Molecular and Endocrine Mechanisms Underlying the Stem Cell Theory of Aging

2013 ◽  
pp. 389-417
Author(s):  
Daniel L. Coutu ◽  
Jacques Galipeau
Keyword(s):  
Stem Cell ◽  
Cell Theory ◽  
Theory Of Aging

scholarly journals The Evolution of the Stem Cell Theory for Heart Failure

EBioMedicine ◽  
2015 ◽  
Vol 2 (12) ◽  
pp. 1871-1879 ◽  
Author(s):  
Jean-Sébastien Silvestre ◽  
Philippe Menasché
Keyword(s):  
Heart Failure ◽  
Stem Cell ◽  
Cell Theory

The chiaroscuro stem cell: a unified stem cell theory

Blood ◽  
2002 ◽  
Vol 100 (13) ◽  
pp. 4266-4271 ◽  
Author(s):  
Peter J. Quesenberry ◽  
Gerald A. Colvin ◽  
Jean-Francois Lambert
Keyword(s):  
Gene Expression ◽  
Cell Cycle ◽  
Stem Cell ◽  
Marrow Cell ◽  
Receptor Expression ◽  
Cell Theory ◽  
Surface Receptor ◽  
Stem Cell Hierarchy ◽  
External Stimuli ◽  
Existing Data

Hematopoiesis has been considered hierarchical in nature, but recent data suggest that the system is not hierarchical and is, in fact, quite functionally plastic. Existing data indicate that engraftment and progenitor phenotypes vary inversely with cell cycle transit and that gene expression also varies widely. These observations suggest that there is no progenitor/stem cell hierarchy, but rather a reversible continuum. This may, in turn, be dependent on shifting chromatin and gene expression with cell cycle transit. If the phenotype of these primitive marrow cells changes from engraftable stem cell to progenitor and back to engraftable stem cell with cycle transit, then this suggests that the identity of the engraftable stem cell may be partially masked in nonsynchronized marrow cell populations. A general model indicates a marrow cell that can continually change its surface receptor expression and thus responds to external stimuli differently at different points in the cell cycle.

scholarly journals Cancer and deregulation of stem cells pathways

2011 ◽  
Vol 2 (4) ◽  
pp. 199
Author(s):  
Filipe Correia Martins ◽  
Maria Filomena Botelho ◽  
António Manuel Cabrita ◽  
Maria Isabel Torgal ◽  
Carlos Freire De Oliveira
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Tumor Suppressor Genes ◽  
Tumor Development ◽  
Signaling Cascades ◽  
Cell Theory ◽  
Regulatory Pathways ◽  
Apoptosis Inhibition ◽  
Proliferation And Apoptosis ◽  
Control Tumor

Stem cells may have an important etiological role in cancer. Their classic regulatory pathways are deregulated in tumors, strengthening the stem cell theory of cancer. In this manuscript, we review Wnt, Notch and Hedhehog pathways, describing which of their factors may be responsible for the neoplastic development. Furthermore, we classify these elements as oncogenes or tumor suppressor genes, demonstrating their mutation implications in cancer. The activation of these pathways is associated with the expression of certain genes which maintain proliferation and apoptosis inhibition. Further work should be carried out in the future in order to control tumor development by controlling these signaling cascades.

Stem cell theory of colorectal cancer and its connection with molecularbiological data

2007 ◽  
Vol 148 (17) ◽  
pp. 779-785 ◽  
Author(s):  
Krisztina Hagymási ◽  
Béla Molnár ◽  
Ferenc Sipos ◽  
Orsolya Galamb ◽  
Zsolt Tulassay
Keyword(s):  
Colorectal Cancer ◽  
Stem Cell ◽  
Cell Theory ◽  
P16 Ink4a

A colorectalis rák a második leggyakoribb halálok hazánkban és a fejlett országokban is. A kórkép gyakori előfordulását az epithelsejtek gyors életciklusa, anyagcseréje, illetve a táplálkozási karcinogének közvetlen hatása magyarázza. A legújabb felfogás szerint a rák az őssejtek betegségének tekinthető. Ismereteink az utóbbi években jelentősen bővültek a emésztőrendszeri őssejtek elhelyezkedéséről (niche), sejtciklusukról, szabályozásukról (Notch, illetve Wnt/β-catenin jelrendszer) és markereikről (mathusashi-1, β-catenin). Az őssejtek és a daganatsejtek számos tulajdonságukban – önmegújító és proliferációs képességükben is – hasonlítanak egymáshoz. Újonnan merült fel a gyulladásos jelekre bevándorló csontvelő-eredetű őssejtek szerepe a daganatképződésben. A helyi vagy bevándorló őssejtek malignus átalakulásának okai mutációk (APC-, MMR-gének) vagy metiláció (CDKN2A, p16/INK4a, MGMT, MLH1) lehetnek. A dysplasiás sejtek terjedése még tisztázásra vár.

Abstract 2624: Possibility of prostate cancer prevention based on cancer stem cell theory

2016 ◽  
Author(s):  
Nobuya Shiozawa ◽  
Ryosuke Sugahara ◽  
Ayami Sato ◽  
Masako Ota ◽  
Tomohiro Yano
Keyword(s):  
Prostate Cancer ◽  
Stem Cell ◽  
Cancer Stem Cell ◽  
Cancer Prevention ◽  
Cell Theory ◽  
Prostate Cancer Prevention
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