Therapeutic Ratio of Reirradiation with Cytotoxic Drugs and Other Response-Modifying Agents

2016 ◽  
pp. 47-73
Author(s):  
Carsten Nieder ◽  
Avraham Eisbruch
Keyword(s):  
Cytotoxic Drugs ◽  
Therapeutic Ratio

Therapeutic Ratio of Reirradiation with Cytotoxic Drugs and Other Response-Modifying Agents

2010 ◽  
pp. 37-57
Author(s):  
Carsten Nieder ◽  
Avraham Eisbruch
Keyword(s):  
Cytotoxic Drugs ◽  
Therapeutic Ratio

NOXA as Target for the Combination Therapy of Betulinic Acid and Conventional Cytotoxic Drugs

2010 ◽  
Vol 223 (01) ◽  
Author(s):  
I Jeremias ◽  
H Ehrhardt ◽  
I Höfig ◽  
N Terziyska ◽  
P Obexer
Keyword(s):  
Combination Therapy ◽  
Betulinic Acid ◽  
Cytotoxic Drugs

Two drug combinations vs combinations of 3 or more cytotoxic drugs for metastatic breast cancer

2009 ◽  
Author(s):  
Davina Ghersi ◽  
John Simes ◽  
I Craig Henderson ◽  
Russell Basser ◽  
Christine Brunswick ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Metastatic Breast ◽  
Drug Combinations ◽  
Cytotoxic Drugs

scholarly journals The Blockade of Tumoral IL1β-Mediated Signaling in Normal Colonic Fibroblasts Sensitizes Tumor Cells to Chemotherapy and Prevents Inflammatory CAF Activation

2021 ◽  
Vol 22 (9) ◽  
pp. 4960
Author(s):  
Natalia Guillén Díaz-Maroto ◽  
Gemma Garcia-Vicién ◽  
Giovanna Polcaro ◽  
María Bañuls ◽  
Nerea Albert ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Tumor Cells ◽  
Cell Types ◽  
Colorectal Tumor ◽  
Cytotoxic Drugs ◽  
Differential Sensitivity ◽  
Paracrine Signaling ◽  
Inflammatory Phenotype ◽  
Heterotypic Interactions ◽  
Carcinoma Associated Fibroblasts

Heterotypic interactions between newly transformed cells and normal surrounding cells define tumor’s fate in incipient carcinomas. Once homeostasis has been lost, normal resident fibroblasts become carcinoma-associated fibroblasts, conferring protumorogenic properties on these normal cells. Here we describe the IL1β-mediated interplay between cancer cells and normal colonic myofibroblasts (NCFs), which bestows differential sensitivity to cytotoxic drugs on tumor cells. We used NCFs, their conditioned media (CM), and cocultures with tumor cells to characterize the IL1β-mediated crosstalk between both cell types. We silenced IL1β in tumor cells to demonstrate that such cells do not exert an influence on NCFs inflammatory phenotype. Our results shows that IL1β is overexpressed in cocultured tumor cells. IL1β enables paracrine signaling in myofibroblasts, converting them into inflammatory-CAFs (iCAF). IL1β-stimulated-NCF-CM induces migration and differential sensitivity to oxaliplatin in colorectal tumor cells. Such chemoprotective effect has not been evidenced for TGFβ1-driven NCFs. IL1β induces the loss of a myofibroblastic phenotype in NCFs and acquisition of iCAF traits. In conclusion, IL1β-secreted by cancer cells modify surrounding normal fibroblasts to confer protumorogenic features on them, particularly tolerance to cytotoxic drugs. The use of IL1β-blocking agents might help to avoid the iCAF traits acquisition and consequently to counteract the protumorogenic actions these cells.

scholarly journals Physical Resilience as a Determinant of Healthspan and Lifespan in Mice

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 829-829
Author(s):  
Nathan LeBrasseur
Keyword(s):  
Middle Ages ◽  
Interest Group ◽  
Later Life ◽  
Cytotoxic Drugs ◽  
Geriatric Syndromes ◽  
Age Related ◽  
Fundamental Biology ◽  
Dynamic Measures ◽  
Biology Of Aging ◽  
Insight Into

Abstract Dynamic measures of physical resilience—the ability to resist and recover from a challenge—may be informative of biological age far prior to overt manifestations such as age-related diseases and geriatric syndromes (i.e., frailty). If true, physical resilience at younger or middle ages may be predictive of future healthspan and lifespan, and provide a unique paradigm in which interventions targeting the fundamental biology of aging can be tested. This seminar will discuss research on the development of clinically-relevant measures of physical resilience in mice, including anesthesia, surgery, and cytotoxic drugs. It will further highlight how these measures compare between young, middle-aged, and older mice, and how mid-life resilience relates to later-life healthspan. Finally, it will provide insight into whether interventions targeting the biology of aging can modify physical resilience in mice. Part of a symposium sponsored by Epidemiology of Aging Interest Group.

scholarly journals NP-017 Risk assessment of occupational exposure to cytotoxic drugs in an outpatient hospital pharmacy

2021 ◽  
Author(s):  
J Pereira ◽  
R Mateus ◽  
S Pires ◽  
S Sernache ◽  
H Gonçalves ◽  
...  
Keyword(s):  
Risk Assessment ◽  
Occupational Exposure ◽  
Hospital Pharmacy ◽  
Cytotoxic Drugs ◽  
Outpatient Hospital

Cooperative Antitumor Effect of Mixed Backbone Oligonucleotides Targeting Protein Kinase A in Combination with Cytotoxic Drugs or Biologic Agents

1998 ◽  
Vol 8 (2) ◽  
pp. 141-145 ◽  
Author(s):  
GIAMPAOLO TORTORA ◽  
ROSA CAPUTO ◽  
VINCENZO DAMIANO ◽  
ROBERTO BIANCO ◽  
STEFANO PEPE ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Protein Kinase A ◽  
Antitumor Effect ◽  
Biologic Agents ◽  
Cytotoxic Drugs ◽  
Kinase A

Interactions between oestrogen, progestogen and cytotoxic drugs in human breast cancer cells in culture

1987 ◽  
Vol 28 ◽  
pp. 158
Author(s):  
N. Shaikh ◽  
JM. McNeill ◽  
K. Patel ◽  
M. Ghilchik ◽  
H. Braunsberg
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Cytotoxic Drugs ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Cells In Culture

Decrease in aspirin-induced gastric mucosal damage in rats by oral administration of the cytotoxic drugs melphalan and methotrexate

1980 ◽  
Vol 32 (1) ◽  
pp. 544-546 ◽  
Author(s):  
D. A. BERSTOCK ◽  
G. J. FRANK ◽  
I. F. STAMFORD ◽  
A. BENNETT
Keyword(s):  
Oral Administration ◽  
Mucosal Damage ◽  
Cytotoxic Drugs ◽  
Gastric Mucosal Damage
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