A comparative Study of Mutations in Escherichia coli and Salmonella typhimurium shows that Codon Conservation is Strongly Correlated with Codon Usage

2000 ◽  
Vol 206 (2) ◽  
pp. 307-311 ◽  
Author(s):  
C. ALFF-STEINBERGER
Genetics ◽  
1998 ◽  
Vol 149 (1) ◽  
pp. 37-44 ◽  
Author(s):  
Xuhua Xia

Abstract The optimization of the translational machinery in cells requires the mutual adaptation of codon usage and tRNA concentration, and the adaptation of tRNA concentration to amino acid usage. Two predictions were derived based on a simple deterministic model of translation which assumes that elongation of the peptide chain is rate-limiting. The highest translational efficiency is achieved when the codon recognized by the most abundant tRNA reaches the maximum frequency. For each codon family, the tRNA concentration is optimally adapted to codon usage when the concentration of different tRNA species matches the square-root of the frequency of their corresponding synonymous codons. When tRNA concentration and codon usage are well adapted to each other, the optimal content of all tRNA species carrying the same amino acid should match the square-root of the frequency of the amino acid. These predictions are examined against empirical data from Escherichia coli, Salmonella typhimurium, and Saccharomyces cerevisiae.


2001 ◽  
Vol 268 (6) ◽  
pp. 1739-1748
Author(s):  
Aitor Hierro ◽  
Jesus M. Arizmendi ◽  
Javier De Las Rivas ◽  
M. Angeles Urbaneja ◽  
Adelina Prado ◽  
...  

2018 ◽  
Vol 54(8) ◽  
pp. 96
Author(s):  
Quyen, T.T.B. ◽  
Toan, H.T. ◽  
Tuan, N.T. ◽  
Thien, D.V.H. ◽  
Thanh, L.H.V. ◽  
...  

2011 ◽  
Vol 1 (1zero) ◽  
pp. 141 ◽  
Author(s):  
E. Oliverio ◽  
G. Finazzi ◽  
P. Daminelli ◽  
P. Monastero ◽  
P. Boni

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