scholarly journals Analysis Protocol for Dynamic Contrast Enhanced (DCE) MRI of Renal Perfusion and Filtration

2021 ◽  
pp. 637-653
Author(s):  
Frank G. Zöllner ◽  
Walter Dastrù ◽  
Pietro Irrera ◽  
Dario Livio Longo ◽  
Kevin M. Bennett ◽  
...  
Keyword(s):  
Renal Perfusion ◽  
The European Union ◽  
Dce Mri ◽  
Dynamic Contrast Enhanced ◽  
Model Free ◽  
Contrast Enhanced ◽  
Renal Mri ◽  
The Cost ◽  
Concentration Mapping ◽  
Analysis Protocol

AbstractHere we present an analysis protocol for dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) data of the kidneys. It covers comprehensive steps to facilitate signal to contrast agent concentration mapping via T1 mapping and the calculation of renal perfusion and filtration parametric maps using model-free approaches, model free analysis using deconvolution, the Toft’s model and a Bayesian approach.This chapter is based upon work from the COST Action PARENCHIMA, a community-driven network funded by the European Cooperation in Science and Technology (COST) program of the European Union, which aims to improve the reproducibility and standardization of renal MRI biomarkers. This analysis protocol chapter is complemented by two separate chapters describing the basic concept and experimental procedure.

scholarly journals Dynamic Contrast Enhanced (DCE) MRI-Derived Renal Perfusion and Filtration: Experimental Protocol

2021 ◽  
pp. 429-441
Author(s):  
Pietro Irrera ◽  
Lorena Consolino ◽  
Walter Dastrù ◽  
Michael Pedersen ◽  
Frank G. Zöllner ◽  
...  
Keyword(s):  
Renal Perfusion ◽  
The European Union ◽  
Experimental Protocol ◽  
Small Molecular Weight ◽  
Dce Mri ◽  
Dynamic Contrast Enhanced ◽  
Contrast Enhanced ◽  
Renal Mri ◽  
The Cost

AbstractDynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) can provide a noninvasive way for assessing renal functional information following the administration of a small molecular weight gadolinium-based contrast agent. This method may be useful for investigating renal perfusion and glomerular filtration rates of rodents in vivo under various experimental (patho)physiological conditions. Here we describe a step-by-step protocol for DCE-MRI studies in small animals providing practical notes on acquisition parameters, sequences, T1 mapping approaches and procedures.This chapters is based upon work from the COST Action PARENCHIMA, a community-driven network funded by the European Cooperation in Science and Technology (COST) program of the European Union, which aims to improve the reproducibility and standardization of renal MRI biomarkers. This experimental protocol chapter is complemented by two separate chapters describing the basic concept and data analysis.

scholarly journals Dynamic Contrast Enhancement (DCE) MRI–Derived Renal Perfusion and Filtration: Basic Concepts

2021 ◽  
pp. 205-227
Author(s):  
Michael Pedersen ◽  
Pietro Irrera ◽  
Walter Dastrù ◽  
Frank G. Zöllner ◽  
Kevin M. Bennett ◽  
...  
Keyword(s):  
Glomerular Filtration Rate ◽  
Contrast Agents ◽  
Glomerular Filtration ◽  
Filtration Rate ◽  
Renal Perfusion ◽  
The European Union ◽  
Dce Mri ◽  
Indirect Measures ◽  
Renal Mri ◽  
The Cost

AbstractDynamic contrast-enhanced (DCE) MRI monitors the transit of contrast agents, typically gadolinium chelates, through the intrarenal regions, the renal cortex, the medulla, and the collecting system. In this way, DCE-MRI reveals the renal uptake and excretion of the contrast agent. An optimal DCE-MRI acquisition protocol involves finding a good compromise between whole-kidney coverage (i.e., 3D imaging), spatial and temporal resolution, and contrast resolution. By analyzing the enhancement of the renal tissues as a function of time, one can determine indirect measures of clinically important single-kidney parameters as the renal blood flow, glomerular filtration rate, and intrarenal blood volumes. Gadolinium-containing contrast agents may be nephrotoxic in patients suffering from severe renal dysfunction, but otherwise DCE-MRI is clearly useful for diagnosis of renal functions and for assessing treatment response and posttransplant rejection.Here we introduce the concept of renal DCE-MRI, describe the existing methods, and provide an overview of preclinical DCE-MRI applications to illustrate the utility of this technique to measure renal perfusion and glomerular filtration rate in animal models.This publication is based upon work from the COST Action PARENCHIMA, a community-driven network funded by the European Cooperation in Science and Technology (COST) program of the European Union, which aims to improve the reproducibility and standardization of renal MRI biomarkers. This introduction is complemented by two separate publications describing the experimental procedure and data analysis.

scholarly journals Quantitative Assessment of Renal Perfusion and Oxygenation by Invasive Probes: Basic Concepts

2021 ◽  
pp. 89-107
Author(s):  
Kathleen Cantow ◽  
Roger G. Evans ◽  
Dirk Grosenick ◽  
Thomas Gladytz ◽  
Thoralf Niendorf ◽  
...  
Keyword(s):  
Kidney Injury ◽  
Tissue Perfusion ◽  
Renal Perfusion ◽  
Renal Tissue ◽  
Acute Injury ◽  
The European Union ◽  
Advantages And Disadvantages ◽  
Tissue Hypoperfusion ◽  
Renal Mri ◽  
The Cost

AbstractRenal tissue hypoperfusion and hypoxia are early key elements in the pathophysiology of acute kidney injury of various origins, and may also promote progression from acute injury to chronic kidney disease. Here we describe basic principles of methodology to quantify renal hemodynamics and tissue oxygenation by means of invasive probes in experimental animals. Advantages and disadvantages of the various methods are discussed in the context of the heterogeneity of renal tissue perfusion and oxygenation.This chapter is based upon work from the COST Action PARENCHIMA, a community-driven network funded by the European Cooperation in Science and Technology (COST) program of the European Union, which aims to improve the reproducibility and standardization of renal MRI biomarkers. This introduction chapter is complemented by a separate chapter describing the experimental procedure and data analysis.

scholarly journals Noninvasive Renal Perfusion Measurement Using Arterial Spin Labeling (ASL) MRI: Basic Concept

2021 ◽  
pp. 229-239
Author(s):  
Min-Chi Ku ◽  
María A. Fernández-Seara ◽  
Frank Kober ◽  
Thoralf Niendorf
Keyword(s):  
Basic Concept ◽  
Arterial Spin Labeling ◽  
Regional Distribution ◽  
Spin Labeling ◽  
Renal Perfusion ◽  
The European Union ◽  
Perfusion Measurement ◽  
Metabolic Products ◽  
Renal Mri ◽  
The Cost

AbstractThe kidney is a complex organ involved in the excretion of metabolic products as well as the regulation of body fluids, osmolarity, and homeostatic status. These functions are influenced in large part by alterations in the regional distribution of blood flow between the renal cortex and medulla. Renal perfusion is therefore a key determinant of glomerular filtration. Therefore the quantification of regional renal perfusion could provide important insights into renal function and renal (patho)physiology. Arterial spin labeling (ASL) based perfusion MRI techniques, can offer a noninvasive and reproducible way of measuring renal perfusion in animal models. This chapter addresses the basic concept of ASL-MRI.This chapter is based upon work from the COST Action PARENCHIMA, a community-driven network funded by the European Cooperation in Science and Technology (COST) program of the European Union, which aims to improve the reproducibility and standardization of renal MRI biomarkers. This introduction chapter is complemented by two separate chapters describing the experimental procedure and data analysis.

scholarly journals Analysis Protocols for MRI Mapping of Renal T1

2021 ◽  
pp. 577-590
Author(s):  
Philippe Garteiser ◽  
Gwenaël Pagé ◽  
Sabrina Doblas ◽  
Octavia Bane ◽  
Stefanie Hectors ◽  
...  
Keyword(s):  
Software Requirements ◽  
Small Animals ◽  
The European Union ◽  
Experimental Procedure ◽  
European Cooperation ◽  
Precise Characterization ◽  
Renal Mri ◽  
The Cost ◽  
Analysis Protocol

AbstractThe computation of T1 maps from MR datasets represents an important step toward the precise characterization of kidney disease models in small animals. Here the main strategies to analyze renal T1 mapping datasets derived from small rodents are presented. Suggestions are provided with respect to essential software requirements, and advice is provided as to how dataset completeness and quality may be evaluated. The various fitting models applicable to T1 mapping are presented and discussed. Finally, some methods are proposed for validating the obtained results.This chapter is based upon work from the COST Action PARENCHIMA, a community-driven network funded by the European Cooperation in Science and Technology (COST) program of the European Union, which aims to improve the reproducibility and standardization of renal MRI biomarkers. This analysis protocol chapter is complemented by two separate chapters describing the basic concept and experimental procedure.

scholarly journals Analysis Methods for Hyperpolarized Carbon (13C) MRI of the Kidney

2021 ◽  
pp. 697-710
Author(s):  
Galen D. Reed ◽  
Natalie J. Korn ◽  
Christoffer Laustsen ◽  
Cornelius von Morze
Keyword(s):  
Imaging Modality ◽  
Functional Information ◽  
The European Union ◽  
Experimental Procedure ◽  
European Cooperation ◽  
Renal Mri ◽  
And Function ◽  
The Cost ◽  
Analysis Protocol

AbstractHyperpolarized 13C MR is a novel medical imaging modality with substantially different signal dynamics as compared to conventional 1H MR, thus requiring new methods for processing the data in order to access and quantify the embedded metabolic and functional information. Here we describe step-by-step analysis protocols for functional renal hyperpolarized 13C imaging. These methods are useful for investigating renal blood flow and function as well as metabolic status of rodents in vivo under various experimental physiological conditions.This chapter is based upon work from the COST Action PARENCHIMA, a community-driven network funded by the European Cooperation in Science and Technology (COST) program of the European Union, which aims to improve the reproducibility and standardization of renal MRI biomarkers. This analysis protocol chapter is complemented by two separate chapters describing the basic concept and experimental procedure.

scholarly journals Analysis Protocol for Renal Sodium (23Na) MR Imaging

2021 ◽  
pp. 689-696
Author(s):  
James T. Grist ◽  
Esben Søvsø Szocska Hansen ◽  
Frank G. Zöllner ◽  
Christoffer Laustsen
Keyword(s):  
Mr Imaging ◽  
The European Union ◽  
Simple Task ◽  
European Cooperation ◽  
Concentration Estimation ◽  
Sodium Gradient ◽  
Quadrupolar Relaxation ◽  
Renal Mri ◽  
The Cost ◽  
Analysis Protocol

AbstractThe signal acquired in sodium (23Na) MR imaging is proportional to the concentration of sodium in a voxel, and it is possible to convert between the two using external calibration phantoms. Postprocessing, and subsequent analysis, of sodium renal images is a simple task that can be performed with readily available software. Here we describe the process of conversion between sodium signal and concentration, estimation of the corticomedullary sodium gradient and the procedure used for quadrupolar relaxation analysis.This chapter is based upon work from the COST Action PARENCHIMA, a community-driven network funded by the European Cooperation in Science and Technology (COST) program of the European Union, which aims to improve the reproducibility and standardization of renal MRI biomarkers. This analysis protocol chapter is complemented by two separate chapters describing the basic concept and experimental procedure.

scholarly journals Quantitative Analysis of Renal Perfusion by Arterial Spin Labeling

2021 ◽  
pp. 655-666
Author(s):  
Kai-Hsiang Chuang ◽  
Frank Kober ◽  
Min-Chi Ku
Keyword(s):  
Renal Perfusion ◽  
The European Union ◽  
Nonlinear Fitting ◽  
Multiple Delay ◽  
Delay Times ◽  
Tracer Kinetic ◽  
Arterial Transit Time ◽  
Magnetic Resonance Imaging Mri ◽  
Renal Mri ◽  
The Cost

AbstractThe signal intensity differences measured by an arterial-spin-labelling (ASL) magnetic resonance imaging (MRI) experiment are proportional to the local perfusion, which can be quantified with kinetic modeling. Here we present a step-by-step tutorial for the data post-processing needed to calculate an ASL perfusion map. The process of developing an analysis software is described with the essential program code, which involves nonlinear fitting a tracer kinetic model to the ASL data. Key parameters for the quantification are the arterial transit time (ATT), which is the time the labeled blood takes to flow from the labeling area to the tissue, and the tissue T1. As ATT varies with vasculature, physiology, anesthesia and pathology, it is recommended to measure it using multiple delay times. The tutorial explains how to analyze ASL data with multiple delay times and a T1 map for quantification.This chapter is based upon work from the COST Action PARENCHIMA, a community-driven network funded by the European Cooperation in Science and Technology (COST) program of the European Union, which aims to improve the reproducibility and standardization of renal MRI biomarkers. This analysis protocol chapter is complemented by two separate chapters describing the basic concept and experimental procedure.

scholarly journals MP54-01 DYNAMIC CONTRAST ENHANCED MRI (DCE-MRI) FOR EVALUATION OF THE EFFECTS OF RENO-PROTECTIVE DRUGS ON RENAL PERFUSION AFTER SWL

2016 ◽  
Vol 195 (4S) ◽  
Author(s):  
Ahmed EL-Nahas ◽  
Mohamed Abo EL-Ghar ◽  
Diaa-Eldin Taha ◽  
Mohamed Elsaadany ◽  
Ahmed Elshal ◽  
...  
Keyword(s):  
Renal Perfusion ◽  
Dce Mri ◽  
Dynamic Contrast Enhanced Mri ◽  
Dynamic Contrast Enhanced ◽  
Enhanced Mri ◽  
Contrast Enhanced ◽  
Contrast Enhanced Mri

scholarly journals Perfusion in hand arthritis on dynamic contrast-enhanced computed tomography: a randomized prospective study using MRI as a standard of reference

2020 ◽  
Vol 50 (1) ◽  
pp. 59-68
Author(s):  
Sevtap Tugce Ulas ◽  
Kay Geert Hermann ◽  
Marcus R. Makowski ◽  
Robert Biesen ◽  
Fabian Proft ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Mean Transit Time ◽  
Region Of Interest ◽  
T Test ◽  
Dose Length Product ◽  
Suitable Alternative ◽  
Dce Mri ◽  
Dynamic Contrast Enhanced ◽  
Contrast Enhanced Ct ◽  
Contrast Enhanced

Abstract Objective To evaluate the performance of dynamic contrast-enhanced CT (DCE-CT) in detecting and quantitatively assessing perfusion parameters in patients with arthritis of the hand compared with dynamic contrast-enhanced MRI (DCE-MRI) as a standard of reference. Materials and methods In this IRB-approved randomized prospective single-centre study, 36 consecutive patients with suspected rheumatoid arthritis underwent DCE-CT (320-row, tube voltage 80 kVp, tube current 8.25 mAs) and DCE-MRI (1.5 T) of the hand. Perfusion maps were calculated separately for mean transit time (MTT), time to peak (TTP), relative blood volume (rBV), and relative blood flow (rBF) using four different decomposition techniques. Region of interest (ROI) analysis was performed in metacarpophalangeal joints II–V and in the wrist. Pairs of perfusion parameters in DCE-CT and DCE-MRI were compared using a two-tailed t test for paired samples and interpreted for effect size (Cohen’s d). According to the Rheumatoid Arthritis Magnetic Resonance Imaging Score (RAMRIS) scoring results, differentiation of synovitis-positive and synovitis-negative joints with both modalities was assessed with the independent t test. Results The two modalities yielded similar perfusion parameters. Identified differences had small effects (d 0.01–0.4). DCE-CT additionally differentiates inflamed and noninflamed joints based on rBF and rBV but tends to underestimate these parameters in severe inflammation. The total dose-length product (DLP) was 48 mGy*cm with an estimated effective dose of 0.038 mSv. Conclusion DCE-CT is a promising imaging technique in arthritis. In patients with a contraindication to MRI or when MRI is not available, DCE-CT is a suitable alternative to detect and assess arthritis.

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