The Influence of the Vitamin D and Estrogen Receptor Genotypes on Bone Mineral Density Changes in Teenage Girls Supplemented with Dairy Products

1998 ◽  
pp. 107-116
Author(s):  
Nigel Leslie Gilchrist ◽  
Elizabeth J. Smart ◽  
John G. Turner ◽  
Peter M. George ◽  
Chris M. Frampton
Keyword(s):  
Bone Mineral Density ◽  
Vitamin D ◽  
Estrogen Receptor ◽  
Bone Mineral ◽  
Dairy Products ◽  
Mineral Density ◽  
Teenage Girls

Relation of the estrogen receptor and vitamin D receptor polymorphisms with bone mineral density in postmenopausal Mexican-mestizo women

Gene ◽  
2014 ◽  
Vol 537 (1) ◽  
pp. 10-14 ◽  
Author(s):  
David Rojano-Mejía ◽  
Ramón Mauricio Coral-Vázquez ◽  
Agustín Coronel ◽  
Leticia Cortes-Espinosa ◽  
María del Carmen Aguirre-García ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Vitamin D ◽  
Estrogen Receptor ◽  
Bone Mineral ◽  
Vitamin D Receptor ◽  
Mineral Density ◽  
Mexican Mestizo

Effects of vitamin D and estrogen receptor polymorphisms on bone mineral density in adolescents with anorexia nervosa

2019 ◽  
Vol 32 (12) ◽  
pp. 1377-1384
Author(s):  
Işıl İnan-Erdoğan ◽  
Sinem Akgül ◽  
Kübra Işgın-Atıcı ◽  
Tuğba Tuğrul-Yücel ◽  
Koray Boduroğlu ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Vitamin D ◽  
Estrogen Receptor ◽  
Anorexia Nervosa ◽  
Bone Mineral ◽  
Mineral Density ◽  
Vdr Gene ◽  
Positive Effects ◽  
Z Scores ◽  
Positive Effect

Abstract Background Anorexia nervosa (AN) is a serious eating disorder that is associated with decreased bone mineral density (BMD) and greater lifetime risk for fractures. The aim of this study was to determine the correlation between BMD and genetic polymorphisms in AN. Methods This case-control study analyzed vitamin D receptor (VDR) (VDRBsml, VDRFokl) and estrogen receptor (ESR) (ESR1Xbal, ESR1Pvull) polymorphisms in 45 adolescents diagnosed with AN and 46 age-matched healthy controls. BMD values of the AN group were classified as low or normal, and polymorphisms were compared between cases and controls. The effects of body mass index (BMI), duration of disease and amenorrhea on BMD were also evaluated. Results In girls with AN, a positive effect of the bb genotype of VDRBsmI polymorphism on femur Z-scores (p = 0.103) and of the Ff genotype of VDRFokI polymorphism on vertebra Z-scores (p = 0.097) was observed. In boys with AN, a positive effect of the Ff genotype of VDRFokI polymorphism on vertebra BMD (g/cm2) was detected (p = 0.061). No association was detected between ESR polymorphisms. An inverse relationship was observed between BMD and duration of illness and amenorrhea. A direct relationship was detected between BMD and BMI. Conclusions Specific VDR gene polymorphism genotypes may have positive effects on BMD in patients with AN. Additionally, the lack of association between ESR gene polymorphisms on BMD could be attributed to the low estrogen status of the patient.

scholarly journals Bone mineral density is associated with vitamin D related rs6013897 and estrogen receptor polymorphism rs4870044: The Tromsø study

PLoS ONE ◽  
2017 ◽  
Vol 12 (3) ◽  
pp. e0173045 ◽  
Author(s):  
Ieva Martinaityte ◽  
Rolf Jorde ◽  
Nina Emaus ◽  
Anne Elise Eggen ◽  
Ragnar Martin Joakimsen ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Vitamin D ◽  
Estrogen Receptor ◽  
Bone Mineral ◽  
Mineral Density ◽  
Receptor Polymorphism

scholarly journals Skeletal site-dependent response of bone mineral density and quantitative ultrasound parameters following a 12-month dietary intervention using dairy products fortified with calcium and vitamin D: the Postmenopausal Health Study

2006 ◽  
Vol 96 (6) ◽  
pp. 1140-1148 ◽  
Author(s):  
George Moschonis ◽  
Yannis Manios
Keyword(s):  
Bone Mineral Density ◽  
Vitamin D ◽  
Postmenopausal Women ◽  
Bone Mineral ◽  
Quantitative Ultrasound ◽  
Dairy Products ◽  
The Other ◽  
Mineral Density ◽  
Skeletal Site ◽  
Total Body

The aim of the current study was to examine whether calcium supplementation could prevent bone loss in postmenopausal women or more favourable outcomes could be obtained via the consumption of dairy products fortified with calcium and vitamin D3. For this purpose changes in bone mineral density (BMD) at different skeletal sites, assessed by dual-energy X-ray absorptiometry, as well as in quantitative ultrasound (QUS) parameters of the calcaneus over 12 months were estimated. A population of 101 postmenopausal women (55–65 years old) was randomized into a dairy group (DG: n 39), receiving approximately 1200 mg calcium/d and 7·5 μg vitamin D3/d through fortified dairy products; a calcium-supplemented group (CaG: n 26) provided with a calcium supplement of 600 mg/d; and a control group (CG: n 36). Over the intervention period the DG was found to have more favourable changes in pelvis (P = 0·040), total spine (P < 0·001) and total body BMD (P < 0·001) than the other groups. A significant increase was also observed for DG in lumbar spine BMD (2·0 %; 95 % CI 0·5, 3·5) although it did not differentiate significantly compared to the other groups. No significant differences were observed with respect to the changes in QUS parameters. The current study revealed that recommended intakes of vitamin D3 and calcium via fortified dairy products for 12 months can induce favourable changes in pelvis, total spine and total body BMD in postmenopausal women but not in QUS parameters. No such favourable changes were observed via supplementation of calcium alone.

scholarly journals The effects of a 30-month dietary intervention on bone mineral density: The Postmenopausal Health Study

2010 ◽  
Vol 104 (1) ◽  
pp. 100-107 ◽  
Author(s):  
George Moschonis ◽  
Ioanna Katsaroli ◽  
George P. Lyritis ◽  
Yannis Manios
Keyword(s):  
Bone Mineral Density ◽  
Vitamin D ◽  
Postmenopausal Women ◽  
Bone Mineral ◽  
Dairy Products ◽  
Dietary Intervention ◽  
Control Group ◽  
Mineral Density ◽  
Nutrition Counselling ◽  
Total Body

Low dietary Ca intake and vitamin D insufficiency have been implicated as part of the aetiology leading to osteoporosis. The aim of the present study was to examine the effects of a 30-month dietary intervention that combined supplementation of dairy products fortified with Ca and vitamin D3 and lifestyle and nutrition counselling sessions on bone mineral density (BMD) of postmenopausal women. Sixty-six postmenopausal women (aged 55–65 years) were randomised into a dietary group (DG; n 35), receiving daily and for the first 12 months 1200 mg Ca and 7·5 μg vitamin D3, while for the next 18 months of intervention 1200 mg Ca and 22·5 μg vitamin D3 through fortified dairy products, and a control group (CG; n 31) receiving neither counselling nor dairy products. The DG was found to have more favourable changes in arms (P < 0·001), total spine (P = 0·001) and total body BMD (P < 0·001) compared with the CG. Furthermore, a significant increase was observed for the DG in lumbar spine BMD (0·056; 95 % CI 0·009, 0·103), which was not found to differentiate significantly compared with the change observed in the CG (P = 0·075). In conclusion, the present study showed that intakes of vitamin D of about 22·5 μg/d and of Ca close to the recommended level of 1200 mg from fortified dairy foods for 30 months, with compliance ensured by lifestyle and nutrition counselling sessions, can induce favourable changes in arms, total spine and total body BMD of postmenopausal women.

Evaluation of the effects of vitamin D receptor and estrogen receptor 1 gene polymorphisms on bone mineral density in postmenopausal women

2010 ◽  
Vol 29 (11) ◽  
pp. 1285-1293 ◽  
Author(s):  
Mine Durusu Tanriover ◽  
Gamze Bora Tatar ◽  
Tenzile Deniz Uluturk ◽  
Didem Dayangac Erden ◽  
Altug Tanriover ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Vitamin D ◽  
Estrogen Receptor ◽  
Postmenopausal Women ◽  
Bone Mineral ◽  
Vitamin D Receptor ◽  
Gene Polymorphisms ◽  
Mineral Density ◽  
Estrogen Receptor 1
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