Molecular-Genetic Systems Controlling Morphogenesis and Differentiation in Multicellular Organisms. Molecular Structure of Chromosomes of the Cell Nucleus and Structural and Biochemical Features of Genetic and Functional Differentiation of Chromosomes

1970 ◽  
pp. 127-182
Author(s):  
Zhores A. Medvedev
Keyword(s):  
Molecular Structure ◽  
Cell Nucleus ◽  
Molecular Genetic ◽  
Functional Differentiation ◽  
Genetic Systems ◽  
Multicellular Organisms ◽  
Biochemical Features

MATHEMATICAL AND COMPUTER MODELLING CONTROL MECHANISMS OF HIERARCHICAL MOLECULAR-GENETIC SYSTEMS

BIOMAT 2009 ◽  
2010 ◽  
Author(s):  
H. B. NABIEVICH ◽  
S. MAHRUY ◽  
H. M. BAHROMOVNA ◽  
A. B. RAHIMBERDIEVICH
Keyword(s):  
Computer Modelling ◽  
Molecular Genetic ◽  
Control Mechanisms ◽  
Genetic Systems

Molecular genetic systems to study the role of poly(ADP-ribosyl)ation in the cellular response to DNA damage

Biochimie ◽  
1995 ◽  
Vol 77 (6) ◽  
pp. 450-455 ◽  
Author(s):  
J.H. Küpper ◽  
L. van Gool ◽  
A. Bürkle
Keyword(s):  
Dna Damage ◽  
Cellular Response ◽  
Molecular Genetic ◽  
Genetic Systems

Advances in molecular genetic systems in malaria

2015 ◽  
Vol 13 (6) ◽  
pp. 373-387 ◽  
Author(s):  
Tania F. de Koning-Ward ◽  
Paul R. Gilson ◽  
Brendan S. Crabb
Keyword(s):  
Molecular Genetic ◽  
Genetic Systems

Mitochondrial Neurogastrointestinal Encephalomyopathy (MNGIE): Biochemical Features and Therapeutic Approaches

2007 ◽  
Vol 27 (1-3) ◽  
pp. 151-163 ◽  
Author(s):  
M. C. Lara ◽  
M. L. Valentino ◽  
J. Torres-Torronteras ◽  
M. Hirano ◽  
R. Martí
Keyword(s):  
Molecular Genetic ◽  
In Vivo Studies ◽  
Gene Encoding ◽  
Mitochondrial Neurogastrointestinal Encephalomyopathy ◽  
Mtdna Replication ◽  
Biochemical Features

Over the last 15 years, important research has expanded our knowledge of the clinical, molecular genetic, and biochemical features of mitochondrial neurogastrointestinal encephalomyopathy (MNGIE). The characterization of mitochondrial involvement in this disorder and the seminal determination of its genetic cause, have opened new possibilities for more detailed and deeper studies on the pathomechanisms in this progressive and fatal disease. It has been established that MNGIE is caused by mutations in the gene encoding thymidine phosphorylase (TP), which lead to absolute or nearly complete loss of its catalytic activity, producing systemic accumulations of its substrates, thymidine (dThd) and deoxyuridine (dUrd). Findings obtained from in vitro and in vivo studies indicate that the biochemical imbalances specifically impair mitochondrial DNA (mtDNA) replication, repair, or both leading to mitochondrial dysfunction. We have proposed that therapy for MNGIE should be aimed at reducing the concentrations of these toxic nucleosides to normal or nearly normal levels. The first treatment, allogeneic stem-cell transplantation (alloSCT) reported in 2006, produced a nearly full biochemical correction of the dThd and dUrd imbalances in blood. Clinical follow-up of this and other patients receiving alloSCT is necessary to determine whether this and other therapies based on a permanent restoration of TP will be effective treatment for MNGIE.

scholarly journals The structure and function of the ATP-sensitive K+ channel in insulin-secreting pancreatic beta-cells

1999 ◽  
Vol 22 (2) ◽  
pp. 113-123 ◽  
Author(s):  
T Miki ◽  
K Nagashima ◽  
S Seino
Keyword(s):  
Molecular Structure ◽  
Insulin Secretion ◽  
Beta Cell ◽  
Beta Cells ◽  
Katp Channel ◽  
Pancreatic Beta Cells ◽  
Pancreatic Beta Cell ◽  
Molecular Genetic ◽  
Katp Channels ◽  
K Channel

ATP-sensitive K+ channels (KATP channels) play important roles in many cellular functions by coupling cell metabolism to electrical activity. The KATP channels in pancreatic beta-cells are thought to be critical in the regulation of glucose-induced and sulfonylurea-induced insulin secretion. Until recently, however, the molecular structure of the KATP channel was not known. Cloning members of the novel inwardly rectifying K+ channel subfamily Kir6.0 (Kir6.1 and Kir6.2) and the sulfonylurea receptors (SUR1 and SUR2) has clarified the molecular structure of KATP channels. The pancreatic beta-cell KATP channel comprises two subunits: a Kir6.2 subunit and an SUR1 subunit. Molecular biological and molecular genetic studies have provided insights into the physiological and pathophysiological roles of the pancreatic beta-cell KATP channel in insulin secretion.

scholarly journals A genetic program mediates cold-warming response and promotes stress-induced phenoptosis in C. elegans

eLife ◽  
2018 ◽  
Vol 7 ◽  
Author(s):  
Wei Jiang ◽  
Yuehua Wei ◽  
Yong Long ◽  
Arthur Owen ◽  
Bingying Wang ◽  
...  
Keyword(s):  
Wild Population ◽  
Molecular Genetic ◽  
Genetic Program ◽  
Transcriptional Program ◽  
Uncharacterized Protein ◽  
C Elegans ◽  
Enhanced Resistance ◽  
Hypothermic Stress ◽  
Multicellular Organisms ◽  
Encoding Genes

How multicellular organisms respond to and are impacted by severe hypothermic stress is largely unknown. From C. elegans screens for mutants abnormally responding to cold-warming stimuli, we identify a molecular genetic pathway comprising ISY-1, a conserved uncharacterized protein, and ZIP-10, a bZIP-type transcription factor. ISY-1 gatekeeps the ZIP-10 transcriptional program by regulating the microRNA mir-60. Downstream of ISY-1 and mir-60, zip-10 levels rapidly and specifically increase upon transient cold-warming exposure. Prolonged zip-10 up-regulation induces several protease-encoding genes and promotes stress-induced organismic death, or phenoptosis, of C. elegans. zip-10 deficiency confers enhanced resistance to prolonged cold-warming stress, more prominently in adults than larvae. We conclude that the ZIP-10 genetic program mediates cold-warming response and may have evolved to promote wild-population kin selection under resource-limiting and thermal stress conditions.

Molecular-genetic systems of development: Functional dynamics and molecular evolution

2008 ◽  
Vol 73 (2) ◽  
pp. 219-230 ◽  
Author(s):  
K. V. Gunbin ◽  
V. V. Suslov ◽  
N. A. Kolchanov
Keyword(s):  
Molecular Evolution ◽  
Molecular Genetic ◽  
Functional Dynamics ◽  
Genetic Systems
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