When and How Often Is It Necessary to Prepare Hyperthyroid Patients for 131I Therapy with Antithyroid Drugs?

Abstract. Thyroid function and thyroid gland volume, ultrasonically determined, were investigated in 27 hyperthyroid patients with solitary autonomous thyroid nodules before and during one year after 131I-treatment. Total thyroid volume decreased gradually from 40.9 ± 3.5 ml (mean ± sem) before treatment to 23.9 ± 1.8 ml (P < 0.001) at 3 months after 131I-treatment. No further change was observed. All but two patients received only one dose of 131I, and in spite of a significant decrease also of the non-adenoma side of the gland, none became hypothyroid. We conclude that 131I-therapy has an important place in the treatment of solitary autonomous thyroid nodules since all our patients became euthyroid within 3 months, only 2 of 27 patients needed more than one dose of 131I, no cases of hypothyroidism occurred, and thyroid volume was substantially decreased.

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PRODUCTION OF ATP IN LEUKOCYTE MITOCHONDRIA FROM HYPERTHYROID PATIENTS BEFORE AND AFTER TREATMENT WITH A β-ADRENERGIC BLOCKER AND ANTITHYROID DRUGS

Acta Endocrinologica ◽

10.1530/acta.0.0660606 ◽

1971 ◽

Vol 66 (4) ◽

pp. 606-610

Author(s):

M. Jemelin ◽

J. Frei ◽

B. Scazziga

Keyword(s):

Adenosine Triphosphate ◽

Antithyroid Drug ◽

Antithyroid Drugs ◽

Enzymatic Method ◽

Before And After ◽

Adrenergic Blocker ◽

Adenosine Triphosphate Production ◽

Hyperthyroid Patients

ABSTRACT The aerobic production of adenosine-triphosphate in leukocyte mitochondria from hyperthyroid patients was measured with an enzymatic method to detect firstly differences between normal and hyperthyroid subjects, and secondly differences between non-treated and treated hyperthyroid patients. The treatment consisted of either a β-adrenergic blocker or an antithyroid drug. Adenosine-triphosphate production is significantly decreased in hyperthyroidism and increases after treatment but does not reach the normal levels.

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TSH Receptor Antibody in Hyperthyroid Patients due to Graves' Disease Treated with Antithyroid Drugs

Folia Endocrinologica Japonica ◽

10.1507/endocrine1927.67.12_1295 ◽

1991 ◽

Vol 67 (12) ◽

pp. 1295-1308 ◽

Cited By ~ 1

Author(s):

Takashi YAMADA

Keyword(s):

Tsh Receptor ◽

Antithyroid Drugs ◽

Graves Disease ◽

Receptor Antibody ◽

Tsh Receptor Antibody ◽

Hyperthyroid Patients

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Clinical and biochemical changes following 131I therapy for hyperthyroidism in patients not pretreated with antithyroid drugs

The Netherlands Journal of Medicine ◽

10.1016/s0300-2977(99)00066-2 ◽

1999 ◽

Vol 55 (5) ◽

pp. 215-221 ◽

Cited By ~ 23

Author(s):

J Koornstra

Keyword(s):

Biochemical Changes ◽

131I Therapy ◽

Antithyroid Drugs

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Effects of drugs on the efficacy of radioiodine (131I) therapy in hyperthyroid patients

Archives of Medical Science ◽

10.5114/aoms.2010.13499 ◽

2010 ◽

Vol 1 ◽

pp. 4-10 ◽

Cited By ~ 3

Author(s):

Lidia Oszukowska ◽

Małgorzata Knapska-Kucharska ◽

Andrzej Lewiński

Keyword(s):

131I Therapy ◽

Hyperthyroid Patients

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EVALUATION OF THE RELATIONSHIP BETWEEN LONG-ACTING THYROID STIMULATOR, CLINICAL AND BIOLOGICAL THYROTOXICOSIS AND EXOPHTHALMOS

Acta Endocrinologica ◽

10.1530/acta.0.0580581 ◽

1968 ◽

Vol 58 (4) ◽

pp. 581-592 ◽

Cited By ~ 10

Author(s):

M. Bonnyns ◽

N. Demeester-Mirkine ◽

R. Calay ◽

P. A. Bastenie

Keyword(s):

Antithyroid Drugs ◽

Thyroglobulin Antibodies ◽

Quantitative Correlation ◽

Modified Method ◽

Long Acting ◽

Relationship Of ◽

The Relationship ◽

Hyperthyroid Patients ◽

Ocular Signs ◽

Pretibial Myxoedema

ABSTRACT Long-Acting Thyroid Stimulator (LATS) determinations were performed on the unconcentrated serum of 92 hyperthyroid patients, using the slightly modified method of McKenzie. A positive LATS response was found in 27 per cent of patients with active thyrotoxicosis, in 55 per cent of patients with residual hyperthyroidism after 131 iodine therapy, in 63 per cent of patients with progressive exophthalmos and in 4 of the 4 patients with pretibial myxoedema. In active thyrotoxicosis, the incidence of LATS was the same in the untreated patients (26%) as in the patients insufficiently treated with antithyroid drugs (27%). In untreated and insufficiently treated patients, exophthalmos, LATS and thyroglobulin antibodies (TGA) were more frequently found in the younger patients. There was a quantitative correlation between the response to LATS and pretibial myxoedema. No relation was found between level of LATS and the severity of ocular signs in progressive exophthalmos or between level of LATS and the biological parameters of the thyroid function in active thyrotoxicosis: cholesterol, PB127I, 131I uptake tests and PB131I. In view of these data, it seems that the relationship of LATS to thyrotoxicosis and/or exophthalmos cannot be considered as a directly causal factor.

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Resistin levels in hyperthyroid patients before and after restoration of thyroid function: relationship with body weight and body composition

Acta Endocrinologica ◽

10.1530/eje.1.01963 ◽

2005 ◽

Vol 153 (2) ◽

pp. 217-221 ◽

Cited By ~ 14

Author(s):

Gerasimos E Krassas ◽

Nikolaos Pontikides ◽

Kostas Loustis ◽

Georgios Koliakos ◽

Theodoros Constantinidis ◽

...

Keyword(s):

Body Weight ◽

Waist Circumference ◽

Thyroid Hormones ◽

Body Fat ◽

Energy Homeostasis ◽

Peptide Hormone ◽

Antithyroid Drugs ◽

Anthropometric Parameters ◽

Before And After ◽

Hyperthyroid Patients

Background: Resistin is a recently discovered peptide hormone that belongs to a family of tissue-specific resistin-like molecules. To date, very few studies have reported on resistin concentrations in hyperthyroid patients, and they present controversial results. Objectives: To undertake a controlled, prospective study to investigate resistin concentrations in hyperthyroidism before and after restoration of euthyroidism and to correlate the results with body weight, body fat, waist circumference and body mass index (BMI). Patients and Methods: A total of 43 hyperthyroid patients (12 men and 31 women) were investigated, in addition to 23 controls. Anthropometric parameters and resistin concentrations were measured. All the patients commenced taking antithyroid drugs and 3–4 months later the same investigations were performed in 36 of the 43 individuals. Results: Hyperthyroid patients exhibited increased resistin concentrations in comparison with controls. Normalization of thyroid hormones was accompanied by a significant decrease in resistin concentration. A sex difference was also found, men showing a significant decrease in resistin concentrations, whereas in women no such difference was found. Resistin concentrations did not correlate with different anthropometric parameters, age and thyroid hormones, either before or after treatment. Conclusions: This study demonstrates for the first time that, although resistin concentrations are increased in hyperthyroidism, they are not associated with body weight, body fat, waist circumference or BMI, which makes it unlikely that resistin plays a crucial part in thermogenesis and energy homeostasis in thyrotoxic patients.

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Serum thyrotropin-receptor autoantibodies levels after I therapy in Graves' patients: effect of pretreatment with methimazole evaluated by a prospective, randomized study

Acta Endocrinologica ◽

10.1530/eje.0.1510467 ◽

2004 ◽

pp. 467-474 ◽

Cited By ~ 18

Author(s):

VA Andrade ◽

JL Gross ◽

AL Maia

Keyword(s):

Randomized Study ◽

Antithyroid Drugs ◽

131I Treatment ◽

Baseline Values ◽

The Mean ◽

Immunomodulatory Action ◽

To Receive ◽

Hyperthyroid Patients ◽

Clinical Trial Methods

OBJECTIVE: Radioiodine therapy (131I) in hyperthyroid Graves' disease is generally followed by a transitory increase in levels of thyrotropin receptors antibodies (TRAb). Immunosuppressive effects of antithyroid drugs are still a matter of debate. In this study we evaluated the effect of methimazole pretreatment on the TRAb boost induced by 131I. DESIGN: A randomized, prospective clinical trial. METHODS: 61 patients were randomly assigned to receive 131I alone (32 patients) or 131I plus pretreatment with methimazole (30 mg/day; 29 patients). Serum TRAb levels were measured on the day of 131I dosing (D0), and at 1, 3, 6 and 12 months after 131I administration. RESULTS: The mean serum TRAb levels decreased significantly from baseline to D0 in patients treated with methimazole (80.8 vs 48.8 U/l; P<0.05). After 131I treatment, TRAb levels increased at 3 months (48.8 to 60 U/l; 19%) and they were still elevated at 6 months compared with D0 values (99.9 U/l; 105%). Thereafter, TRAb levels decreased to baseline values (47.8 U/l) at 12 months. In hyperthyroid patients, TRAb levels increased significantly from D0 to 1 month (45.0 to 78 U/l; 73%) reaching their highest levels at 3 months (225 U/l; 400%). After this, we observed a progressive decrease to the baseline levels at 12 months (40.0 U/l). The course of TRAb levels after 131I treatment was significantly different between the two groups (P<0.05). Multiple regression analysis identified serum TRAb levels on D0 as independent predictors of TRAb increment after 131I therapy (r2=0.34; P=0.001). A higher increment in serum TRAb levels was associated with hypothyroidism after 1 year of follow-up. CONCLUSION: Methimazole pretreatment attenuates the 131I-induced rise in serum TRAb levels. The effects of methimazole could be attributed to a direct immunomodulatory action or may be due to its effects on the control of hyperthyroidism, which is a known cause of immune dysregulation.

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Heart Rate Variability in Hyperthyroidism

Journal of Bangladesh Society of Physiologist ◽

10.3329/jbsp.v4i2.4172 ◽

1970 ◽

Vol 4 (2) ◽

pp. 51-57 ◽

Cited By ~ 2

Author(s):

Md Rasel Kabir ◽

Noorzahan Begum ◽

Sultana Ferdousi ◽

Selina Begum ◽

Taskina Ali

Keyword(s):

Heart Rate ◽

Heart Rate Variability ◽

Nervous Activity ◽

Cross Sectional Study ◽

Antithyroid Drugs ◽

Cross Sectional ◽

Adequate Treatment ◽

Autonomic Nervous ◽

Hyperthyroid Patients ◽

Mean Heart Rate

Background: Hyperthyroidism is associated with altered cardiac autonomic nervous activity (CANA). Heart Rate Variability (HRV) analysis is a promising technique to quantify CANA and therefore can be done in hyperthyroidism. Objective: To observe the HRV parameters in patients with hyperthyroidism to find out the influence of excess thyroid hormone on cardiac autonomic nervous activities. Method: The cross sectional study was carried out on 60 hyperthyroid patients (groupB) aged 30-50 years in the Department of Physiology, BSMMU, Dhaka from 1st July 2007 to 30th June 2008. Age and sex matched 20 apparently healthy euthyroids were also studied for comparison (group A). On the basis of treatment, they were further divided into group B1 consisting of 30 untreated newly diagnosed patients and group B2 consisting of 30 hyperthyroid patients treated with antithyroid drugs for at least 2 months. The patients were selected from the Out Patient Department of Endocrinology, BSMMU, Dhaka. To assess thyroid status, serum TSH and serum FT4 levels were measured by AxSym system and time domain measures of HRV such as mean R-R interval, mean heart rate, SDNN and RMSSD were assessed from 5 minute (short term) ECG recording by a polygraph. For statistical analysis Mann-Whitney U test was done. Results: Mean R-R interval was significantly (P<0.001) lower but mean heart rate was significantly (P<0.001) higher in untreated patients than those of treated and euthyroids subjects. These values were found almost similar when compared between euthyroids and treated hyperthyroids. Similarly SDNN and RMSSD were significantly lower in untreated hyperthyroids than both euthyroids (P<0.001) and treated hyperthyroids (P<0.01). Conclusion: This study concluded that decreased vagal modulation on heart rate may occur in hyperthyroidism, which may be restored following adequate treatment of the disease. Keywords: HRV, R-R Interval, Heart rate, RMSSD, Hyperthyrodism DOI: 10.3329/jbsp.v4i2.4172 J Bangladesh Soc Physiol. 2009 Dec;4(2): 51-57

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