Insulin, Glucose, and Glucagon are Potential Modulators of Thyroid Hormone Action Through Brown Adipose Tissue 5′-Deiodinase in Rats

1986 ◽  
pp. 767-771
Author(s):  
J. Enrique Silva ◽  
P. Reed Larsen
Keyword(s):  
Adipose Tissue ◽  
Thyroid Hormone ◽  
Brown Adipose Tissue ◽  
Hormone Action ◽  
Thyroid Hormone Action ◽  
Brown Adipose

Adipose tissue and skeletal muscle expression of genes associated with thyroid hormone action in obesity and insulin resistance

Thyroid ◽  
2021 ◽  
Author(s):  
Marek Strączkowski ◽  
Agnieszka Nikołajuk ◽  
Magdalena Stefanowicz ◽  
Natalia Matulewicz ◽  
José Manuel Fernández-Real ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Skeletal Muscle ◽  
Adipose Tissue ◽  
Thyroid Hormone ◽  
Hormone Action ◽  
Thyroid Hormone Action ◽  
Expression Of Genes

scholarly journals Correction: Thyroid Hormone Activates Brown Adipose Tissue and Increases Non-Shivering Thermogenesis—A Cohort Study in a Group of Thyroid Carcinoma Patients

PLoS ONE ◽  
2018 ◽  
Vol 13 (12) ◽  
pp. e0209225
Author(s):  
Evie P. M. Broeders ◽  
Guy H. E. J. Vijgen ◽  
Bas Havekes ◽  
Nicole D. Bouvy ◽  
Felix M. Mottaghy ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Cohort Study ◽  
Thyroid Hormone ◽  
Thyroid Carcinoma ◽  
Brown Adipose Tissue ◽  
Brown Adipose ◽  
Shivering Thermogenesis

Regulation of brown adipose tissue lipogenesis by thyroid hormone and the sympathetic nervous system

1993 ◽  
Vol 265 (2) ◽  
pp. E252-E258 ◽  
Author(s):  
W. J. Yeh ◽  
P. Leahy ◽  
H. C. Freake
Keyword(s):  
Nervous System ◽  
Adipose Tissue ◽  
Fatty Acid ◽  
Thyroid Hormone ◽  
Sympathetic Nervous System ◽  
Brown Adipose Tissue ◽  
Fatty Acid Synthase ◽  
Northern Analysis ◽  
Brown Adipose ◽  
Sympathetic Nervous

Thyroid hormone regulates lipogenesis differently in rat liver and brown adipose tissue (BAT). In the hypothyroid state, lipogenesis is suppressed in liver but enhanced in BAT. Here we investigated the mechanisms underlying increased lipogenesis in hypothyroid BAT. Housing the animals at 28 degrees C decreased lipogenesis in hypothyroid BAT to euthyroid levels. Denervation resulted in a 90% reduction in lipogenesis in hypothyroid BAT such that levels were lower than in euthyroid tissue. Thyroid hormone treatment of hypothyroid rats stimulated fatty acid synthesis in denervated BAT, as in liver, but decreased it in intact BAT. Steady-state levels of mRNA encoding acetyl-CoA carboxylase, fatty-acid synthase, and spor 14 were measured in similar animals by Northern analysis. The expression of these mRNAs mirrored the lipogenic data, showing that both thyroid hormone and the sympathetic nervous system work at a pretranslational level in this tissue. These data suggest that the increased BAT lipogenesis found with hypothyroidism is mediated by the sympathetic nervous system to counter the reduction in metabolic rate in these animals.

Inhibition of Type 1 Iodothyronine Deiodinase by Bisphenol A

2019 ◽  
Vol 51 (10) ◽  
pp. 671-677 ◽  
Author(s):  
Maurício Martins da Silva ◽  
Carlos Frederico Lima Gonçalves ◽  
Leandro Miranda-Alves ◽  
Rodrigo Soares Fortunato ◽  
Denise P. Carvalho ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Thyroid Hormone ◽  
Bisphenol A ◽  
Brown Adipose Tissue ◽  
Tissue Type ◽  
Deiodinase Activity ◽  
Brown Adipose

AbstractPlastics are ubiquitously present in our daily life and some components of plastics are endocrine-disrupting chemicals, such as bisphenol A and phthalates. Herein, we aimed to evaluate the effect of plastic endocrine disruptors on type 1 and type 2 deiodinase activities, enzymes responsible for the conversion of the pro-hormone T4 into the biologically active thyroid hormone T3, both in vitro and in vivo. Initially, we incubated rat liver type 1 deiodinase and brown adipose tissue type 2 deiodinase samples with 0.5 mM of the plasticizers, and the deiodinase activity was measured. Among them, only BPA was capable to inhibit both type 1 and type 2 deiodinases. Then, adult male Wistar rats were treated orally with bisphenol A (40 mg/kg b.w.) for 15 days and hepatic type 1 deiodinase and brown adipose tissue type 2 deiodinase activities and serum thyroid hormone concentrations were measured. In vivo bisphenol A treatment significantly reduced hepatic type 1 deiodinase activity but did not affect brown adipose tissue type 2 deiodinase activity. Serum T4 levels were higher in bisphenol A group, while T3 remained unchanged. T3/T4 ratio was decreased in rats treated with bisphenol A, reinforcing the idea that peripheral metabolism of thyroid hormone was affected by bisphenol A exposure. Therefore, our results suggest that bisphenol A can affect the metabolism of thyroid hormone thus disrupting thyroid signaling.

Brown Adipose Tissue (BAT) detection by 18F-FDG PET and thyroid hormone level(s)—a systematic review

Endocrine ◽  
2018 ◽  
Vol 62 (2) ◽  
pp. 496-500 ◽  
Author(s):  
Prasanna Santhanam ◽  
Rexford S Ahima ◽  
Jennifer S Mammen ◽  
Luca Giovanella ◽  
Giorgio Treglia
Keyword(s):  
Systematic Review ◽  
Adipose Tissue ◽  
Thyroid Hormone ◽  
Brown Adipose Tissue ◽  
Fdg Pet ◽  
Hormone Level ◽  
Thyroid Hormone Level ◽  
Brown Adipose ◽  
18F Fdg ◽  
Bat Detection

Selenium and iodine deficiencies: effects on brain and brown adipose tissue selenoenzyme activity and expression

1997 ◽  
Vol 155 (2) ◽  
pp. 255-263 ◽  
Author(s):  
JH Mitchell ◽  
F Nicol ◽  
GJ Beckett ◽  
Keyword(s):  
Adipose Tissue ◽  
Thyroid Hormone ◽  
Glutathione Peroxidase ◽  
Brown Adipose Tissue ◽  
Iodine Deficiency ◽  
Uncoupling Protein ◽  
Compensatory Mechanisms ◽  
Iodothyronine Deiodinase ◽  
Brown Adipose ◽  
The Brain

Adequate dietary iodine supplies and thyroid hormones are needed for the development of the central nervous system (CNS) and brown adipose tissue (BAT) function. Decreases in plasma thyroxine (T4) concentrations may increase the requirement for the selenoenzymes types I and II iodothyronine deiodinase (ID-I and ID-II) in the brain and ID-II in BAT to protect against any fall in intracellular 3,3',5 tri-iodothyronine (T3) concentrations in these organs. We have therefore investigated selenoenzyme activity and expression and some developmental markers in brain and BAT of second generation selenium- and iodine-deficient rats. Despite substantial alterations in plasma thyroid hormone concentrations and thyroidal and hepatic selenoprotein expression in selenium and iodine deficiencies, ID-I, cytosolic glutathione peroxidase (cGSHPx) and phospholipid hydroperoxide glutathione peroxidase (phGSHPx) activities and expression remained relatively constant in most brain regions studied. Additionally, brain and pituitary ID-II activities were increased in iodine deficiency regardless of selenium status. This can help maintain tissue T3 concentrations in hypothyroidism. Consistent with this, no significant effects of iodine or selenium deficiency on the development of the brain were observed, as assessed by the activities of marker enzymes. In contrast, BAT from selenium- and iodine deficient rats had impaired thyroid hormone metabolism and less uncoupling protein than in tissue from selenium- and iodine-supplemented animals. Thus, the effects of selenium and iodine deficiency on the brain are limited due to the activation of the compensatory mechanisms but these mechanisms are less effective in BAT.

scholarly journals Variable Cold-Induced Brown Adipose Tissue Response to Thyroid Hormone Status

Thyroid ◽  
2017 ◽  
Vol 27 (1) ◽  
pp. 1-10 ◽  
Author(s):  
Alina Gavrila ◽  
Per-Olof Hasselgren ◽  
Allison Glasgow ◽  
Ashley N. Doyle ◽  
Alice J. Lee ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Thyroid Hormone ◽  
Brown Adipose Tissue ◽  
Tissue Response ◽  
Brown Adipose ◽  
Hormone Status
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