Relationships Between Intra- Or Interindividual Variability and Biological Covariates: Application to Zidovudine Pharmacokinetics

1991 ◽  
pp. 119-128 ◽  
Author(s):  
France Mentré ◽  
Alain Mallet
Keyword(s):  
Interindividual Variability

The Limits of Ego Depletion

2019 ◽  
Vol 50 (5-6) ◽  
pp. 292-304 ◽  
Author(s):  
Mario Wenzel ◽  
Marina Lind ◽  
Zarah Rowland ◽  
Daniela Zahn ◽  
Thomas Kubiak
Keyword(s):  
Research Agenda ◽  
Statistical Power ◽  
Interindividual Variability ◽  
Ego Depletion ◽  
Crossover Design ◽  
Effect Sizes ◽  
Future Research ◽  
Future Research Agenda ◽  
Depletion Effect ◽  
Within Subjects

Abstract. Evidence on the existence of the ego depletion phenomena as well as the size of the effects and potential moderators and mediators are ambiguous. Building on a crossover design that enables superior statistical power within a single study, we investigated the robustness of the ego depletion effect between and within subjects and moderating and mediating influences of the ego depletion manipulation checks. Our results, based on a sample of 187 participants, demonstrated that (a) the between- and within-subject ego depletion effects only had negligible effect sizes and that there was (b) large interindividual variability that (c) could not be explained by differences in ego depletion manipulation checks. We discuss the implications of these results and outline a future research agenda.

Platelet monitoring for PCI

2009 ◽  
Vol 29 (04) ◽  
pp. 376-380 ◽  
Author(s):  
D. Capodanno ◽  
D. J. Angiolillo
Keyword(s):  
Interindividual Variability ◽  
State Of The Art ◽  
Coronary Intervention ◽  
Functional Tests ◽  
Treatment Regimens ◽  
Advantages And Disadvantages ◽  
Coronary Syndrome ◽  
Combined Use ◽  
Increased Risk ◽  
Percutaneous Coronary

SummaryDespite the clinical benefit associated with the combined use of aspirin and clopidogrel in patients with acute coronary syndrome or those undergoing percutaneous coronary intervention, a considerable interindividual variability in response to these drugs have been consistently reported. There is a growing interest on applying platelet functional tests with the goal of identifying patients at increased risk of recurrent ischaemic events and potentially tailoring antiplatelet treatment regimens.This manuscript will review the state of the art on the most commonly available platelet functional tests, describing their advantages and disadvantages and exploring their applicability in clinical practice.

scholarly journals Contribution of plant food bioactives in promoting health effects of plant foods: why look at interindividual variability?

2019 ◽  
Vol 58 (S2) ◽  
pp. 13-19 ◽  
Author(s):  
Christine Morand ◽  
Francisco A. Tomás-Barberán
Keyword(s):  
Health Effects ◽  
Interindividual Variability ◽  
Food Sources ◽  
Cardiometabolic Health ◽  
Plant Food ◽  
Health It ◽  
Plant Foods ◽  
Nutritional Needs ◽  
Main Determinants ◽  
Actual Contribution

Abstract Purpose Research has identified plant-based diets as the most protective for our health; it is now essential to focus on good food associations and the beneficial constituents in plant foods. From a growing body of evidence, some categories of food phytochemicals are increasingly considered to play a crucial role in the cardiometabolic health effects associated with plant food consumption. However, the heterogeneity in responsiveness to plant food bioactive intake that is frequently observed in clinical trials can hinder the identification of the effects of these compounds in specific subpopulations and likely lead to underestimating their actual contribution to the health effects of their food sources. Results The magnitude and the main factors responsible for this between-subject variation in response to the consumption of the major families of food phytochemicals have been poorly documented so far. Thus, research efforts in this area must be developed. More importantly, capturing the interindividual variability in response to plant food bioactive intake, together with identifying the main determinants involved, is a crucial step that will enable the development and production of plant food products, thereby satisfying the nutritional needs and conferring benefits to different categories of populations. Conclusion The development of a science-based personalised nutrition approach focusing on plant foods rich in specific bioactive compounds could contribute to alleviating the dramatic burden of metabolic and cardiovascular diseases.

Influence of Interindividual Variability of Aldose Reductase Protein Content on Polyol-Pathway Metabolites and Redox State in Erythrocytes in Diabetic Patients

Diabetes Care ◽  
1998 ◽  
Vol 21 (6) ◽  
pp. 1014-1018 ◽  
Author(s):  
Y. Hamada ◽  
C. Nishimura ◽  
N. Koh ◽  
F. Sakakibara ◽  
J. Nakamura ◽  
...  
Keyword(s):  
Protein Content ◽  
Aldose Reductase ◽  
Redox State ◽  
Interindividual Variability ◽  
Polyol Pathway ◽  
Diabetic Patients

Multifinality, equifinality, and fanning: Developmental concepts and statistical implications

2021 ◽  
pp. 016502542110204
Author(s):  
Ben Hinnant ◽  
John Schulenberg ◽  
Justin Jager
Keyword(s):  
Interindividual Variability ◽  
Growth Models ◽  
Practical Importance ◽  
Simulated Data ◽  
Developmental Changes ◽  
Effect Sizes ◽  
Over Time ◽  
Developmental Window

Multifinality, equifinality, and fanning are important developmental concepts that emphasize understanding interindividual variability in trajectories over time. However, each concept implies that there are points in a developmental window where interindividual variability is more limited. We illustrate the multifinality concept under manipulations of variance in starting points, using both normal and zero-inflated simulated data. Results indicate that standardized estimates and effect sizes are inflated when predicting components of growth models with limited interindividual variance, which could lead to overinterpretation of the practical importance of findings. Conceptual implications are considered and recommendations are provided for evaluating developmental changes in common situations that researchers may encounter.

scholarly journals Interindividual Variability and Intra-Individual Reproducibility of Glycemic Index Values for Commercial White Bread

Diabetes Care ◽  
2007 ◽  
Vol 30 (6) ◽  
pp. 1412-1417 ◽  
Author(s):  
S. Vega-Lopez ◽  
L. M. Ausman ◽  
J. L. Griffith ◽  
A. H. Lichtenstein
Keyword(s):  
Glycemic Index ◽  
Interindividual Variability ◽  
White Bread
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