Lipid Mediators in Metabolic Syndrome and Neurological Disorders

2013 ◽  
pp. 103-141 ◽  
Author(s):  
Akhlaq A. Farooqui
Keyword(s):  
Metabolic Syndrome ◽  
Neurological Disorders ◽  
Lipid Mediators

scholarly journals The Relationship between Eicosanoid Levels and Serum Levels of Metabolic and Hormonal Parameters Depending on the Presence of Metabolic Syndrome in Patients with Benign Prostatic Hyperplasia

2019 ◽  
Vol 16 (6) ◽  
pp. 1006
Author(s):  
Katarzyna Grzesiak ◽  
Aleksandra Rył ◽  
Ewa Stachowska ◽  
Marcin Słojewski ◽  
Iwona Rotter ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Benign Prostatic Hyperplasia ◽  
Free Testosterone ◽  
Serum Levels ◽  
Prostatic Hyperplasia ◽  
Lipid Mediators ◽  
Total Testosterone ◽  
Blood Samples ◽  
Mediators Of Inflammation ◽  
The Relationship

Background: The purpose of our investigation was to analyze the relationship between the serum levels of inflammatory mediators (HETE, HODE) and the levels of selected metabolic and hormonal parameters in patients with benign prostatic hyperplasia (BPH) with regard to concomitant metabolic syndrome (MetS). Methods: The study involved 151 men with BPH. Blood samples were taken for laboratory analysis of the serum levels of metabolic and hormonal parameters. Gas chromatography was performed using an Agilent Technologies 7890A GC System. Results: We found that waist circumference was the only parameter related to the levels of fatty acids, namely: 13(S)-HODE, 9(S)-HODE, 15(S)-HETE, 12(S)-HETE, and 5-HETE. In the patients with BPH and MetS, triglycerides correlated with 9(S)-HODE, 15(S)-HETE, 12(S)-HETE, and 5-HETE, which was not observed in the patients without MetS. Similarly, total cholesterol correlated with 9(S)-HODE, and 15(S)-HETE in the patients with BPH and MetS, but not in those without MetS. In the group of BPH patients with MetS, total testosterone positively correlated with 13(S)-HODE, and free testosterone with 9(S)-HODE. Conclusions: Based on this study, it can be concluded that lipid mediators of inflammation can influence the levels of biochemical and hormonal parameters, depending on the presence of MetS in BPH patients.

scholarly journals Specialized proresolving lipid mediators in humans with the metabolic syndrome after n–3 fatty acids and aspirin

2015 ◽  
Vol 102 (6) ◽  
pp. 1357-1364 ◽  
Author(s):  
Anne E Barden ◽  
Emilie Mas ◽  
Kevin D Croft ◽  
Michael Phillips ◽  
Trevor A Mori
Keyword(s):  
Metabolic Syndrome ◽  
Fatty Acids ◽  
Lipid Mediators ◽  
The Metabolic Syndrome

Sirtuin3 in Neurological Disorders

2020 ◽  
Vol 12 ◽  
Author(s):  
Farhath Sherin ◽  
S. Gomathy ◽  
Shanish Antony
Keyword(s):  
Metabolic Syndrome ◽  
Nervous System ◽  
Small Molecules ◽  
Neurodegenerative Disorders ◽  
Neurological Disorders ◽  
Inflammatory Process ◽  
Review Paper ◽  
Disease Models ◽  
Predominant Role ◽  
The Brain

Abstract:: Sirtuins are NAD+ dependent enzymes that have a predominant role in neurodegenerative disorders and also regulate the inflammatory process, protein aggregation, etc. The relation between Sirtuins with that of the nervous system and neurodegeneration are widely studied consequently. Sirtuins have a strong role in metabolic syndrome in mitochondria also. The activities of Sirtuins can be altered by using small molecules that would be developed into drugs and it is proven that manipulation of SIRT1 activity influences neurodegenerative disease models. They are especially thrilling since using small molecules, which would be developed into a drug, it is feasible to alter the activities of sirtuins. Different functions of Sirtuins are depended upon their subcellular localization. In this review paper, we are discussing different Sirtuins, differential expression of sirtuins, and expression of sirtuin in the brain and briefly about sirtuin3 (SIRT3).

Tapping into the Potential of Cinnamon as a Therapeutic Agent in Neurological Disorders and Metabolic Syndrome

Cinnamon ◽  
2020 ◽  
pp. 273-305
Author(s):  
Hanouf Ismail ◽  
Nalaka Wijekoon ◽  
Lakmal Gonawala ◽  
Stephanie Perera ◽  
Shamali Wasala ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Neurological Disorders ◽  
Therapeutic Agent

Metabolic syndrome as a risk factor for neurological disorders

2011 ◽  
Vol 69 (5) ◽  
pp. 741-762 ◽  
Author(s):  
Akhlaq A. Farooqui ◽  
Tahira Farooqui ◽  
Francesco Panza ◽  
Vincenza Frisardi
Keyword(s):  
Metabolic Syndrome ◽  
Risk Factor ◽  
Neurological Disorders

scholarly journals Obesity and cognitive dysfunction

2016 ◽  
Vol 13 (3) ◽  
pp. 3-8
Author(s):  
Mariia Vladimirovna Matveeva ◽  
Julia Gennadevna Samoylova ◽  
Natalija Grigorevna Zhukova
Keyword(s):  
Cardiovascular Disease ◽  
Metabolic Syndrome ◽  
Neurological Disorders ◽  
Systematic Data ◽  
Obvious Association ◽  
Long Time ◽  
Leading Position ◽  
Biochemical Mechanisms ◽  
Per Se

Obesity takes epidemic proportions, encompassing different groups of society. In turn, cerebrovascular pathology holds a leading position in the spectrum of neurological disorders. Researchers indicate a role of obesity in the development of cognitive impairment. However, the cellular and biochemical mechanisms underlying that connection are still poorly understood. In addition, despite the obvious association of obesity with the deterioration of mental activity demonstrated in clinical trials for a long time it was unclear whether these disorders are caused by obesity per se or related conditions, such as metabolic syndrome, diabetes or cardiovascular disease. Currently there is scarse systematic data on a cause-effect relationships of these two pathologies.

scholarly journals Mike Wakelam: an appreciation

2020 ◽  
Vol 64 (3) ◽  
pp. 397-399
Author(s):  
Bob Michell
Keyword(s):  
Metabolic Syndrome ◽  
Lipid Mediators ◽  
Biologically Active ◽  
Active Metabolites ◽  
Surface Receptors ◽  
Physiological Processes ◽  
Lipid Signalling ◽  
Cells Of Origin ◽  
Activate Cell ◽  
Biologically Active Metabolites

Abstract This issue of Essays in Biochemistry explores lipid mediators — biologically active metabolites formed by enzymic and non-enzymic oxidation of polyunsaturated fatty acids. These can be exported across the cell membrane into the extracellular space, where they activate cell surface receptors to stimulate the cells of origin (autocrine) or nearby cells (paracrine). Lipid mediators are involved in many physiological processes, which may become dysregulated during ageing and in lipid-related diseases such as diabetes, atherosclerosis, arthritis, cancer, Alzheimer’s disease and metabolic syndrome. Following the death in March 2020 of Professor Mike Wakelam, with the loss of his major input into the lipid signalling field, Portland Press and Guest Editors John Harwood and Emyr Lloyd-Evans decided to dedicate this issue to his memory. This Editorial briefly recalls his work and influence.

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