Vascular Endothelium: An Integrator of Pathophysiologic Stimuli in Cardiovascular Disease

1995 ◽  
pp. 105-107
Author(s):  
Michael A. Gimbrone
Keyword(s):  
Cardiovascular Disease ◽  
Vascular Endothelium

scholarly journals Homocysteine and vitamins in cardiovascular disease

1998 ◽  
Vol 44 (8) ◽  
pp. 1833-1843 ◽  
Author(s):  
Donald W Jacobsen
Keyword(s):  
Cardiovascular Disease ◽  
Folic Acid ◽  
Vascular Endothelium ◽  
Intervention Studies ◽  
Genetic Mutation ◽  
Plasma Homocysteine ◽  
Total Plasma ◽  
Homocysteine Concentration ◽  
Atherothrombotic Disease ◽  
Lines Of Evidence

Abstract On the basis of recent retrospective and prospective studies, it is now widely accepted that increased total plasma homocysteine is a risk factor for cardiovascular disease. Impaired enzyme function as a result of genetic mutation or deficiency of the essential B vitamins folic acid, B12, and B6 can lead to hyperhomocysteinemia. Oxidized forms of homocysteine account for 98–99% of total plasma homocysteine. Although there is uncertainty as to whether increased homocysteine is causal or merely a proxy for cardiovascular disease, several lines of evidence suggest that it may play a role in atherothrombotic disease. Homocysteine appears to alter the anticoagulant properties of endothelial cells to a procoagulant phenotype. Mildly increased homocysteine causes dysfunction of the vascular endothelium. Folic acid effectively lowers homocysteine concentration in the plasma. Intervention studies are urgently needed to determine if lowering homocysteine is effective in decreasing the morbidity and mortality of cardiovascular disease.

Granulocyte: Friend and Foe

Physiology ◽  
1988 ◽  
Vol 3 (4) ◽  
pp. 144-147
Author(s):  
W. Schmid-Schonbein G,
Keyword(s):  
Cardiovascular Disease ◽  
Wide Class ◽  
Vascular Endothelium ◽  
Cardiovascular Complications ◽  
Microvascular Perfusion ◽  
Red Cells

Circulating granulocytes play an important role in microvascular perfusion and organ pathology. Compared with red cells, granulocytes are large, stiff cells that can adhere strongly to the vascular endothelium. This may cause accumulation of granulocytes in the microcirculation and obstruct capillaries and cause cardiovascular complications. The analysis of granulocyte kinetics in the circulation has helped us better understand the etiology of a wide class of cardiovascular disease.

Vascular endothelium summary statement II: Cardiovascular disease prevention and control

2007 ◽  
Vol 46 (5) ◽  
pp. 318-320 ◽  
Author(s):  
George A. Mensah ◽  
Una S. Ryan ◽  
W. Craig Hooper ◽  
Michael M. Engelgau ◽  
Allan D. Callow ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Disease Prevention ◽  
Vascular Endothelium ◽  
Prevention And Control ◽  
Cardiovascular Disease Prevention ◽  
Summary Statement ◽  
And Control

Vascular Endothelium Dysfunction in REM Sleep Deprivation: Prelude to Cardiovascular Disease

2019 ◽  
Vol 297 ◽  
pp. 27
Author(s):  
W.A.N. Wan Ahmad ◽  
L. Noordin ◽  
T.F.A. Tengku Adnan ◽  
S. Safuan ◽  
C.B. Ab Aziz
Keyword(s):  
Cardiovascular Disease ◽  
Sleep Deprivation ◽  
Rem Sleep ◽  
Vascular Endothelium ◽  
Rem Sleep Deprivation ◽  
Endothelium Dysfunction

Cardiovascular Disease: Effects Upon Cognition and Communication

ASHA Leader ◽  
2006 ◽  
Vol 11 (7) ◽  
pp. 10-23 ◽  
Author(s):  
Laura Murray
Keyword(s):  
Cardiovascular Disease
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