Resistin levels in hyperthyroid patients before and after restoration of thyroid function: relationship with body weight and body composition

Background: Resistin is a recently discovered peptide hormone that belongs to a family of tissue-specific resistin-like molecules. To date, very few studies have reported on resistin concentrations in hyperthyroid patients, and they present controversial results. Objectives: To undertake a controlled, prospective study to investigate resistin concentrations in hyperthyroidism before and after restoration of euthyroidism and to correlate the results with body weight, body fat, waist circumference and body mass index (BMI). Patients and Methods: A total of 43 hyperthyroid patients (12 men and 31 women) were investigated, in addition to 23 controls. Anthropometric parameters and resistin concentrations were measured. All the patients commenced taking antithyroid drugs and 3–4 months later the same investigations were performed in 36 of the 43 individuals. Results: Hyperthyroid patients exhibited increased resistin concentrations in comparison with controls. Normalization of thyroid hormones was accompanied by a significant decrease in resistin concentration. A sex difference was also found, men showing a significant decrease in resistin concentrations, whereas in women no such difference was found. Resistin concentrations did not correlate with different anthropometric parameters, age and thyroid hormones, either before or after treatment. Conclusions: This study demonstrates for the first time that, although resistin concentrations are increased in hyperthyroidism, they are not associated with body weight, body fat, waist circumference or BMI, which makes it unlikely that resistin plays a crucial part in thermogenesis and energy homeostasis in thyrotoxic patients.

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Effect of ellagic acid on body fat and triglyceride reduction in healthy overweight volunteers: a randomized, double-blind, placebo-controlled parallel group study

Functional Foods in Health and Disease ◽

10.31989/ffhd.v10i4.702 ◽

2020 ◽

Vol 10 (4) ◽

pp. 180

Author(s):

Yoshiaka Shiojima

Keyword(s):

Body Weight ◽

Waist Circumference ◽

Body Fat ◽

Visceral Fat ◽

Ellagic Acid ◽

Hip Circumference ◽

Anthropometric Parameters ◽

Double Blind ◽

Irvingia Gabonensis ◽

Main Meal

Background: Worldwide, those categorized as overweight or obese are increasing at an alarming rate, posing a serious public health problem. Current management methods vary, ranging from surgery, dieting and exercise, to the use of synthetic and natural compounds. Previous studies reported the use of an Irvingia gabonensis extract containing ellagic acid in reducing weight and other related parameters in overweight participants. The present study investigated the efficacy of ellagic acid on anthropometric parameters as well as body fat ratio and blood triglyceride levels in otherwise healthy overweight Japanese adults.Participants and Methods: Overall, 32 participants (23 males and 9 females) aged between 20 and 64 years with a BMI of 25 or more but less than 30 kg/m2 and a visceral fat area of 80 cm2 or more were included in this randomized double-blind clinical trial. The 20-week intervention involved two groups of participants -placebo group and ellagic acid (3.0 mg per day) group. The placebo or ellagic acid was taken daily with water 30 minutes before the main meal. At baseline (T0) and at 6 and 12 weeks, anthropometric measurements (body weight, BMI, body fat ratio, waist circumference, hip circumference), CT scans and blood triglyceride levels were measured. Results: Compared to the placebo, ellagic acid brought about statistically significant reductions in body fat ratio, triglycerides, body weight, BMI, waist circumference, hip circumference and visceral fat over the twelve-week trial period.Conclusion: The use of 3.0 mg ellagic acid daily for a 12-week period was effective in reducing body fat ratio and blood triglycerides as well as other anthropometric parameters, confirming the potential use of ellagic acid in the management of overweight patients. Keywords: Ellagic acid, Irvingia gabonensis, overweight, obesity, body fat, triglyceride, body weight, metabolic syndrome.

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Effects of Triphala on Lipid and Glucose Profiles and Anthropometric Parameters: A Systematic Review

Journal of Evidence-Based Integrative Medicine ◽

10.1177/2515690x211011038 ◽

2021 ◽

Vol 26 ◽

pp. 2515690X2110110

Author(s):

Wiraphol Phimarn ◽

Bunleu Sungthong ◽

Hiroyuki Itabe

Keyword(s):

Body Mass Index ◽

Body Weight ◽

Blood Glucose ◽

Waist Circumference ◽

Lipid Profile ◽

Body Mass ◽

The Body ◽

Current Evidence ◽

Diabetic Patients ◽

Anthropometric Parameters

Aim. The efficacy of triphala on lipid profile, blood glucose and anthropometric parameters and its safety were assessed. Methods. Databases such as PubMed, ScienceDirect, Web of Science, and Thai Library Integrated System (ThaiLIS) were systematically searched to review current evidence of randomized controlled trials (RCT) on triphala. RCTs investigating the safety and efficacy of triphala on lipid profile, blood glucose and anthropometric parameters were included. Study selection, data extraction, and quality assessment were performed independently by 2 authors. Results. Twelve studies on a total of 749 patients were included. The triphala-treated groups showed significantly reduced low-density lipoprotein-cholesterol, total cholesterol and triglyceride in 6 studies. Five RCTs demonstrated triphala-treated groups led to statistically significant decrease in body weight, body mass index and waist circumference of obese patients. Moreover, triphala significantly decreased fasting blood glucose level in diabetic patients but not in people without diabetes. No serious adverse event associated with triphala was reported during treatment. Conclusions. This review summarized a current evidence to show triphala might improve the lipid profile, blood glucose, the body weight, body mass index and waist circumference under certain conditions. However, large well-designed RCTs are required to confirm this conclusion.

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The Influence of Age, Sex and Body Mass Index on the Effectiveness of Brisk Walking for Obesity Management in Adults: A Systematic Review and Meta-Analysis

Journal of Physical Activity and Health ◽

10.1123/jpah.2016-0064 ◽

2017 ◽

Vol 14 (5) ◽

pp. 389-407 ◽

Cited By ~ 5

Author(s):

Leon Mabire ◽

Ramakrishnan Mani ◽

Lizhou Liu ◽

Hilda Mulligan ◽

David Baxter

Keyword(s):

Body Mass Index ◽

Body Weight ◽

Waist Circumference ◽

Body Fat ◽

Fat Mass ◽

Fat Free Mass ◽

Body Fat Percentage ◽

Brisk Walking ◽

Obesity Management ◽

Fat Percentage

Background:Brisk walking is the most popular activity for obesity management for adults. We aimed to identify whether participant age, sex and body mass index (BMI) influenced the effectiveness of brisk walking.Methods:A search of 9 databases was conducted for randomized controlled trials (RCTs). Two investigators selected RCTs reporting on change in body weight, BMI, waist circumference, fat mass, fat-free mass, and body fat percentage following a brisk walking intervention in obese adults.Results:Of the 5072 studies screened, 22 met the eligibility criteria. The pooled mean differences were: weight loss, –2.13 kg; BMI, –0.96 kg/m2; waist circumference, –2.83 cm; fat mass, –2.59 kg; fat-free mass, 0.29 kg; and body fat percentage, –1.38%. Meta-regression of baseline BMI showed no effect on changes.Conclusions:Brisk walking can create a clinically significant reduction in body weight, BMI, waist circumference, and fat mass for obese men and women aged under 50 years. Obese women aged over 50 years can achieve modest losses, but gains in fat-free mass reduce overall change in body weight. Further research is required for men aged over 50 years and on the influence of BMI for all ages and sexes.

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An open study of the effectiveness of a multi-component weight-loss intervention for adults with intellectual disabilities and obesity

British Journal Of Nutrition ◽

10.1017/s0007114510005362 ◽

2011 ◽

Vol 105 (10) ◽

pp. 1553-1562 ◽

Cited By ~ 50

Author(s):

Craig A. Melville ◽

Susan Boyle ◽

Susan Miller ◽

Susan Macmillan ◽

Victoria Penpraze ◽

...

Keyword(s):

Weight Loss ◽

Body Weight ◽

Waist Circumference ◽

Intellectual Disabilities ◽

Sedentary Behaviour ◽

Energy Deficit ◽

Controlled Study ◽

Weight Loss Intervention ◽

Before And After ◽

Adults With Intellectual Disabilities

Adults with intellectual disabilities experience high rates of obesity. Despite this higher risk, there is little evidence on the effectiveness of weight-loss interventions for adults with intellectual disabilities and obesity. The present study examined the effectiveness of the TAKE 5 multi-component weight-loss intervention. Adults with obesity were invited using specialist intellectual disability services to participate in the study. Obesity was defined as a BMI of 30 kg/m2 or greater. TAKE 5 included a daily energy-deficit diet of 2510 kJ (600 kcal), achieved via a personalised dietary prescription. Participants' body weight, BMI, waist circumference and levels of physical activity and sedentary behaviour were measured before and after the intervention. A total of fifty-four individuals consented to participate, of which forty-seven (87 %) completed the intervention in the study period. There was a significant decrease in body weight (mean difference − 4·47 (95 % CI − 5·91, − 3·03) kg; P < 0·0001), BMI ( − 1·82 (95 % CI − 2·36, − 1·29) kg/m2; P < 0·0001), waist circumference ( − 6·29 (95 % CI − 7·85, − 4·73) cm; P < 0·0001) and daily sedentary behaviour of participants ( − 41·40 (95 % CI − 62·45, − 20·35) min; P = 0·00 034). Of the participants who completed the intervention, seventeen (36·2 %) lost 5 % or more of their initial body weight. Findings from the study suggest that TAKE 5 is an effective weight-loss intervention for adults with intellectual disabilities and obesity. The effectiveness of TAKE 5 should be examined further in a controlled study.

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PRODUCTION OF ATP IN LEUKOCYTE MITOCHONDRIA FROM HYPERTHYROID PATIENTS BEFORE AND AFTER TREATMENT WITH A β-ADRENERGIC BLOCKER AND ANTITHYROID DRUGS

Acta Endocrinologica ◽

10.1530/acta.0.0660606 ◽

1971 ◽

Vol 66 (4) ◽

pp. 606-610

Author(s):

M. Jemelin ◽

J. Frei ◽

B. Scazziga

Keyword(s):

Adenosine Triphosphate ◽

Antithyroid Drug ◽

Antithyroid Drugs ◽

Enzymatic Method ◽

Before And After ◽

Adrenergic Blocker ◽

Adenosine Triphosphate Production ◽

Hyperthyroid Patients

ABSTRACT The aerobic production of adenosine-triphosphate in leukocyte mitochondria from hyperthyroid patients was measured with an enzymatic method to detect firstly differences between normal and hyperthyroid subjects, and secondly differences between non-treated and treated hyperthyroid patients. The treatment consisted of either a β-adrenergic blocker or an antithyroid drug. Adenosine-triphosphate production is significantly decreased in hyperthyroidism and increases after treatment but does not reach the normal levels.

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Energy Homeostasis and Body Weight before and after Cessation of Block and Replacement Therapy in Euthyroid Patients with Graves' Disease

International Journal of Endocrinology ◽

10.1155/2011/715370 ◽

2011 ◽

Vol 2011 ◽

pp. 1-7 ◽

Cited By ~ 2

Author(s):

Lars P. Klieverik ◽

Andries Kalsbeek ◽

Mariëtte T. Ackermans ◽

Hans P. Sauerwein ◽

Wilmar M. Wiersinga ◽

...

Keyword(s):

Body Weight ◽

Replacement Therapy ◽

Energy Homeostasis ◽

Significant Positive Correlation ◽

Resting Energy Expenditure ◽

Graves Disease ◽

Serum Free ◽

Before And After ◽

Relative Change ◽

Positive Determinant

Patients with Graves' hyperthyroidism (GH) treated with a combination of thyrostatic drugs and T4, that is, block and replacement therapy (BRT), often report body weight (BW) gain. We aimed to determine changes in BW and energy metabolism upon cessation of BRT in these patients, and to identify possible endocrine determinants. We analysed 22 patients with GH (i) during BRT, and (ii) 12 weeks after BRT cessation. Patients were euthyroid at both visits. There were no differences in BW or resting energy expenditure (REE) between visits. At visit 1, after 13.5 (9.5–48.0) months of BRT, serum free (F)T4correlated positively with REE (, ) and negatively with body fat % (, ). Plasma FT3and FT3/FT4ratio showed an increase 12 w after cessation of BRT (20%, and 16%, , resp.). Moreover, the relative change in FT3/FT4ratio showed a significant, positive correlation with the relative change in REE between the 2 visits (, ). In conclusion, serum FT4determines REE in euthyroid patients with GH treated with BRT. Twelve weeks after BRT cessation, BW and energy homeostasis are unaltered. However, as serum FT3/FT4ratio increases after cessation of BRT, which is a positive determinant of changes in REE, a longer term BW decrease is likely to occur.

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Intervenção para o controle do peso corporal de adolescentes, utilizando videogames ativos: um estudo piloto

Caderno de Educação Física e Esporte ◽

10.36453/2318-5104.2018.v16.n2.p51 ◽

2018 ◽

Vol 16 (2) ◽

pp. 51-55

Author(s):

Catiana Leila Possamai Romanzini ◽

Beatriz Lara Leile Pavanello ◽

Kessi Cassiane Iarosz ◽

Vinícius Zandonadi Pires

Keyword(s):

Body Weight ◽

Pilot Study ◽

Waist Circumference ◽

Video Games ◽

Anthropometric Measures ◽

Significance Level ◽

Active Video Games ◽

Significant Difference ◽

Active Video ◽

Before And After

Estratégias de intervenção que utilizam exergames que visam o estímulo à prática de atividade física, bem como à redução do tempo em comportamento sedentário, parecem ser caminhos promissores para lidar com o aumento das taxas de obesidade. Este foi o intuito do Projeto de Extensão “Exergaming para a saúde: intervenção para o controle do peso corporal em adolescentes utilizando videogames ativos”, contemplado com fomento do MEC/PROEXT no ano de 2013. O objetivo do estudo foi verificar o efeito de uma intervenção de oito semanas com videogames ativos sobre variáveis relacionadas ao peso corporal de adolescentes. Foi realizado um estudo piloto de intervenção de oito semanas com duração de 60 minutos por sessão, com uso dos exergames. Participaram do estudo oito escolares, com média de idade de 11,5±0,5 anos. Medidas antropométricas antes e após a intervenção foram realizadas. Utilizou-se a estatística descritiva e o teste t pareado, no SPSS 20.0 com nível de significância de p0,05. Observou-se que houve diferença estatisticamente significativa somente na circunferência de cintura (cm) com redução de 2,8 cm (p = 0,028). As demais variáveis analisadas não foram diferentes. O estudo piloto de uma intervenção de oito semanas com videogames ativos demonstrou possibilidade de redução de medidas antropométricas, tais como a circunferência de cintura dos adolescentes. Sugere-se que novos estudos com exergames tenham enfoque neste desfecho em um período mais longo de intervenção e/ou com maior número de sessões durante a semana.ABSTRACT. Intervention for the control of body weight in adolescents using active video games: a pilot study. Intervention strategies that use exergames that aim to stimulate the practice of physical activity, as well as the reduction of the time in sedentary behavior, through promising ways to deal with the increase of obesity rates. This is the way of Extension Project “Exergaming for health: intervention for the control of body weight in adolescents using active video games”, with fomentation of MEC/PROEXT in 2013. The aim of this study was to verify the effect of an eight-week intervention with active video games on variables related to adolescent body weight. An eight-week intervention study with a duration of 60 minutes per session, with use of exergames was performed. Eight schoolchildren participated, with mean age of 11.5±0.5 years. Anthropometric measures before and after the intervention were performed. Descriptive statistics and the non-parametric equivalent of paired t-test were used in SPSS 20.0 with significance level of p0.05. It was observed that there was a significant difference only in waist circumference (cm) with a reduction of 2.8 cm (p = 0.028). The other variables analyzed were not different. The pilot study of an eight-week intervention with active videogames demonstrated the possibility of reducing anthropometric measures, such as the waist circumference of adolescents. We suggested that new studies with exergames focus on this outcome over a longer period of intervention and/or with a larger number of sessions during the week.

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Latihan yoga terhadap berat badan, persen lemak tubuh, dan lingkar perut pada wanita dewasa overweight

Jurnal Gizi Klinik Indonesia ◽

10.22146/ijcn.32150 ◽

2018 ◽

Vol 14 (4) ◽

pp. 131

Author(s):

Putri Nur Fatimah ◽

Fillah Fithra Dieny ◽

Etisa Adi Murbawani ◽

Ahmed Fahmy Arif Tsani

Keyword(s):

Body Weight ◽

Treatment Group ◽

Waist Circumference ◽

Nutrition Education ◽

Body Fat ◽

The Body ◽

Control Group ◽

Weight Percentage ◽

Percentage Of Body Fat ◽

Significant Difference

Background: Obesity caused diabetes and cardiovascular disease. Yoga considered three aspects, physic, emotion and mental that helped in obesity therapy.Objective: This research aimed to explain the influence of yoga excercise on body weight, percent of body fat, waist circumference and waist to hip ratio (WHR) in overweight women.Method: This research applied quasi experiment design by using pre-post test with control group design. The subjects of research were 31 women aged 19-25 years old and divided into 2 groups, treatment group and control group. Treatment group was prepared to do yoga in 60 minutes for 10 times during 20 days and given nutrition education, whereas control group was given nutrition education only. Data body weight and percentage of body fat were measured by bioimpedance analysis; waist circumference and WHR were measured by tape measures; food intake were assessed by food recall and food frequency questionnaire. Data were analyzed using paired t-test and independent t-test.Results: There was a significant difference of body weight before and after intervention in both groups. The body weight on treatment group decreased by 0.81 ± 1.29 kg (p<0.05), while the body weight on the control group increased. Percentage of body fat and waist circumference decreased on both of groups, however treatment group decreased more than the control group. WHR no significant on both of groups. Yoga excercise resulted no significant influences on body weight, percentage of body fat, waist circumference and WHR in overweight women (p>0.05). Conclusion: Obesity women with 10 times yoga had no significant influences on body weight, percentage of body fat, waist circumference and WHR.

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Impact of a program based in eating habits and physiotherapy on anthropometric parameters in patients with coronary artery disease: randomized controlled trial

European Journal of Cardiovascular Nursing ◽

10.1093/eurjcn/zvab060.080 ◽

2021 ◽

Vol 20 (Supplement_1) ◽

Author(s):

E Munoz-Gomez ◽

N Sempere-Rubio ◽

J Blesa ◽

P Iglesias ◽

L Mico ◽

...

Keyword(s):

Waist Circumference ◽

Muscle Mass ◽

Body Fat ◽

Visceral Fat ◽

Eating Habits ◽

Controlled Trial ◽

Hip Circumference ◽

Anthropometric Parameters ◽

Randomized Controlled ◽

Artery Disease

Abstract Funding Acknowledgements Type of funding sources: None. Introduction. On the one hand, physical training such as High intensity interval training (HIIT) and on the other, eating habits, it is often prescribed to patients with coronary artery disease (CAD). Nevertheless, the combination of HIIT and eating habits in CAD with percutaneous coronary intervention (PCI) there is no consensus on using a combined protocol of both. Purpose. The purpose of this study was to evaluate the impact of an HIIT program with eating habits, with a program based in HIIT, on anthropometric parameters in CAD patients with PCI. Methods. A randomized controlled trial was carried out in a hospital. 44 patients with CAD and PCI were recruited. All participants signed an informed consent. Patients were randomly allocated to a HIIT group (HIIT, n = 22, 81.8% men, 62.05 ± 4.9 years) or to a Dietary education and HIIT (DEHIIT) group (n = 22, 81.8% men, 60.2 ± 5.6 years). HIIT consisted of a 3-month physiotherapy program, twice a week for one hour, at 85-95% peak heart rate. DEHIIT consisted of a multidisciplinary program, including the same HIIT program explained, plus eating habits. Body composition (weight, BMI, % body fat, % visceral fat, muscle mass) and waist circumference, hip circumference and Waste-to-Hip Ratio (WHR) were evaluated at baseline and at week 12. Results. At the end of the program, DEHIIT significantly decreased all anthropometrics parameters except muscle mass. The following parameters decreased: weight (p ≤ 0.001), BMI (p ≤ 0.001), body fat (p ≤ 0.001), visceral fat (p ≤ 0.001), waist circumference (p ≤ 0.001), hip circumference (p = 0.043) and WHR (p ≤ 0.001). Instead, the muscle mass increased significantly (p ≤ 0.001). When comparing between groups, DEHIIT did not show significant differences weight (p = 0.575), BMI (p = 0.404), % body fat (p = 0.217), muscle mass (p = 0.508), waist circumference (p = 0.165), hip circumference (p = 0.307), WHR (p = 0.379), except for presenting less visceral fat (p = 0.040) than HIIT. Conclusions HIIT programme with eating habits reducing visceral fat in CAD patients with PCI compared to a HIIT-only program.

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The effects of different caloric restriction diets on anthropometric and cardiometabolic risk factors in overweight and obese females

Vojnosanitetski pregled ◽

10.2298/vsp160408206m ◽

2018 ◽

Vol 75 (1) ◽

pp. 30-38 ◽

Cited By ~ 1

Author(s):

Tatjana Mraovic ◽

Sonja Radakovic ◽

Danijela Ristic-Medic ◽

Vesna Tepsic-Ostojic ◽

Slavica Radjen ◽

...

Keyword(s):

Body Weight ◽

Body Fat ◽

Cardiometabolic Risk ◽

Density Lipoprotein ◽

Energy Requirements ◽

Anthropometric Parameters ◽

Group Iii ◽

Group I ◽

Group Ii ◽

Hs Crp

Background/Aim. Obesity is an established risk factor for numerous chronic diseases. The aim of this study was to investigate the effect of well-balanced different caloric restriction (CR) diets on anthropometric parameters and standard biochemical cardiovascular risk markers [lipid profile, glucose homeostasis and high sensitivity C-reactive protein (hs-CRP)] in overweight/obese females. Methods. Participants (age 20? 40 years) were randomized into 3 different CR diet groups: the group I ? restriction of 20% calories from baseline energy requirements, the group II ? restriction of 50% calories from baseline energy requirements and the group III ? alternating daily diets with 70%/30% restriction. The study lasted 42 weeks. Anthropometric parameters were measured at the start and after 4, 8, 20 and 42 weeks after dietary intervention beginning. Biochemical markers were determined at baseline and after 20 and 42 weeks from dietary restriction start. Results. Body weight, body mass index (BMI), waist circumference (WC) and body fat (in %), in the different CR diet groups significantly decreased after 42 weeks. Body weight was less 11 kg in the group I and 12 kg in the groups II and III. WC was reduced by 11 cm in the groups I and III and by 10 cm in the group II. Different CR diets had the same effects on body fat (a reduction of 15% of body fat). Total cholesterol decreased by 7% in the group I and by 8% in the group III. Low density lipoprotein (LDL) cholesterol decreased by 14% in the group I and by 13% in group III. There were no significant changes in total and LDLcholesterol levels in the group II. The atherogenic index presented as trigliceride/high density lipoprotein (TG/HDL) ratio decreased by 0.22 in the group I, by 0.25 in the group II and by 0.32 in the group III. Various CR diets had the same effects on reducing the hs-CRP levels. Conclusion. Different CR diets with the same macronutrient content are equally effective in reducing body weight, WC and body fat, improve cardiometabolic risk factors and decrease level of proinflammatory hs-CRP in overweight/obese females.

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