Endocrine Changes in Male Patients with Obstructive Sleep Apnea

Background.One of the main hypotheses on the development of daytime sleepiness (ES) is increased arousal in obstructive sleep apnea (OSA). Cyclic alternating pattern (CAP) is considered to be the main expression of sleep microstructure rather than arousal. Therefore, we aimed to investigate whether there is any difference between OSA patients with versus without ES in terms of the parameters of sleep macro- and microstructure and which variables are associated with Epworth Sleepiness Scale (ESS) score.Methods.Thirty-eight male patients with moderate to severe OSA were divided into two subgroups by having been used to ESS as ES or non-ES.Results.There was no difference between two groups in clinical characteristics and macrostructure parameters of sleep. However, ES group had significantly higher CAP rate, CAP duration, number of CAP cycles, and duration and rate of the subtypes A2 (p=0.033, 0.019, 0.013, and 0.019, respectively) and lower mean phase B duration(p=0.028)compared with non-ES group. In correlation analysis, ESS score was not correlated with any CAP measure.Conclusions.OSA patients with ES have increased CAP measures rather than those without ES.

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Collar Size as Predictor of Obstructive Sleep Apnea

Philippine Journal of Otolaryngology Head and Neck Surgery ◽

10.32412/pjohns.v23i2.727 ◽

2008 ◽

Vol 23 (2) ◽

pp. 14-16

Author(s):

Lyra V. Veloro ◽

Michael Alexius A. Sarte ◽

Samantha S. Castañeda

Keyword(s):

Body Mass Index ◽

Obstructive Sleep Apnea ◽

Sleep Apnea ◽

Body Mass ◽

Neck Circumference ◽

Normal Group ◽

Physical Measurements ◽

Obstructive Sleep ◽

Male Patients ◽

The Mean

Objective: This study focuses on evaluating the relationship between physical findings, particularly collar size and Body Mass Index (BMI), and polysomnographic parameters in male patients seen at a Sleep Disorders Laboratory, suspected to have Obstructive Sleep Apnea (OSA). Methods: Design: Cross-sectional study Setting: Academic tertiary private hospital Participants: Charts of 149 adult male patients referred for polysomnography between July 1, 2005 and June 30, 2006 were reviewed. Height, weight, and external neck circumference measurements were obtained. The data from polysomnography results were noted and correlated with the physical measurements. Results: The mean collar size for the OSA group was 42.03 cm with a mean BMI of 29.14 while the mean collar size for the normal group was 39.05 cm with a mean BMI of 25.36. A significant difference was noted in both the collar size and body mass index (BMI) between the OSA group and the normal group (p<0.005). Results showed a significant correlation between collar size and BMI. Collar size and BMI measurements were also correlated with increasing severity of sleep apnea in the OSA group. The ³40 cm collar size among male adults with symptoms of OSA was 80% sensitive and 67% specific with a positive predictive value of 94% in predicting true OSA. Conclusion: This study suggests that the external neck circumference and the degree of obesity determined through BMI measurement may be important predictors of sleep apnea in adult Filipino males suspected to have OSA. Given the high probability of having true OSA in symptomatic male adults with a collar size ³ 40 cm, outright definitive management may be opted for in these patients, while those with a collar size < 40 cm may need to undergo further confirmatory tests. Keywords: obstructive sleep apnea, external neck circumference, collar size, body mass index, polysomnography, obesity

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Sleep and Nocturia in Under Age 50 Male Patients with Obstructive Sleep Apnea Syndrome

Journal of Sleep Medicine ◽

10.13078/jsm.200009 ◽

2020 ◽

Vol 17 (1) ◽

pp. 78-83

Author(s):

Yeon Hak Chung ◽

Su Jung Choi ◽

Jae Rim Kim ◽

Jaehong Park ◽

Eun Yeon Joo

Keyword(s):

Obstructive Sleep Apnea ◽

Sleep Apnea ◽

Obstructive Sleep Apnea Syndrome ◽

Sleep Apnea Syndrome ◽

Obstructive Sleep ◽

Male Patients ◽

Apnea Syndrome

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sVAP-1 and Adropin Levels in Male Patients With Obstructive Sleep Apnea: Likely Predictions of Endothelial Dysfunction and Severity of Disease

10.21203/rs.3.rs-448976/v1 ◽

2021 ◽

Author(s):

Yuehong Liu ◽

Zhongyu Kong ◽

Song Shi

Keyword(s):

Obstructive Sleep Apnea ◽

Sleep Apnea ◽

Endothelial Dysfunction ◽

Multivariate Regression Analysis ◽

Vital Role ◽

Inflammatory Factors ◽

Obstructive Sleep ◽

Tnf Α ◽

Male Patients ◽

And Control

Abstract Background: The main purpose of this study was to determine sVAP-1 levels in patients with moderate and severe obstructive sleep apnea (OSA) compared with healthy controls, and further determine the relationship between sVAP-1 concentration and biomarkers of vascular endothelial dysfunction (ED), including adropin and inflammatory factors.Methods: In this study, we included 50 male patients with OSA (25 moderate and 25 severe) and 20 age- and sex-matched control subjects. The OSA patients underwent polysomnography and all subjects underwent fasting sampling of peripheral blood for laboratory analyses.Results: Serum sVAP-1 levels and inflammatory biomarkers (IL-6, TNF-α, hsCRP) were significantly higher in patients with severe OSA in comparison with the moderate OSA and control groups, whereas plasma adropin levels presented a completely reverse trend. Moreover, sVAP-1 levels were in significant positive correlation with levels of AHI, ODI, TNF-α, IL-6 and hsCRP. However, it was significantly negative correlated with adropin levels. Receiver Operating Characteristic (ROC) analysis showed that AUC for sVAP-1levels in predicting OSA was 0.876 (P <.001,95% CI 0.784−0.968). Serum sVAP-1 cutoff value more than 445.5ng/mL provided 88% sensitivity and 80% specificity for the detection of OSA status. A multivariate regression analysis showed that sVAP-1 remained as a significant positive predictor of severe OSA status.Conclusions: Serum sVAP-1 concentration significantly correlates with indices of OSA severity and biomarkers of ED, suggesting that sVAP-1 plays a vital role in the pathophysiology of ED-related diseases.

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