scholarly journals The Role of the Right Anterior Prefrontal Cortex in Episodic Retrieval

NeuroImage ◽  
2000 ◽  
Vol 11 (3) ◽  
pp. 217-227 ◽  
Author(s):  
K. Allan ◽  
R.J. Dolan ◽  
P.C. Fletcher ◽  
M.D. Rugg
Keyword(s):  
Prefrontal Cortex ◽  
Episodic Retrieval ◽  
Anterior Prefrontal Cortex ◽  
The Right

Altered Resting-State Frontoparietal Control Network in Children with Attention-Deficit/Hyperactivity Disorder

2015 ◽  
Vol 21 (4) ◽  
pp. 271-284 ◽  
Author(s):  
Hsiang-Yuan Lin ◽  
Wen-Yih Isaac Tseng ◽  
Meng-Chuan Lai ◽  
Kayako Matsuo ◽  
Susan Shur-Fen Gau
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Prefrontal Cortex ◽  
Functional Connectivity ◽  
Resting State ◽  
Control Network ◽  
Children With Adhd ◽  
Hyperactivity Disorder ◽  
Anterior Prefrontal Cortex ◽  
The Right ◽  
Frontoparietal Control Network

AbstractThe frontoparietal control network, anatomically and functionally interposed between the dorsal attention network and default mode network, underpins executive control functions. Individuals with attention-deficit/hyperactivity disorder (ADHD) commonly exhibit deficits in executive functions, which are mainly mediated by the frontoparietal control network. Involvement of the frontoparietal control network based on the anterior prefrontal cortex in neurobiological mechanisms of ADHD has yet to be tested. We used resting-state functional MRI and seed-based correlation analyses to investigate functional connectivity of the frontoparietal control network in a sample of 25 children with ADHD (7–14 years; mean 9.94±1.77 years; 20 males), and 25 age-, sex-, and performance IQ-matched typically developing (TD) children. All participants had limited in-scanner head motion. Spearman’s rank correlations were used to test the associations between altered patterns of functional connectivity with clinical symptoms and executive functions, measured by the Conners’ Continuous Performance Test and Spatial Span in the Cambridge Neuropsychological Test Automated Battery. Compared with TD children, children with ADHD demonstrated weaker connectivity between the right anterior prefrontal cortex (PFC) and the right ventrolateral PFC, and between the left anterior PFC and the right inferior parietal lobule. Furthermore, this aberrant connectivity of the frontoparietal control network in ADHD was associated with symptoms of impulsivity and opposition-defiance, as well as impaired response inhibition and attentional control. The findings support potential integration of the disconnection model and the executive dysfunction model for ADHD. Atypical frontoparietal control network may play a pivotal role in the pathophysiology of ADHD. (JINS, 2015, 21, 271–284)

The role of the anterior prefrontal cortex in human cognition

Nature ◽  
10.1038/20178 ◽  
1999 ◽  
Vol 399 (6732) ◽  
pp. 148-151 ◽  
Author(s):  
Etienne Koechlin ◽  
Gianpaolo Basso ◽  
Pietro Pietrini ◽  
Seth Panzer ◽  
Jordan Grafman
Keyword(s):  
Prefrontal Cortex ◽  
Human Cognition ◽  
Anterior Prefrontal Cortex

Frontal Brain Activity during Episodic and Semantic Retrieval: Insights from Event-Related Potentials

1999 ◽  
Vol 11 (6) ◽  
pp. 598-609 ◽  
Author(s):  
Charan Ranganath ◽  
Ken A. Paller
Keyword(s):  
Prefrontal Cortex ◽  
Memory Retrieval ◽  
Brain Activity ◽  
Novelty Detection ◽  
Event Related Potentials ◽  
Episodic Retrieval ◽  
Semantic Retrieval ◽  
Retrieval Task ◽  
Related Potentials ◽  
The Right

Previous neuropsychological and neuroimaging results have implicated the prefrontal cortex in memory retrieval, although its precise role is unclear. In the present study, we examined patterns of brain electrical activity during retrieval of episodic and semantic memories. In the episodic retrieval task, participants retrieved autobiographical memories in response to event cues. In the semantic retrieval task, participants generated exemplars in response to category cues. Novel sounds presented intermittently during memory retrieval elicited a series of brain potentials including one identifiable as the P3a potential. Based on prior research linking P3a with novelty detection and with the frontal lobes, we predicted that P3a would be reduced to the extent that novelty detection and memory retrieval interfere with each other. Results during episodic and semantic retrieval tasks were compared to results during a task in which subjects attended to the auditory stimuli. P3a amplitudes were reduced during episodic retrieval, particularly at right lateral frontal scalp locations. A similar but less lateralized pattern of frontal P3a reduction was observed during semantic retrieval. These findings support the notion that the right prefrontal cortex is engaged in the service of memory retrieval, particularly for episodic memories.

scholarly journals Interpersonal Synchrony Special Issue The role of anterior prefrontal cortex (area 10) in face-to-face deception measured with fNIRS

2020 ◽  
Author(s):  
Paola Pinti ◽  
Andrea Devoto ◽  
Isobel Greenhalgh ◽  
Ilias Tachtsidis ◽  
Paul W Burgess ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Near Infrared ◽  
Brain Activity ◽  
Lie Detection ◽  
Brain Activation ◽  
Functional Near Infrared Spectroscopy ◽  
Face To Face ◽  
Interpersonal Synchrony ◽  
Anterior Prefrontal Cortex

Abstract Anterior prefrontal cortex (PFC, Brodmann area 10) activations are often, but not always, found in neuroimaging studies investigating deception, and the precise role of this area remains unclear. To explore the role of the PFC in face-to-face deception, we invited pairs of participants to play a card game involving lying and lie detection while we used functional near infrared spectroscopy (fNIRS) to record brain activity in the PFC. Participants could win points for successfully lying about the value of their cards or for detecting lies. We contrasted patterns of brain activation when the participants either told the truth or lied, when they were either forced into this or did so voluntarily and when they either succeeded or failed to detect a lie. Activation in the anterior PFC was found in both lie production and detection, unrelated to reward. Analysis of cross-brain activation patterns between participants identified areas of the PFC where the lead player’s brain activity synchronized their partner’s later brain activity. These results suggest that during situations that involve close interpersonal interaction, the anterior PFC supports processing widely involved in deception, possibly relating to the demands of monitoring one’s own and other people’s behaviour.

scholarly journals Reducing future fears by suppressing the brain mechanisms underlying episodic simulation

2016 ◽  
Vol 113 (52) ◽  
pp. E8492-E8501 ◽  
Author(s):  
Roland G. Benoit ◽  
Daniel J. Davies ◽  
Michael C. Anderson
Keyword(s):  
Prefrontal Cortex ◽  
Dorsolateral Prefrontal Cortex ◽  
Ventromedial Prefrontal Cortex ◽  
Episodic Simulation ◽  
Dorsolateral Prefrontal ◽  
Future Events ◽  
The Right ◽  
Development Of Anxiety ◽  
The Brain

Imagining future events conveys adaptive benefits, yet recurrent simulations of feared situations may help to maintain anxiety. In two studies, we tested the hypothesis that people can attenuate future fears by suppressing anticipatory simulations of dreaded events. Participants repeatedly imagined upsetting episodes that they feared might happen to them and suppressed imaginings of other such events. Suppressing imagination engaged the right dorsolateral prefrontal cortex, which modulated activation in the hippocampus and in the ventromedial prefrontal cortex (vmPFC). Consistent with the role of the vmPFC in providing access to details that are typical for an event, stronger inhibition of this region was associated with greater forgetting of such details. Suppression further hindered participants’ ability to later freely envision suppressed episodes. Critically, it also reduced feelings of apprehensiveness about the feared scenario, and individuals who were particularly successful at down-regulating fears were also less trait-anxious. Attenuating apprehensiveness by suppressing simulations of feared events may thus be an effective coping strategy, suggesting that a deficiency in this mechanism could contribute to the development of anxiety.

The role of anterior prefrontal cortex in adolescents prone to psychosis

2011 ◽  
Vol 26 ◽  
pp. e52
Author(s):  
Annalaura Lagioia ◽  
Martin Debbane ◽  
Maude Schneider ◽  
Stephan Eliez
Keyword(s):  
Prefrontal Cortex ◽  
Anterior Prefrontal Cortex

scholarly journals Integration in Working Memory: A Magnetic Stimulation Study on the Role of Left Anterior Prefrontal Cortex

PLoS ONE ◽  
2012 ◽  
Vol 7 (8) ◽  
pp. e43731 ◽  
Author(s):  
Nicola De Pisapia ◽  
Marco Sandrini ◽  
Todd S. Braver ◽  
Luigi Cattaneo
Keyword(s):  
Working Memory ◽  
Prefrontal Cortex ◽  
Magnetic Stimulation ◽  
Anterior Prefrontal Cortex

Causal Role of the Dorsolateral Prefrontal Cortex in Belief Updating under Uncertainty

2020 ◽  
Vol 31 (1) ◽  
pp. 184-200
Author(s):  
Stefan Schulreich ◽  
Lars Schwabe
Keyword(s):  
Prefrontal Cortex ◽  
Dorsolateral Prefrontal Cortex ◽  
Causal Role ◽  
Uncertain Environments ◽  
Belief Updating ◽  
Frontoparietal Network ◽  
Dorsolateral Prefrontal ◽  
The Right ◽  
Normative Value

Abstract Adaptive performance in uncertain environments depends on the ability to continuously update internal beliefs about environmental states. Recent correlative evidence suggests that a frontoparietal network including the dorsolateral prefrontal cortex (dlPFC) supports belief updating under uncertainty, but whether the dlPFC serves a “causal” role in this process is currently not clear. To elucidate its contribution, we leveraged transcranial direct current stimulation (tDCS) over the right dlPFC, while 91 participants performed an incentivized belief-updating task. Participants also underwent a psychosocial stress or control manipulation to investigate the role of stress, which is known to modulate dlPFC functioning. We observed enhanced monetary value updating after anodal tDCS when it was normatively expected from a Bayesian perspective. A model-based analysis indicates that this effect was driven by belief updating. However, we also observed enhanced non-normative value updating, which might have been driven instead by expectancy violation. Enhanced normative and non-normative value updating reflected increased vs. decreased Bayesian rationality, respectively. Furthermore, cortisol increases were associated with enhanced positive, but not with negative, value updating. The present study thereby sheds light on the causal role of the right dlPFC in the remarkable human ability to navigate uncertain environments by continuously updating prior knowledge following new evidence.

The Role of the Dorsal–Lateral Prefrontal Cortex in Reward Sensitivity During Approach–Avoidance Conflict

2021 ◽  
Author(s):  
Camarin E Rolle ◽  
Mads L Pedersen ◽  
Noriah Johnson ◽  
Ken-ichi Amemori ◽  
Maria Ironside ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Avoidance Behavior ◽  
Reward Sensitivity ◽  
Diffusion Modeling ◽  
Dorsolateral Prefrontal ◽  
Current Task ◽  
Approach Avoidance ◽  
Cortical Regions ◽  
The Right

Abstract Approach–Avoidance conflict (AAC) arises from decisions with embedded positive and negative outcomes, such that approaching leads to reward and punishment and avoiding to neither. Despite its importance, the field lacks a mechanistic understanding of which regions are driving avoidance behavior during conflict. In the current task, we utilized transcranial magnetic stimulation (TMS) and drift-diffusion modeling to investigate the role of one of the most prominent regions relevant to AAC—the dorsolateral prefrontal cortex (dlPFC). The first experiment uses in-task disruption to examine the right dlPFC’s (r-dlPFC) causal role in avoidance behavior. The second uses single TMS pulses to probe the excitability of the r-dlPFC, and downstream cortical activations, during avoidance behavior. Disrupting r-dlPFC during conflict decision-making reduced reward sensitivity. Further, r-dlPFC was engaged with a network of regions within the lateral and medial prefrontal, cingulate, and temporal cortices that associate with behavior during conflict. Together, these studies use TMS to demonstrate a role for the dlPFC in reward sensitivity during conflict and elucidate the r-dlPFC’s network of cortical regions associated with avoidance behavior. By identifying r-dlPFC’s mechanistic role in AAC behavior, contextualized within its conflict-specific downstream neural connectivity, we advance dlPFC as a potential neural target for psychiatric therapeutics.

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