Immortalization and Tumorigenic Transformation of Normal Human Cervical Epithelial Cells Transfected with Human Papillomavirus DNAs

1991 ◽  
pp. 153-161
Author(s):  
Craig D. Woodworth
Keyword(s):  
Human Papillomavirus ◽  
Epithelial Cells ◽  
Tumorigenic Transformation ◽  
Normal Human ◽  
Cervical Epithelial Cells

Polymorphism of TP53 gene and the risk of high human papillomavirus load in cervical epithelial cells

Gene Reports ◽  
2022 ◽  
Vol 26 ◽  
pp. 101456
Author(s):  
Abbas Hadi Albosale ◽  
Olga Andreevna Garbuzova ◽  
Konstantin Alekseevich Kovalenko ◽  
Elena Vladimirovna Mashkina
Keyword(s):  
Human Papillomavirus ◽  
Epithelial Cells ◽  
Tp53 Gene ◽  
Cervical Epithelial Cells

scholarly journals Human herpesvirus 6 infects cervical epithelial cells and transactivates human papillomavirus gene expression.

1994 ◽  
Vol 68 (2) ◽  
pp. 1173-1178 ◽  
Author(s):  
M Chen ◽  
N Popescu ◽  
C Woodworth ◽  
Z Berneman ◽  
M Corbellino ◽  
...  
Keyword(s):  
Gene Expression ◽  
Human Papillomavirus ◽  
Epithelial Cells ◽  
Human Herpesvirus ◽  
Human Herpesvirus 6 ◽  
Cervical Epithelial Cells ◽  
Herpesvirus 6

scholarly journals Analysis of novel human papillomavirus type 16 late mRNAs in differentiated W12 cervical epithelial cells

Virology ◽  
2007 ◽  
Vol 360 (1) ◽  
pp. 172-181 ◽  
Author(s):  
Steven G. Milligan ◽  
Thanaporn Veerapraditsin ◽  
Boolang Ahamet ◽  
Sarah Mole ◽  
Sheila V. Graham
Keyword(s):  
Human Papillomavirus ◽  
Epithelial Cells ◽  
Human Papillomavirus Type 16 ◽  
Cervical Epithelial Cells

scholarly journals Involvement of the Toll-Like Receptor/Nitric Oxide Signaling Pathway in the Pathogenesis of Cervical Cancer Caused by High-Risk Human Papillomavirus Infection

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Jie Li ◽  
Heping Rao ◽  
Chang’e Jin ◽  
Jinrong Liu
Keyword(s):  
Nitric Oxide ◽  
Cervical Cancer ◽  
Human Papillomavirus ◽  
High Risk ◽  
Epithelial Cells ◽  
Signaling Pathway ◽  
Cervical Canal ◽  
Toll Like Receptor ◽  
No Signaling ◽  
Cervical Epithelial Cells

Human papillomavirus (HPV) can activate Toll-like receptor (TLR)/nitric oxide (NO) signaling pathways; however, whether the TLR/NO pathway is involved in cervical cancer caused by high-risk HPV (HR-HPV) remains unclear. In this study, 43 HR-HPV-positive patients with cervical cancer (CC group), 39 HR-HPV-positive patients with a healthy cervix (HR-HPV group), and 33 HR-HPV-negative controls were recruited. NO concentration in cervical canal and expression of inducible NO synthase (iNOS) in cervical tissues were detected. Expressions of key TLR/NO pathway genes (TLR3/4/7/8, NF-κB p65, and iNOS) in cervical epithelial cells were detected by quantitative reverse transcription PCR. Expressions of TLR4, NF-κB p65, and iNOS in CaSki, HeLa, and C33a cells were determined by Western blot. NO concentration in cervical canal of CC group was significantly higher than in other groups (P<0.05). Positive rates of iNOS in cervical tissues were 72.1%, 28.2%, and 3.1% in the CC group, HR-HPV group, and controls, respectively (P<0.05). Levels of TLR3, TLR4, TLR7, TLR8, NF-κB p65, and iNOS in cervical epithelial cells were higher in CC group than in other groups (P<0.05). Both mRNA and protein levels of TLR4, NF-κB p65, and iNOS were higher in HPV-positive HeLa and CaSki cells than in HPV-negative C33a cells (P<0.05). Together, these results suggest that TLR/NO signaling pathway may be involved in pathogenesis of cervical cancer caused by HR-HPV.

Gallic acid induces apoptosis in human cervical epithelial cells containing human papillomavirus type 16 episomes

2015 ◽  
Vol 88 (1) ◽  
pp. 127-134 ◽  
Author(s):  
Lin Shi ◽  
Yanjun Lei ◽  
Ranjana Srivastava ◽  
Weihua Qin ◽  
Jason J. Chen
Keyword(s):  
Human Papillomavirus ◽  
Epithelial Cells ◽  
Gallic Acid ◽  
Human Papillomavirus Type 16 ◽  
Cervical Epithelial Cells

scholarly journals Human papillomavirus type 16 E6 and E 7 proteins alter NF-kB in cultured cervical epithelial cells and inhibition of NF-kB promotes cell growth and immortalization

Virology ◽  
2012 ◽  
Vol 425 (1) ◽  
pp. 53-60 ◽  
Author(s):  
Erik R. Vandermark ◽  
Krysta A. Deluca ◽  
Courtney R. Gardner ◽  
Daniel F. Marker ◽  
Cynthia N. Schreiner ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Cell Growth ◽  
Epithelial Cells ◽  
Human Papillomavirus Type 16 ◽  
Cervical Epithelial Cells
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