General Principles for the Regeneration of Bone and Cartilage

2012 ◽  
pp. 69-88
Author(s):  
Michael Jagodzinski ◽  
C. Haasper
Keyword(s):  
Regeneration Of Bone ◽  
And Cartilage

scholarly journals Platelet-rich plasma. Evidenze, limiti e prospettive future

2019 ◽  
Vol 33 (3) ◽  
pp. 220-225
Author(s):  
A. Bove ◽  
B. Russo ◽  
F. Traficante ◽  
A. Barile ◽  
N. Orabona
Keyword(s):  
Regenerative Medicine ◽  
Clinical Research ◽  
Basic Science ◽  
Biological Therapy ◽  
Scientific Literature ◽  
Platelet Rich Plasma ◽  
Biological Pathways ◽  
Tissue Healing ◽  
Regeneration Of Bone ◽  
And Cartilage

Abstract Regenerative medicine is a promising frontier in several fields of medicine and surgery. In orthopaedics, cell products are used to facilitate the regeneration of bone, tendons, and cartilage in many orthopaedic disorders. A large portion of scientific literature is developing while basic science provides further information on tissue healing and the biological pathways to enhance it. PRP is one of the most promising products used as biological therapy. Even though a standardised methodology of preparation and utilisation is still missing, promising results coming from clinical research encourage its use. Further research will meet the challenge of standardising procedures, timing and way of application, and outcomes reporting, so as to allow researcher to make analyses and comparisons that will expand our knowledge of this interesting field of medicine.

Gene therapy for repair and regeneration of bone and cartilage

2018 ◽  
Vol 40 ◽  
pp. 59-66 ◽  
Author(s):  
Matthew W Grol ◽  
Brendan H Lee
Keyword(s):  
Gene Therapy ◽  
Regeneration Of Bone ◽  
And Cartilage

scholarly journals A Pilot Study of Seamless Regeneration of Bone and Cartilage in Knee Joint Regeneration Using Honeycomb TCP

Materials ◽  
2021 ◽  
Vol 14 (23) ◽  
pp. 7225
Author(s):  
Kiyofumi Takabatake ◽  
Hidetsugu Tsujigiwa ◽  
Aki Yoshida ◽  
Takayuki Furumatsu ◽  
Hotaka Kawai ◽  
...  
Keyword(s):  
Knee Joint ◽  
Tissue Regeneration ◽  
Transforming Growth Factor ◽  
Cartilage Tissue ◽  
Tissue Formation ◽  
Hard Tissue ◽  
Defect Model ◽  
Regeneration Of Bone ◽  
Bone Tissue Formation ◽  
And Cartilage

The knee joint is a continuous structure of bone and cartilage tissue, making it difficult to regenerate using artificial biomaterials. In a previous study, we succeeded in developing honeycomb tricalcium phosphate (TCP), which has through-and-through holes and is able to provide the optimum microenvironment for hard tissue regeneration. We demonstrated that TCP with 300 μm pore diameters (300TCP) induced vigorous bone formation, and that TCP with 75 μm pore diameters (75TCP) induced cartilage formation. In the present study, we regenerated a knee joint defect using honeycomb TCP. 75TCP and 300TCP were loaded with transforming growth factor (TGF)-β alone or bone morphogenic protein (BMP)-2+TGF-β with or without Matrigel and transplanted into knee joint defect model rabbits. 75TCP showed no bone or cartilage tissue formation in any of the groups with TGF-β alone and BMP-2+TGF-β with/without Matrigel. However, for 300TCP and BMP-2+TGF-β with or without Matrigel, vigorous bone tissue formation was observed in the TCP holes, and cartilage tissue formation in the TCP surface layer was continuous with the existing cartilage. The cartilage area in the TCP surface was larger in the group without Matrigel (with BMP-2+TGF-β) than in the group with Matrigel (with BMP-2+TGF-β). Therefore, honeycomb TCP can induce the seamless regeneration of bone and cartilage in a knee joint.

scholarly journals Features of regeneration of bone and cartilage tissue after traumatic intraarticular damage (experimental study)

TRAUMA ◽  
2018 ◽  
Vol 19 (6) ◽  
pp. 80-86
Author(s):  
I.G. Bets ◽  
N.O. Ashukina ◽  
V.Ye. Maltseva ◽  
O.A. Nikolchenko
Keyword(s):  
Experimental Study ◽  
Cartilage Tissue ◽  
Regeneration Of Bone ◽  
And Cartilage

Cytokine synergy, collagenases and cartilage collagen breakdown

2003 ◽  
Vol 70 ◽  
pp. 125-133 ◽  
Author(s):  
Tim E. Cawston ◽  
Jenny M. Milner ◽  
Jon B. Catterall ◽  
Andrew D. Rowan
Keyword(s):  
Matrix Metalloproteinases ◽  
Inflammatory Cytokines ◽  
Activator Protein 1 ◽  
Activator Protein ◽  
And Cartilage ◽  
Pro Inflammatory Cytokines

We have investigated proteinases that degrade cartilage collagen. We show that pro-inflammatory cytokines act synergistically with oncastatin M to promote cartilage collagen resorption by the up-regulation and activation of matrix metalloproteinases (MMPs). The precise mechanisms are not known, but involve the up-regulation of c-fos, which binds to MMP promoters at a proximal activator protein-1 (AP-1) site. This markedly up-regulates transcription and leads to higher levels of active MMP proteins.

Cleft Lip Rhinoplasty: The Role of Bone and Cartilage Grafts

1989 ◽  
Vol 16 (1) ◽  
pp. 177-186 ◽  
Author(s):  
Fernando Ortiz Monasterio ◽  
Ernesto J. Ruas
Keyword(s):  
Cleft Lip ◽  
Cartilage Grafts ◽  
And Cartilage

Regeneration of bone tissue under implantation of sapphire with titanium coating

2014 ◽  
Vol 0 (3) ◽  
pp. 24 ◽  
Author(s):  
Volodymyr Filipenko ◽  
Inna Batura ◽  
Anatoliy Andreyev ◽  
Оleksey Marushchak
Keyword(s):  
Bone Tissue ◽  
Titanium Coating ◽  
Regeneration Of Bone Tissue ◽  
Regeneration Of Bone

Vitamin D Effects on Guided Bone Regeneration and Osseointegration of Dental Implants (Literature Review)

2020 ◽  
Vol 75 (5) ◽  
pp. 552-560
Author(s):  
Sergey Yu. Ivanov ◽  
Svetlana Yu. Kalinchenko ◽  
Nidjat A. Guseynov ◽  
Aleksander A. Muraev ◽  
Aigul Т. Safi ◽  
...  
Keyword(s):  
Vitamin D ◽  
Bone Tissue ◽  
Dental Implants ◽  
Scientific Data ◽  
Reparative Regeneration ◽  
Jaw Bone ◽  
Dental Implantation ◽  
Oral Reconstruction ◽  
Phosphate Exchange ◽  
Regeneration Of Bone

Background.Due to the prevalence of Vitamin D deficiency as well as the frequency of reconstructive surgical interventions followed by dental implantation, the issue arises concerning the effect of Vitamin D on reparative regeneration of bone and osseointegration of dental implants.The purpose using literature data we are conducting an impact assessment of vitamin D on reparative regeneration of bone tissue, in particular, after oral reconstruction surgeries and dental implantation.Methods.Retrieval, systematization and analysis of scientific data on application of vitamin D supplementation and its effect on reparative regeneration of jaw bone tissue.The conclusions.For the most part, the positive effect exerted on reparative regeneration of jaw bone tissue and osseointegration of dental implants is due to the role of vitamin D in physiological processes evolving in bone tissue, namely maintenance of calcium and phosphate exchange through intestinal absorption and TNF, RANKL (Receptor activator of nuclear factor kappa-B ligand) and consequently differentiation of precursors to osteoclasts into osteoclasts through VDR stimulation (VitaminD Receptor) receptors for further osteogenesis. Also, according to literature data, FGF23 (Fibroblast Growth Factor) protein is a marker of osteoblasts differentiation into osteocytes, it is also known that FGF23 and 1,25(ОН)2D3 are genetically related. FGF23 is the main regulator of both phosphate exchange in bones and metabolism of vitamin D and its metabolites. Besides, indirect anti-inflammatory effect has been observed thanks to inhibition of pro-inflammatory cytokine secretion. Taking into account the abovementioned data, of particular relevance is the definition of serum concentration 25(ОН)D and development of schemes of vitamin D level pre-surgery correction in patients, who have to undergo oral reconstruction surgeries and dental implantation. Mass spectrometry is a promising diagnostic method for determining the level of vitamin D in a body, as it allows to identify the actual amount of vitamin D free from admixture of other steroid hormones. The introduction of this method into clinical practice will allow to monitor the level of vitamin D in patients, receiving reconstructive and rehabilitative treatment.

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