
Serial Measurement

Background: Unruptured ectopic pregnancy can be managed with surgery as well as systemic methotrexate. We aimed to study efficacy of medical management and factors affecting success in strictly selected patients.Methods: It was a three-year prospective observational study. 171 patients with ectopic pregnancy were screened and those fulfilling the strict study criteria were given systemic methotrexate. The single dose regimen was followed. Patients were observed for side effects and signs of rupture. Serial measurement of HCG levels was done to determine success or failure. Various factors were studied which had potential bearing on results.Results: Thirty-one patients received methotrexate. We had an overall success rate of 93%. Two of the participants had surgery due to failure. No major side effects were observed.Conclusions: Carefully selected patients of unruptured ectopic pregnancy can be safely and successfully treated with systemic methotrexate.

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