Tapping into the Potential of Cinnamon as a Therapeutic Agent in Neurological Disorders and Metabolic Syndrome

Cinnamon ◽  
2020 ◽  
pp. 273-305
Author(s):  
Hanouf Ismail ◽  
Nalaka Wijekoon ◽  
Lakmal Gonawala ◽  
Stephanie Perera ◽  
Shamali Wasala ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Neurological Disorders ◽  
Therapeutic Agent

scholarly journals Development, Implementation, and Use of a Neurology Therapeutics Committee

2019 ◽  
Vol 6 ◽  
pp. 2329048X1983047
Author(s):  
Edward B. Clark ◽  
Russell J. Butterfield ◽  
Francis M. Filloux ◽  
Joshua L. Bonkowsky
Keyword(s):  
Neurological Disorders ◽  
Therapeutic Agent ◽  
Pediatric Patients ◽  
Third Party ◽  
Insurance Companies ◽  
Clinical Implementation ◽  
Appropriate Use ◽  
Therapy Choice ◽  
Financial Burdens ◽  
Therapeutics Committee

Innovative therapeutics are transforming care of children with previously untreatable neurological disorders. However, there are challenges in the use of new therapies: the medicine may not be effective in all patients, administration may not be tolerated, and matching therapy choice to patient is complex. Finally, costs are high, which imposes financial burdens on insurance companies, families, and the health-care system. Our objective was to address challenges for clinical implementation of the new therapeutics. We sought to develop a process that would be personalized for patient and disease, encourage appropriate use of a therapeutic agent while mitigating pressure on a clinician to prescribe the therapy in all instances, and assist third-party payers in approving therapeutic use based on safety and efficacy. We report our creation of a Neurology Therapeutics Committee for pediatric patients. We review the committee’s mechanisms, describe its use and report outcomes, and suggest the Neurology Therapeutics Committee’s broader applicability.

Sirtuin3 in Neurological Disorders

2020 ◽  
Vol 12 ◽  
Author(s):  
Farhath Sherin ◽  
S. Gomathy ◽  
Shanish Antony
Keyword(s):  
Metabolic Syndrome ◽  
Nervous System ◽  
Small Molecules ◽  
Neurodegenerative Disorders ◽  
Neurological Disorders ◽  
Inflammatory Process ◽  
Review Paper ◽  
Disease Models ◽  
Predominant Role ◽  
The Brain

Abstract:: Sirtuins are NAD+ dependent enzymes that have a predominant role in neurodegenerative disorders and also regulate the inflammatory process, protein aggregation, etc. The relation between Sirtuins with that of the nervous system and neurodegeneration are widely studied consequently. Sirtuins have a strong role in metabolic syndrome in mitochondria also. The activities of Sirtuins can be altered by using small molecules that would be developed into drugs and it is proven that manipulation of SIRT1 activity influences neurodegenerative disease models. They are especially thrilling since using small molecules, which would be developed into a drug, it is feasible to alter the activities of sirtuins. Different functions of Sirtuins are depended upon their subcellular localization. In this review paper, we are discussing different Sirtuins, differential expression of sirtuins, and expression of sirtuin in the brain and briefly about sirtuin3 (SIRT3).

scholarly journals Argan Oil as an Effective Nutri-Therapeutic Agent in Metabolic Syndrome: A Preclinical Study

2017 ◽  
Vol 18 (11) ◽  
pp. 2492 ◽  
Author(s):  
Adil El Midaoui ◽  
Youssef Haddad ◽  
Younes Filali-Zegzouti ◽  
Réjean Couture
Keyword(s):  
Metabolic Syndrome ◽  
Therapeutic Agent ◽  
Preclinical Study ◽  
Argan Oil

Metabolic syndrome as a risk factor for neurological disorders

2011 ◽  
Vol 69 (5) ◽  
pp. 741-762 ◽  
Author(s):  
Akhlaq A. Farooqui ◽  
Tahira Farooqui ◽  
Francesco Panza ◽  
Vincenza Frisardi
Keyword(s):  
Metabolic Syndrome ◽  
Risk Factor ◽  
Neurological Disorders

scholarly journals Obesity and cognitive dysfunction

2016 ◽  
Vol 13 (3) ◽  
pp. 3-8
Author(s):  
Mariia Vladimirovna Matveeva ◽  
Julia Gennadevna Samoylova ◽  
Natalija Grigorevna Zhukova
Keyword(s):  
Cardiovascular Disease ◽  
Metabolic Syndrome ◽  
Neurological Disorders ◽  
Systematic Data ◽  
Obvious Association ◽  
Long Time ◽  
Leading Position ◽  
Biochemical Mechanisms ◽  
Per Se

Obesity takes epidemic proportions, encompassing different groups of society. In turn, cerebrovascular pathology holds a leading position in the spectrum of neurological disorders. Researchers indicate a role of obesity in the development of cognitive impairment. However, the cellular and biochemical mechanisms underlying that connection are still poorly understood. In addition, despite the obvious association of obesity with the deterioration of mental activity demonstrated in clinical trials for a long time it was unclear whether these disorders are caused by obesity per se or related conditions, such as metabolic syndrome, diabetes or cardiovascular disease. Currently there is scarse systematic data on a cause-effect relationships of these two pathologies.

scholarly journals Effect of Gamma-Oryzanol as Therapeutic Agent to Prevent Cardiorenal Metabolic Syndrome in Animals Submitted to High Sugar-Fat Diet

Nutrients ◽  
2017 ◽  
Vol 9 (12) ◽  
pp. 1299 ◽  
Author(s):  
Fabiane Francisqueti ◽  
Igor Minatel ◽  
Artur Ferron ◽  
Silméia Bazan ◽  
Vanessa Silva ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Therapeutic Agent ◽  
High Sugar ◽  
Gamma Oryzanol

scholarly journals THERAPEUTIC IMPORTANCE OF CURCUMIN WITH A SPECIAL EMPHASIS ON MDR CANCER CELLS AND THE FACTORS INFLUENCING PHARMACODYNAMICS.

2021 ◽  
pp. 429-441
Author(s):  
MUHASINA.K.M ◽  
Dhanabal S. Palaniswamy ◽  
Deepika.N.P ◽  
Divya jyothi Palati
Keyword(s):  
Cancer Cells ◽  
Neurological Disorders ◽  
Metabolic Disorders ◽  
Therapeutic Agent ◽  
Inflammatory Diseases ◽  
Curcuma Longa ◽  
Vascular Diseases ◽  
Immune Disorders ◽  
Pharmacological Activities ◽  
Cardio Vascular

Curcuma longa or turmeric is a plant that is used as a spice and as a phytoconstituent in many formulations from Vedic age. Curcuminoids are the most important Phyto constituents present in turmeric with various pharmacological activities. The present study reveals various pharmacological activities of curcumin with special emphasis on MDR cancer cells. The curcuminoids are the Phyto constituents showing potent activity against neurological disorders, cardio vascular diseases, auto immune disorders, Metabolic disorders, cancer, inflammatory diseases, Skin allergies and disorders. This review give emphasis on anticancer activity of curcumin and its possible mechanism of actions. Many studies revealing that various formulations and combination therapy of curcumin is increasing its bioavailability and there by effective against various diseases. This review is lighting to a treasure buried inside the soil a potential therapeutic agent without side effects.

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