Effects of Aging and Hypertension on Cerebral Blood Flow and Autoregulation in Normal Subjects and CVD Patients

1985 ◽  
pp. 185-194
Author(s):  
Yukito Shinohara
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Normal Subjects ◽  
Effects Of Aging

scholarly journals Comparison of the Effects of Intravenous Papaverine Hydrochloride and Oral Pavabid HP Capsulets on Regional Cerebral Blood Flow in Normal Individuals

1983 ◽  
Vol 3 (4) ◽  
pp. 442-447 ◽  
Author(s):  
Lawrence C. McHenry ◽  
David A. Stump ◽  
George Howard ◽  
Thomas T. Novack ◽  
Don H. Bivins ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Regional Cerebral Blood Flow ◽  
Normal Subjects ◽  
Normal Male ◽  
Regional Cerebral Blood ◽  
Normal Individuals ◽  
Left And Right ◽  
Male Subjects ◽  
Papaverine Hydrochloride

A single-blind study was conducted in 13 right-handed normal male subjects to compare the effects of oral and i.v. papaverine on regional cerebral blood flow (rCBF). Six xenon-133 inhalation rCBF measurements were performed on each subject; three tests—baseline, placebo, and drug evaluations—were carried out on each of two separate days. The oral and i.v. drugs were randomized for first-day administration. rCBF, measured as flow gray (FG), increased significantly (p ≤ 0.001) from baseline with both drug forms. Increases of 10.53% and 13.94% (left and right hemispheres, respectively) were demonstrated 90 min after a single 600-mg dose of oral papaverine. Increases of 5.09% and 8.69%, respectively, were recorded immediately after a single 100-mg dose of i. v. papaverine. FG also increased significantly (p ≤ 0.001) for both drug forms when compared to that of placebo. Placebo produced only a slight increase (not significant) with both the oral and i.v. groups. The data show that both oral and i.v. papaverine are equally effective in increasing rCBF in normal subjects.

Effects of Defibrination on Hemorheology, Cerebral Blood Flow Velocity, and CO 2 Reactivity During Hypocapnia in Normal Subjects

Stroke ◽  
1996 ◽  
Vol 27 (8) ◽  
pp. 1328-1332 ◽  
Author(s):  
Yoshinari Izumi ◽  
Yoshiyasu Tsuda ◽  
Shin-Ichiro Ichihara ◽  
Tsutomu Takahashi ◽  
Hirohide Matsuo
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Flow Velocity ◽  
Blood Flow Velocity ◽  
Cerebral Blood Flow Velocity ◽  
Normal Subjects

Regional cerebral blood flow asymmetries in a group of 189 normal subjects at rest

1991 ◽  
Vol 4 (1) ◽  
pp. 57-63 ◽  
Author(s):  
Guido Rodriguez ◽  
Richard Coppola ◽  
Fabrizio De Carli ◽  
Stefano Francione ◽  
Stefano Marenco ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Regional Cerebral Blood Flow ◽  
Normal Subjects ◽  
Regional Cerebral Blood

scholarly journals Cerebral Blood Flow Measurements by Magnetic Resonance Imaging Bolus Tracking: Comparison with [15O]H2O Positron Emission Tomography in Humans

1998 ◽  
Vol 18 (9) ◽  
pp. 935-940 ◽  
Author(s):  
Leif Østergaard ◽  
Peter Johannsen ◽  
Peter Høst-Poulsen ◽  
Peter Vestergaard-Poulsen ◽  
Helle Asboe ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Magnetic Resonance ◽  
Normal Subjects ◽  
Emission Tomography ◽  
Flow Measurements ◽  
Bolus Tracking ◽  
Positron Emission ◽  
Blood Flow Measurements

In six young, healthy volunteers, a novel method to determine cerebral blood flow (CBF) using magnetic resonance (MR) bolus tracking was compared with [15O]H2O positron emission tomography (PET). The method yielded parametric CBF images with tissue contrast in good agreement with parametric PET CBF images. Introducing a common conversion factor, MR CBF values could be converted into absolute flow rates, allowing comparison of CBF values among normal subjects.

scholarly journals Cerebral Blood Flow Studied by Xenon-133 Inhalation Technique in Parkinsonism: Loss of Hyperfrontal Pattern

1983 ◽  
Vol 3 (1) ◽  
pp. 33-37 ◽  
Author(s):  
A. Bès ◽  
A. Güell ◽  
N. Fabre ◽  
Ph. Dupui ◽  
G. Victor ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Grey Matter ◽  
Normal Subjects ◽  
Striking Difference ◽  
Inhalation Technique ◽  
Age Group ◽  
Invasive Techniques ◽  
Matter Flow ◽  
Made In

Cerebral blood flow (grey matter flow) in parkinsonism requires further investigation. The noninvasive method of 133Xe inhalation permits study of larger numbers of subjects than previously used invasive techniques such as the intracarotid 133Xe injection method. Measurements were made in this laboratory in 30 subjects having Parkinson's disease. Mean hemispheric blood flow (F1) values were 70.4 ± 9.3 ml/100 g/min, compared to 76.3 for a group of age-matched normal subjects, which is a decrease of −7.8%. The most striking difference was the loss of the “hyperfrontal distribution” in parkinsonism. The prefrontal F1 values were only 1.8% greater than the hemisphere grey matter flow, compared with 8.5% in controls of a similar age group.

Regional Cerebral Blood Flow and Lateralized Hemispheric Dysfunction in Depression

1983 ◽  
Vol 143 (2) ◽  
pp. 128-132 ◽  
Author(s):  
P. Uytdenhoef ◽  
P. Portelange ◽  
J. Jacquy ◽  
G. Charles ◽  
P. Linkowski ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Major Depression ◽  
Regional Cerebral Blood Flow ◽  
Cerebral Metabolism ◽  
Normal Subjects ◽  
Regional Cerebral Blood ◽  
Cerebral Dysfunction ◽  
Bipolar Patients

SummaryCerebral blood flow is known as an indicator of cerebral metabolism. Using the 133Xenon inhalation method, we studied the regional cerebral blood flow (r-CBF) in patients with different subtypes of depression and in remission. A left frontal hypervascularization and a right posterior hypovascularization were found in major depressives, compared to normal subjects, minor depressives, and normothymic bipolar patients. These results tend to confirm the existence of cerebral dysfunction in both hemispheres in major depression, as reported by other authors using different techniques.

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