The Role of Clinical Chemistry in Preventive Medicine

1989 ◽  
pp. 33-42
Author(s):  
K. Miyai
Keyword(s):  
Preventive Medicine ◽  
Clinical Chemistry

Turnaround times and modes of reporting critical results in Asian laboratories

2021 ◽  
pp. 000456322198936
Author(s):  
Tony Badrick ◽  
Mohamed Saleem ◽  
Wesley Wong
Keyword(s):  
Quality Improvement ◽  
Performance Index ◽  
Clinical Chemistry ◽  
Reporting Quality ◽  
Turnaround Time ◽  
Timely Manner ◽  
Phone Calls ◽  
Key Performance Index ◽  
Critical Results

Background Reporting critical results in a timely manner is a crucial role of clinical laboratories. Traditionally, these results were reported using the phone or fax system. However, there are now other modes of communication for this reporting. Quality improvement in any organization is driven by detection of errors and benchmarking against peers. In the case of critical result reporting, there are few current widely used Benchmarking schemes. Methods The Roche Clinical Chemistry Benchmarking Survey in 2019 added questions about critical result reporting including the mode of communication and turnaround time key performance index. This survey includes over 1100 laboratories from 20 countries. Results The survey revealed a range of communication strategies with phone calls still the commonest followed by email. The key performance index for most laboratories was less than 10 min. Conclusion Benchmarking can provide key information for quality improvement activities, particularly pre- and postanalytical.

Transporters, TBC1D4, and ARID5B Variants to Explain Glycated Hemoglobin Variability in Patients with Type 2 Diabetes

Pharmacology ◽  
2021 ◽  
pp. 1-9
Author(s):  
Vanessa Gonzalez-Covarrubias ◽  
Héctor Sánchez-Ibarra ◽  
Karla Lozano-Gonzalez ◽  
Sergio Villicaña ◽  
Tomas Texis ◽  
...  
Keyword(s):  
Genetic Variants ◽  
Glucose Control ◽  
Plasma Levels ◽  
Prediction Models ◽  
Glycated Hemoglobin ◽  
Clinical Chemistry ◽  
Diabetic Patients ◽  
Genetic Associations ◽  
Hemoglobin Variability

<b><i>Introduction:</i></b> Genetic variants could aid in predicting antidiabetic drug response by associating them with markers of glucose control, such as glycated hemoglobin (HbA1c). However, pharmacogenetic implementation for antidiabetics is still under development, as the list of actionable markers is being populated and validated. This study explores potential associations between genetic variants and plasma levels of HbA1c in 100 patients under treatment with metformin. <b><i>Methods:</i></b> HbA1c was measured in a clinical chemistry analyzer (Roche), genotyping was performed in an Illumina-GSA array and data were analyzed using PLINK. Association and prediction models were developed using R and a 10-fold cross-validation approach. <b><i>Results:</i></b> We identified genetic variants on <i>SLC47A1, SLC28A1, ABCG2, TBC1D4,</i> and <i>ARID5B</i> that can explain up to 55% of the interindividual variability of HbA1c plasma levels in diabetic patients under treatment. Variants on <i>SLC47A1</i>, <i>SLC28A1</i>, and <i>ABCG2</i> likely impact the pharmacokinetics (PK) of metformin, while the role of the two latter can be related to insulin resistance and regulation of adipogenesis. <b><i>Conclusions:</i></b> Our results confirm previous genetic associations and point to previously unassociated gene variants for metformin PK and glucose control.

Evidence Based Medical Prevention: International Experience

2016 ◽  
pp. 34-37
Author(s):  
Olha Puzanovа
Keyword(s):  
Health Care ◽  
Preventive Medicine ◽  
Scientific Information ◽  
International Experience ◽  
Evidence Based ◽  
Task Forces ◽  
Cochrane Reviews ◽  
The Us ◽  
Based Medicine

The objective: was to study the international experience of evidence based preventive medicine development as well as to estimate its perspectives in Ukraine. Patients and methods. Main principles and methods of scientific knowledge and research have been used including universal ones, methods of systemic approach, quantitative and qualitative information analysis, classification and systematization of theoretical and empirical data, hystorical and logical methods, health statistics as well). In total 529 scientific information sources have been studied, particularly a number of evidence based medicine (EBM) computer databases, special task forces recommendations and Cochrane reviews on prevention, Register of medical and technological documents for health care standards in Ukraine et al. Results. The contribution of foreign scientific schools in the development of EBM has been determined, as well as the crucial role of scientific works carried out in the US and Great Britain in 1930–80s as to the development of evidence based preventive medicine. The international experience of the development and functioning of evidence based practice centers’ and special task forces on prevention has been summarized, as the experience of the development and implementation of recommendations on prevention in primary health care (PHC) in high income countries acceptable for Ukraine. The concept of evidence based prevention has been first proposed. It is revealed, that EBM implementation in Europe has been prioritized in both the field of infectious diseases prevention and PHC, while there are both the development of differentiated evidence based prevention and early evidence based diagnosis in PHC in the US. Conclusion. The results proved importance of taking into consideration of international experience while evidence based PHC is being developed as a priority in Ukraine.

The role of preventive medicine in developing countries.

1990 ◽  
Vol 39 (4) ◽  
pp. 265-269
Author(s):  
Dalmas A. R. Dominicus ◽  
Takashi Akamatsu
Keyword(s):  
Developing Countries ◽  
Preventive Medicine

The Role of Spirituality in Integrative Preventive Medicine

2017 ◽  
Author(s):  
Gary E. Schwartz
Keyword(s):  
Preventive Medicine ◽  
Positive Association ◽  
Well Being ◽  
Religious Practice ◽  
Paradigm Change ◽  
Life After Death ◽  
Spirituality And Health ◽  
The Relationship ◽  
Near Death Experiences

Substantial research documents a positive association between religious practice and improved health and well-being. Research on the relationship between spirituality and health is less developed but also positive. Generally speaking, Western science and medicine explain these positive associations via psychological and social mechanisms rather than spiritual (or “metaphysical”) ones. However, contemporary theory and research in consciousness science, including research on near-death experiences and life after death, are pointing to a profound paradigm change in science, shifting from conventional materialist models of nature and the cosmos to postmaterialist models. This chapter introduces the reader to the emerging postmaterialist paradigm in science and considers some of its important implications for understanding and applying spirituality in integrative preventive medicine.

scholarly journals Drug-Based Gold Nanoparticles Overgrowth for Enhanced SPR Biosensing of Doxycycline

Biosensors ◽  
2020 ◽  
Vol 10 (11) ◽  
pp. 184
Author(s):  
Syed Akif Raza Kazmi ◽  
Muhammad Zahid Qureshi ◽  
Jean-Francois Masson
Keyword(s):  
Colloidal Stability ◽  
Clinical Chemistry ◽  
High Sensitivity ◽  
Au Nanoparticle ◽  
Spr Biosensor ◽  
Frequent Monitoring ◽  
Surface Yield ◽  
Response Enhancement ◽  
Protease Activated Receptor 1

In clinical chemistry, frequent monitoring of drug levels in patients has gained considerable importance because of the benefits of drug monitoring on human health, such as the avoidance of high risk of over dosage or increased therapeutic efficacy. In this work, we demonstrate that the drug doxycycline can act as an Au nanoparticle (doxy-AuNP) growth and capping agent to enhance the response of a surface plasmon resonance (SPR) biosensor for this drug. SPR analysis revealed the high sensitivity of doxy-AuNPs towards the detection of free doxycycline. More specifically, doxy-AuNPs bound with protease-activated receptor-1 (PAR-1) immobilized on the SPR sensing surface yield the response in SPR, which was enhanced following the addition of free doxy (analyte) to the solution of doxy-AuNPs. This biosensor allowed for doxycycline detection at concentrations as low as 7 pM. The study also examined the role of colloidal stability and growth of doxy-AuNPs in relation to the response-enhancement strategy based on doxy-AuNPs. Thus, the doxy-AuNPs-based SPR biosensor is an excellent platform for the detection of doxycycline and demonstrates a new biosensing scheme where the analyte can provide enhancement.

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