Effect of Dietary Phytochemicals on Metabolic Syndrome and Neurological Disorders

Abstract:: Sirtuins are NAD+ dependent enzymes that have a predominant role in neurodegenerative disorders and also regulate the inflammatory process, protein aggregation, etc. The relation between Sirtuins with that of the nervous system and neurodegeneration are widely studied consequently. Sirtuins have a strong role in metabolic syndrome in mitochondria also. The activities of Sirtuins can be altered by using small molecules that would be developed into drugs and it is proven that manipulation of SIRT1 activity influences neurodegenerative disease models. They are especially thrilling since using small molecules, which would be developed into a drug, it is feasible to alter the activities of sirtuins. Different functions of Sirtuins are depended upon their subcellular localization. In this review paper, we are discussing different Sirtuins, differential expression of sirtuins, and expression of sirtuin in the brain and briefly about sirtuin3 (SIRT3).

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Tapping into the Potential of Cinnamon as a Therapeutic Agent in Neurological Disorders and Metabolic Syndrome

Cinnamon ◽

10.1007/978-3-030-54426-3_11 ◽

2020 ◽

pp. 273-305

Author(s):

Hanouf Ismail ◽

Nalaka Wijekoon ◽

Lakmal Gonawala ◽

Stephanie Perera ◽

Shamali Wasala ◽

...

Keyword(s):

Metabolic Syndrome ◽

Neurological Disorders ◽

Therapeutic Agent

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Metabolic syndrome as a risk factor for neurological disorders

Cellular and Molecular Life Sciences ◽

10.1007/s00018-011-0840-1 ◽

2011 ◽

Vol 69 (5) ◽

pp. 741-762 ◽

Cited By ~ 105

Author(s):

Akhlaq A. Farooqui ◽

Tahira Farooqui ◽

Francesco Panza ◽

Vincenza Frisardi

Keyword(s):

Metabolic Syndrome ◽

Risk Factor ◽

Neurological Disorders

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Obesity and cognitive dysfunction

Obesity and metabolism ◽

10.14341/omet201633-8 ◽

2016 ◽

Vol 13 (3) ◽

pp. 3-8

Author(s):

Mariia Vladimirovna Matveeva ◽

Julia Gennadevna Samoylova ◽

Natalija Grigorevna Zhukova

Keyword(s):

Cardiovascular Disease ◽

Metabolic Syndrome ◽

Neurological Disorders ◽

Systematic Data ◽

Obvious Association ◽

Long Time ◽

Leading Position ◽

Biochemical Mechanisms ◽

Per Se

Obesity takes epidemic proportions, encompassing different groups of society. In turn, cerebrovascular pathology holds a leading position in the spectrum of neurological disorders. Researchers indicate a role of obesity in the development of cognitive impairment. However, the cellular and biochemical mechanisms underlying that connection are still poorly understood. In addition, despite the obvious association of obesity with the deterioration of mental activity demonstrated in clinical trials for a long time it was unclear whether these disorders are caused by obesity per se or related conditions, such as metabolic syndrome, diabetes or cardiovascular disease. Currently there is scarse systematic data on a cause-effect relationships of these two pathologies.

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