Microvascular Dynamics in the Nailfolds of Scleroderma Patients Studied Using Na-Fluorescein dye

Author(s):  
Philip D. Allen ◽  
Chris J. Taylor ◽  
Ariane L. Herrick ◽  
Marina Anderson ◽  
Tonia Moore
Keyword(s):  

2020 ◽  
Vol 5 (1) ◽  
pp. e000542
Author(s):  
Nabil Issa ◽  
Whitney E Liddy ◽  
Sandeep Samant ◽  
David B Conley ◽  
Robert C Kern ◽  
...  

BackgroundCricothyrotomy is associated with significant aerosolization that increases the potential risk of infection among healthcare providers. It is important to identify simple yet effective methods to suppress aerosolization and improve the safety of healthcare providers.Methods5 ear, nose and throat and general surgeons used a locally developed hybrid cricothyrotomy simulator with a porcine trachea to test three draping methods to suppress aerosolization during the procedure: an X-ray cassette drape, dry operating room (OR) towels and wet OR towels. The three methods were judged based on three categories: effectiveness of suppression, availability in all healthcare systems and ease of handling.ResultsAll five surgeons performed the procedure independently using each of the three suppression methods. The wet OR towel drape was found to be an effective method to suppress aerosolization, and it did not hinder the surgeons from performing the procedure accurately. This finding was confirmed by using an atomized fluorescein dye injection into the porcine trachea, representing aerosolized material while performing the procedure.ConclusionsWe present a novel intervention using wet towels to suppress aerosolization during cricothyrotomy. Wet towels are cheap and readily available within any healthcare setting regardless of the financial resources available.



2021 ◽  
Vol 11 (4) ◽  
pp. 1914
Author(s):  
Pingping Han ◽  
Honghui Li ◽  
Laurence J. Walsh ◽  
Sašo Ivanovski

Dental aerosol-generating procedures produce a large amount of splatters and aerosols that create a major concern for airborne disease transmission, such as COVID-19. This study established a method to visualise splatter and aerosol contamination by common dental instrumentation, namely ultrasonic scaling, air-water spray, high-speed and low-speed handpieces. Mock dental procedures were performed on a mannequin model, containing teeth in a typodont and a phantom head, using irrigation water containing fluorescein dye as a tracer. Filter papers were placed in 10 different locations to collect splatters and aerosols, at distances ranging from 20 to 120 cm from the source. All four types of dental equipment produced contamination from splatters and aerosols. At 120 cm away from the source, the high-speed handpiece generated the greatest amount and size (656 ± 551 μm) of splatter particles, while the triplex syringe generated the largest amount of aerosols (particle size: 1.73 ± 2.23 μm). Of note, the low-speed handpiece produced the least amount and size (260 ± 142 μm) of splatter particles and the least amount of aerosols (particle size: 4.47 ± 5.92 μm) at 120 cm. All four dental AGPs produce contamination from droplets and aerosols, with different patterns of distribution. This simple model provides a method to test various preventive strategies to reduce risks from splatter and aerosols.



Author(s):  
Dvir Poplinger ◽  
Andrii Bazylevich ◽  
Maksym Bokan ◽  
Gary Gellerman ◽  
Leonid Patsenker


Author(s):  
Bahador Farshchian ◽  
Junseo Choi ◽  
Sunggook Park

This paper presents the fabrication of a 3D microchannel whose sidewalls and bottom surface are patterned with ratchets using a modified 3D molding process. In the modified 3D molding process the surface of poly(methyl methacrylate) (PMMA) is first patterned using a brass mold having ratchet structures. Then PDMS prepolymer was spin coated over the surface of micropatterned PMMA and cured followed by the primary molding using a brass mold having a T-conjunction protrusion. After primary molding demolding was done by first demolding the brass mold and then peeling off PDMS stamp from PMMA substrate. By setting a 45° angle between direction of ratchets patterned on the surface of PMMA and the brass mold protrusion prior to primary molding 45° slanted ratchets were formed on the sidewall and bottom surface of microchannel using the modified 3D molding. The scanning electron microscope (SEM) micrographs show a successful integration of micropatterns inside the microchannel. Holes were drilled in the inlet and outlet area of the 3D channel before bonding. A solvent bonding technique was used for bonding of 3D channel to a plain cover plate. After bonding capillary tubes were inserted into the holes and glued to the chip using an epoxy glue. For characterization of mixing fluorescence intensity was quantified in the 3D microchannel as deionized water and fluorescein dye injected from different inlets of 3D micromixer were mixed along the 3D microchannel and mixing efficiency was calculated. The results were compared with the data obtained for similar microdevice whose surfaces were not patterned. The results demonstrate at a specific flow rate a faster mixing occurs in a microdevice whose sidewall and bottom surface are patterned with slanted 45° ratchets.



2015 ◽  
Vol 31 (4) ◽  
pp. 296-299 ◽  
Author(s):  
Mohsen Bahmani Kashkouli ◽  
Hoora Mirzajani ◽  
Mansooreh Jamshidian-Tehrani ◽  
Sahab Shahrzad ◽  
Mostafa Soltan Sanjari
Keyword(s):  


1999 ◽  
Vol 25 (11) ◽  
pp. 1423 ◽  
Author(s):  
V E. Gotzaridis ◽  
H W. Ayliffe
Keyword(s):  


2021 ◽  
Vol 32 (1) ◽  
pp. 015003
Author(s):  
Sang-Woo Seo ◽  
Youngsik Song ◽  
Hojjat Rostami Azmand

Abstract Controlled photothermal actuation of liquid release is presented using periodically arrayed hydrogel columns in a macroporous silicon membrane. Thermo-responsive hydrogel is mixed with Gold (Au) nanorods, and surface plasmon-induced local heating by near-infrared (NIR) light is utilized as an actuation method. We adopted theoretical modeling, which treats the hydrogel as a poro-viscoelastic medium to understand the mechanical and liquid transport properties of the hydrogel. To demonstrate the feasibility of the liquid release control using NIR light, we first characterized the temperature response of Au nanorod embedded hydrogel in the silicon membrane using its optical transmission behavior to confirm the successful device fabrication. Next, the liquid release characteristics from the structure were studied using fluorescent imaging of fluorescein dye solution while pulsed NIR light was illuminated on the structure. We successfully demonstrate that the liquid release can be controlled using remote NIR illumination from the presented structure. Considering the periodically arrayed configuration with high spatial resolution, this will have a potential prospect for optically-addressable chemical release systems, which benefit retina prosthesis interfaces.



2013 ◽  
Vol 48 (2) ◽  
pp. 99-103 ◽  
Author(s):  
Cheol Kim ◽  
Min Joung Lee ◽  
Sang In Khwarg
Keyword(s):  


2019 ◽  
Vol 31 (1) ◽  
pp. 55-61
Author(s):  
Sida Niu ◽  
Ryan D. Didde ◽  
Jennifer K. Schuchmann ◽  
Dani Zoorob


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