α-Toxin Permeabilization of Rat Mesenteric Small Arteries and Effects of Stretch

1994 ◽  
pp. 23-29 ◽  
Author(s):  
Peter E. Jensen
Keyword(s):  
Small Arteries

scholarly journals Cerebral Small Vessel Disease

2020 ◽  
Vol 21 (24) ◽  
pp. 9729
Author(s):  
Jakub Litak ◽  
Marek Mazurek ◽  
Bartłomiej Kulesza ◽  
Paweł Szmygin ◽  
Joanna Litak ◽  
...  
Keyword(s):  
Small Vessel Disease ◽  
Current Knowledge ◽  
Cerebral Small Vessel Disease ◽  
Cerebral Vessels ◽  
Small Vessel ◽  
Epithelial Layer ◽  
Small Arteries ◽  
Vessel Disease ◽  
The Impact ◽  
Cerebral Small Vessel Diseases

Cerebral small vessel disease (CSVD) represents a cluster of various vascular disorders with different pathological backgrounds. The advanced vasculature net of cerebral vessels, including small arteries, capillaries, arterioles and venules, is usually affected. Processes of oxidation underlie the pathology of CSVD, promoting the degenerative status of the epithelial layer. There are several classifications of cerebral small vessel diseases; some of them include diseases such as Binswanger’s disease, leukoaraiosis, cerebral microbleeds (CMBs) and lacunar strokes. This paper presents the characteristics of CSVD and the impact of the current knowledge of this topic on the diagnosis and treatment of patients.

scholarly journals Influence of pressure alterations on tone and vasomotion of isolated mesenteric small arteries of the rat.

1991 ◽  
Vol 436 (1) ◽  
pp. 371-383 ◽  
Author(s):  
E VanBavel ◽  
M J Giezeman ◽  
T Mooij ◽  
J A Spaan
Keyword(s):  
Small Arteries

scholarly journals The immunohistochemical presence and distribution of ghrelin, apelin and their receptors in dog ovaries

2017 ◽  
Vol 8 (1) ◽  
Author(s):  
Carolina Pirino ◽  
Margherita Maranesi ◽  
Angela Polisca ◽  
Alessandro Troisi ◽  
Cecilia Dall'Aglio
Keyword(s):  
Connective Tissue ◽  
Infectious Diseases ◽  
Positive Reaction ◽  
Corpora Lutea ◽  
Small Arteries ◽  
Luteal Cells ◽  
Peripheral Organs ◽  
Immunohistochemical Techniques

The activity of ghrelin, apelin and their receptors has been correlated to the control of some infectious diseases, besides the hypothesis of their role in the control of some peripheral organs, among which ovaries. The aim of the present work was to highlight the presence and distribution of ghrelin, apelin and cognate receptors in the ovaries of pregnant bitches, by means of immunohistochemical techniques. Apelin, its receptor and the receptor of ghrelin were highlighted in the corpora lutea, with a particular localization in the cytoplasm of some luteal cells. Instead, a positive reaction for ghrelin was evident in the walls of small arteries in the connective tissue. These results allowed us to hypothesize that these molecules intervene in the control of ovaries in pregnant bitches, suggesting autocrine/paracrine mechanisms of regulation.

scholarly journals Vascular Matrix Metalloproteinase-9 Mediates the Inhibition of Myogenic Reactivity in Small Arteries Isolated from Rats after Short-Term Administration of Relaxin

Endocrinology ◽  
2007 ◽  
Vol 148 (1) ◽  
pp. 189-197 ◽  
Author(s):  
Arundhathi Jeyabalan ◽  
Jacqueline Novak ◽  
Ketah D. Doty ◽  
Julianna Matthews ◽  
Michelle C. Fisher ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Matrix Metalloproteinase 9 ◽  
Short Term ◽  
Small Arteries ◽  
Term Administration ◽  
Metalloproteinase 9

scholarly journals The Na,K-ATPase-Dependent Src Kinase Signaling Changes with Mesenteric Artery Diameter

2018 ◽  
Vol 19 (9) ◽  
pp. 2489 ◽  
Author(s):  
Lin Zhang ◽  
Christian Aalkjaer ◽  
Vladimir Matchkov
Keyword(s):  
Smooth Muscle ◽  
Binding Sites ◽  
Isometric Force ◽  
Src Kinase ◽  
Ouabain Binding ◽  
Arterial Diameter ◽  
Small Arteries ◽  
Functional Changes ◽  
High Affinity ◽  
Different Diameters

Inhibition of the Na,K-ATPase by ouabain potentiates vascular tone and agonist-induced contraction. These effects of ouabain varies between different reports. In this study, we assessed whether the pro-contractile effect of ouabain changes with arterial diameter and the molecular mechanism behind it. Rat mesenteric small arteries of different diameters (150–350 µm) were studied for noradrenaline-induced changes of isometric force and intracellular Ca2+ in smooth muscle cells. These functional changes were correlated to total Src kinase and Src phosphorylation assessed immunohistochemically. High-affinity ouabain-binding sites were semi-quantified with fluorescent ouabain. We found that potentiation of noradrenaline-sensitivity by ouabain correlates positively with an increase in arterial diameter. This was not due to differences in intracellular Ca2+ responses but due to sensitization of smooth muscle cell contractile machinery to Ca2+. This was associated with ouabain-induced Src activation, which increases with increasing arterial diameter. Total Src expression was similar in arteries of different diameters but the density of high-affinity ouabain binding sites increased with increasing arterial diameters. We suggested that ouabain binding induces more Src kinase activity in mesenteric small arteries with larger diameter leading to enhanced sensitization of the contractile machinery to Ca2+.

Evidence for a functional calcium-sensing receptor that modulates myogenic tone in rat subcutaneous small arteries

2005 ◽  
Vol 288 (4) ◽  
pp. H1756-H1762 ◽  
Author(s):  
Jacqueline Ohanian ◽  
Kelly M. Gatfield ◽  
Donald T. Ward ◽  
Vasken Ohanian
Keyword(s):  
Vascular Tissue ◽  
Immunoblot Analysis ◽  
Negative Regulator ◽  
Intraluminal Pressure ◽  
Myogenic Tone ◽  
Internal Diameter ◽  
Calcium Sensing Receptor ◽  
Small Arteries ◽  
Calcium Sensing

Myogenic tone of small arteries is dependent on the presence of extracellular calcium ([Formula: see text]), and, recently, a receptor that senses changes in Ca2+, the calcium-sensing receptor (CaR), has been detected in vascular tissue. We investigated whether the CaR is involved in the regulation of myogenic tone in rat subcutaneous small arteries. Immunoblot analysis using a monoclonal antibody against the CaR demonstrated its presence in rat subcutaneous arteries. To determine whether the CaR was functionally active, segments of artery (<250 μm internal diameter) mounted in a pressure myograph with an intraluminal pressure of 70 mmHg were studied after the development of myogenic tone. Increasing [Formula: see text] concentration ([Ca2+]o) cumulatively from 0.5 to 10 mM induced an initial constriction (0.5–2 mM) followed by dilation (42 ± 5% loss of tone). The dose-dependent dilation was mimicked by other known CaR agonists including magnesium (1–10 mM) and the aminoglycosides neomycin (0.003–10 mM) and kanamycin (0.003–3 mM). PKC activation with the phorbol ester phorbol-12,13-dibutyrate (20nM) inhibited the dilation induced by high [Ca2+]o or neomycin, whereas inhibition of PKC with GF109203X (10 μM) increased the responses to [Formula: see text] or neomycin, consistent with the role of PKC as a negative regulator of the CaR. We conclude that rat subcutaneous arteries express a functionally active CaR that may be involved in the modulation of myogenic tone and hence the regulation of peripheral vascular resistance.

Some pharmacological and elastic characteristics of isolated subcutaneous small arteries from patients with essential hypertension

1996 ◽  
Vol 14 (8) ◽  
pp. 993???998 ◽  
Author(s):  
Niels K. Thybo ◽  
Michael J. Mulvany ◽  
Birthe Jastrup ◽  
Henrik Nielsen ◽  
Christian Aalkj??r
Keyword(s):  
Essential Hypertension ◽  
Small Arteries ◽  
Elastic Characteristics
Sign in / Sign up

Export Citation Format

Share Document