An Approach to Study Melanoma Invasion and Crosstalk with Lymphatic Endothelial Cell Spheroids in 3D Using Immunofluorescence

2021 ◽  
pp. 141-154
Author(s):  
Sanni Alve ◽  
Silvia Gramolelli ◽  
Päivi M. Ojala
Keyword(s):  
Endothelial Cell ◽  
Lymphatic Endothelial Cell ◽  
Cell Spheroids ◽  
Melanoma Invasion

scholarly journals Vascular endothelial cell specification in health and disease

Angiogenesis ◽  
2021 ◽  
Author(s):  
Corina Marziano ◽  
Gael Genet ◽  
Karen K. Hirschi
Keyword(s):  
Endothelial Cells ◽  
Endothelial Cell ◽  
Current Knowledge ◽  
Vascular Malformations ◽  
Immune Surveillance ◽  
Vascular Endothelial Cell ◽  
Lymphatic Vessels ◽  
Lymphatic Endothelial Cell ◽  
The Body ◽  
Vascular Networks

AbstractThere are two vascular networks in mammals that coordinately function as the main supply and drainage systems of the body. The blood vasculature carries oxygen, nutrients, circulating cells, and soluble factors to and from every tissue. The lymphatic vasculature maintains interstitial fluid homeostasis, transports hematopoietic cells for immune surveillance, and absorbs fat from the gastrointestinal tract. These vascular systems consist of highly organized networks of specialized vessels including arteries, veins, capillaries, and lymphatic vessels that exhibit different structures and cellular composition enabling distinct functions. All vessels are composed of an inner layer of endothelial cells that are in direct contact with the circulating fluid; therefore, they are the first responders to circulating factors. However, endothelial cells are not homogenous; rather, they are a heterogenous population of specialized cells perfectly designed for the physiological demands of the vessel they constitute. This review provides an overview of the current knowledge of the specification of arterial, venous, capillary, and lymphatic endothelial cell identities during vascular development. We also discuss how the dysregulation of these processes can lead to vascular malformations, and therapeutic approaches that have been developed for their treatment.

Mafba and  Mafbb Differentially Regulate Lymphatic Endothelial Cell Migration in Topographically Distinct Manners

2021 ◽  
Author(s):  
Hannah Arnold ◽  
Virginia Panara ◽  
Beata Filipek-Gorniok ◽  
Renae Skoczylas ◽  
Petter Ranefall ◽  
...  
Keyword(s):  
Cell Migration ◽  
Endothelial Cell ◽  
Lymphatic Endothelial Cell ◽  
Endothelial Cell Migration

scholarly journals Regulation of the lymphatic endothelial cell cycle by the PROX1 homeodomain protein

2011 ◽  
Vol 1813 (1) ◽  
pp. 201-212 ◽  
Author(s):  
Shannon A. Baxter ◽  
David Y. Cheung ◽  
Patricia Bocangel ◽  
Hae K. Kim ◽  
Krista Herbert ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Endothelial Cell ◽  
Lymphatic Endothelial Cell ◽  
Homeodomain Protein

scholarly journals Cryptotanshinone Inhibits Lymphatic Endothelial Cell Tube Formation by Suppressing VEGFR-3/ERK and Small GTPase Pathways

2011 ◽  
Vol 4 (12) ◽  
pp. 2083-2091 ◽  
Author(s):  
Yan Luo ◽  
Wenxing Chen ◽  
Hongyu Zhou ◽  
Lei Liu ◽  
Tao Shen ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Lymphatic Endothelial Cell ◽  
Tube Formation ◽  
Small Gtpase
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