Cr (VI) induces cell growth arrest through hydrogen peroxide-mediated reactions

2001 ◽  
pp. 77-83
Author(s):  
Zhuo Zhang ◽  
Stephen S. Leonard ◽  
Suwei Wang ◽  
Val Vallyathan ◽  
Vince Castranova ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Cell Growth ◽  
Growth Arrest ◽  
Cell Growth Arrest

Inducing cell growth arrest and apoptosis by silencing long non-coding RNA PCAT-1 in human bladder cancer

Tumor Biology ◽  
2015 ◽  
Vol 36 (10) ◽  
pp. 7685-7689 ◽  
Author(s):  
Li Liu ◽  
Yuchen Liu ◽  
Chengle Zhuang ◽  
Wen Xu ◽  
Xing Fu ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Cell Growth ◽  
Growth Arrest ◽  
Human Bladder Cancer ◽  
Human Bladder ◽  
Cell Growth Arrest ◽  
Non Coding Rna ◽  
Long Non Coding Rna

Lipid biomarkers of glioma cell growth arrest and cell death detected by 1 H magic angle spinning MRS

2012 ◽  
Vol 25 (11) ◽  
pp. 1253-1262 ◽  
Author(s):  
Ladan Mirbahai ◽  
Martin Wilson ◽  
Christopher S. Shaw ◽  
Carmel McConville ◽  
Roger D. G. Malcomson ◽  
...  
Keyword(s):  
Cell Death ◽  
Cell Growth ◽  
Glioma Cell ◽  
Growth Arrest ◽  
Magic Angle Spinning ◽  
Lipid Biomarkers ◽  
Magic Angle ◽  
Cell Growth Arrest ◽  
Angle Spinning

scholarly journals Prevention of Cell Growth by Suppression of Villin Expression in Lithocholic Acid-Stimulated HepG2 Cells

2018 ◽  
Vol 67 (2) ◽  
pp. 129-141 ◽  
Author(s):  
Munetaka Ozeki ◽  
Wulamujiang Aini ◽  
Aya Miyagawa-Hayashino ◽  
Keiji Tamaki
Keyword(s):  
Cell Growth ◽  
Hepg2 Cells ◽  
Lithocholic Acid ◽  
Morphological Changes ◽  
Growth Arrest ◽  
Pregnane X Receptor ◽  
Farnesoid X Receptor ◽  
Bile Canaliculi ◽  
Cell Growth Arrest ◽  
Depth Analysis

Summary Cholestasis is a condition wherein bile flow is interrupted and lithocholic acid is known to play a key role in causing severe liver injury. In this study, we performed in-depth analysis of the morphological changes in bile canaliculi and the biological role of villin in cholestasis using lithocholic acid-stimulated HepG2 human hepatocarcinoma cells. We confirmed disruption of the bile canaliculi in liver sections from a liver allograft patient with cholestasis. Lithocholic acid caused strong cytotoxicity in HepG2 cells, which was associated with abnormal morphology. Lithocholic acid reduced villin expression, which recovered in the presence of nuclear receptor agonists. Furthermore, villin mRNA expression increased following small interfering RNA (siRNA)-mediated knockdown of the nuclear farnesoid X receptor and pregnane X receptor. Villin knockdown using siRNA caused cell growth arrest in HepG2 cells. The effect of villin-knockdown on whole-genome expression in HepG2 cells was analyzed by DNA microarray. Our data suggest that lithocholic acid caused cell growth arrest by suppressing villin expression via farnesoid X receptor and pregnane X receptor in HepG2 cells.

Cell Growth Arrest by Nucleotides as a Tool for Improved Production of Biopharmaceuticals

2003 ◽  
pp. 77-81 ◽  
Author(s):  
A. V. Carvalhal ◽  
S. SÁ Santos ◽  
A. Coroadinha ◽  
I. Marcelino ◽  
M. J. T. Carrondo
Keyword(s):  
Cell Growth ◽  
Growth Arrest ◽  
Cell Growth Arrest

Mo1743 – Knock-Down of Granulin, a Novel Stat3-Interacting Protein, Hampers Stat3 Oncogenic Activity in Crc Cells Thus Promoting Cell Growth Arrest and Apoptosis

2019 ◽  
Vol 156 (6) ◽  
pp. S-829
Author(s):  
Fabio Cherubini ◽  
Federica Laudisi ◽  
Antonio Di Grazia ◽  
Vincenzo Dinallo ◽  
Davide Di Fusco ◽  
...  
Keyword(s):  
Cell Growth ◽  
Growth Arrest ◽  
Interacting Protein ◽  
Cell Growth Arrest ◽  
Knock Down ◽  
Oncogenic Activity
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