Disabled-2 Mediation of Retinoic Acid Cell Growth Arrest Signal in Breast Cancer

2002 ◽  
Author(s):  
Elizabeth R. Smith
Keyword(s):  
Breast Cancer ◽  
Retinoic Acid ◽  
Cell Growth ◽  
Growth Arrest ◽  
Cell Growth Arrest

scholarly journals ERp29 induces breast cancer cell growth arrest and survival through modulation of activation of p38 and upregulation of ER stress protein p58IPK

2011 ◽  
Vol 92 (2) ◽  
pp. 200-213 ◽  
Author(s):  
Danmei Gao ◽  
I Fon Bambang ◽  
Thomas C Putti ◽  
Yuan Kun Lee ◽  
Des R Richardson ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Growth ◽  
Er Stress ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Stress Protein ◽  
Growth Arrest ◽  
Cancer Cell Growth ◽  
Cell Growth Arrest ◽  
Breast Cancer Cell Growth

Retinoic acid causes cell growth arrest and an increase in p27 in F9 wild type but not in F9 retinoic acid receptor β2 knockout cells

2004 ◽  
Vol 294 (1) ◽  
pp. 290-300 ◽  
Author(s):  
Rong Li ◽  
Teresa N Faria ◽  
Manfred Boehm ◽  
Elizabeth G Nabel ◽  
Lorraine J Gudas
Keyword(s):  
Retinoic Acid ◽  
Cell Growth ◽  
Retinoic Acid Receptor ◽  
Growth Arrest ◽  
Wild Type ◽  
Cell Growth Arrest ◽  
Acid Receptor ◽  
Retinoic Acid Receptor Β2

scholarly journals Anti-Proliferative and Pro-Apoptotic Effects of Calligonum comosum (L’Her.) Methanolic Extract in Human Triple-Negative MDA-MB-231 Breast Cancer Cells

2020 ◽  
Vol 25 ◽  
pp. 2515690X2097839
Author(s):  
Zeyad Alehaideb ◽  
Saleh AlGhamdi ◽  
Wesam Bin Yahya ◽  
Hamad Al-Eidi ◽  
Mashael Alharbi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Growth ◽  
Cytochrome C ◽  
Cell Viability ◽  
Triple Negative ◽  
Methanolic Extract ◽  
Growth Arrest ◽  
Related Protein ◽  
Cell Growth Arrest ◽  
Apoptosis Related Protein

Triple-negative breast cancer (TNBC), the most aggressive subtype, does not respond to targeted therapy due to the lack of hormone receptors. There is an urgent need for alternative therapies, including natural product-based anti-cancer drugs, at lower cost. We investigated the impact of a Calligonum comosum L’Hér. methanolic extract (CcME) on the TNBC MDA-MB-231 cell line proliferation and related cell death mechanisms performing cell viability and cytotoxicity assays, flow cytometry to detect apoptosis and cell cycle analysis. The apoptosis-related protein array and cellular reactive oxygen species (ROS) assay were also carried out. We showed that the CcME inhibited the TNBC cell viability, in a dose-dependent manner, with low cytotoxic effects. The CcME-treated TNBC cells underwent apoptosis, associated with a concomitant increase of apoptosis-related protein expression, including cytochrome c, cleaved caspase-3, cyclin-dependent kinase inhibitor p21, and the anti-oxidant enzyme catalase, compared with the untreated cells. The CcME also enhanced the mitochondrial transition pore opening activity and induced G0/G1 cell growth arrest, which confirmed the cytochrome c release and the increase of the p21 expression detected in the CcME-treated TNBC cells. The CcME-treated TNBC cells resulted in intracellular ROS production, which, when blocked with a ROS scavenger, did not reduce the CcME-induced apoptosis. In conclusion, CcME exerts anti-proliferative effects against TNBC cells through the induction of apoptosis and cell growth arrest. In vivo studies are justified to verify the CcME anti-proliferative activities and to investigate any potential anti-metastatic activities of CcME against TNBC development and progression.

All-trans-retinoic acid induces cell growth arrest in a human medulloblastoma cell line

2007 ◽  
Vol 84 (3) ◽  
pp. 263-267 ◽  
Author(s):  
Qing Chang ◽  
Zhengshan Chen ◽  
Jiangfeng You ◽  
Michael A. McNutt ◽  
Ting Zhang ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Cell Growth ◽  
Cell Line ◽  
Growth Arrest ◽  
Cell Growth Arrest ◽  
Medulloblastoma Cell ◽  
Medulloblastoma Cell Line ◽  
Trans Retinoic Acid ◽  
All Trans Retinoic Acid ◽  
Human Medulloblastoma

scholarly journals Overexpression of PTEN Induces Cell Growth Arrest and Apoptosis in Human Breast Cancer ZR-75-1 Cells

2007 ◽  
Vol 39 (10) ◽  
pp. 745-750 ◽  
Author(s):  
Xiangyong LI ◽  
Guanping LIN ◽  
Binhua WU ◽  
Xin ZHOU ◽  
Keyuan ZHOU
Keyword(s):  
Breast Cancer ◽  
Cell Growth ◽  
Human Breast Cancer ◽  
Growth Arrest ◽  
Human Breast ◽  
Cell Growth Arrest
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