Estimating Survival Probabilities from Mark-Re-Encounter Data

2014 ◽  
pp. 147-158
Author(s):  
K. B. Newman ◽  
S. T. Buckland ◽  
B. J. T. Morgan ◽  
R. King ◽  
D. L. Borchers ◽  
...  
Keyword(s):  
Survival Probabilities

scholarly journals SurvCNN: A Discrete Time-to-Event Cancer Survival Estimation Framework Using Image Representations of Omics Data

Cancers ◽  
2021 ◽  
Vol 13 (13) ◽  
pp. 3106
Author(s):  
Yogesh Kalakoti ◽  
Shashank Yadav ◽  
Durai Sundar
Keyword(s):  
Discrete Time ◽  
Cancer Survival ◽  
Performance Metrics ◽  
Downstream Processing ◽  
Cancer Prognosis ◽  
Precision Oncology ◽  
Omics Data ◽  
Time Model ◽  
Survival Probabilities ◽  
Image Representations

The utility of multi-omics in personalized therapy and cancer survival analysis has been debated and demonstrated extensively in the recent past. Most of the current methods still suffer from data constraints such as high-dimensionality, unexplained interdependence, and subpar integration methods. Here, we propose SurvCNN, an alternative approach to process multi-omics data with robust computer vision architectures, to predict cancer prognosis for Lung Adenocarcinoma patients. Numerical multi-omics data were transformed into their image representations and fed into a Convolutional Neural network with a discrete-time model to predict survival probabilities. The framework also dichotomized patients into risk subgroups based on their survival probabilities over time. SurvCNN was evaluated on multiple performance metrics and outperformed existing methods with a high degree of confidence. Moreover, comprehensive insights into the relative performance of various combinations of omics datasets were probed. Critical biological processes, pathways and cell types identified from downstream processing of differentially expressed genes suggested that the framework could elucidate elements detrimental to a patient’s survival. Such integrative models with high predictive power would have a significant impact and utility in precision oncology.

Radiation Therapy for Stage I Primary Orbital Non-Hodgkin's Lymphomas

1997 ◽  
Vol 83 (5) ◽  
pp. 822-825 ◽  
Author(s):  
Haldun Şükrü Erkal ◽  
Meltem Serin ◽  
Serpil Dizbay Sak ◽  
Ahmet Çakmak
Keyword(s):  
Radiation Therapy ◽  
Combination Chemotherapy ◽  
Disease Free Survival ◽  
Stage I ◽  
Entire Group ◽  
Low Grade ◽  
Intermediate Grade ◽  
Chop Regimen ◽  
Survival Probabilities ◽  
Hodgkin's Lymphomas

Aims and Background The orbit is an uncommon primary site for non-Hodgkin's lymphomas (NHL), and it accounts for less than 1% of all sites of primary presentations. We report the experience of the Department of Radiation Oncology at Ankara University Faculty of Medicine with radiation therapy in treatment of patients with stage I primary orbital NHL. Methods From February 1978 through August 1993, 14 patients with stage I primary orbital NHL were treated with radiation therapy. According to the Working Formulation classification, 8 patients had low-grade and 6 had intermediate-grade lymphomas. The most commonly used radiation therapy technique was a single anterior field with a Cobalt-60 unit, delivering 40 Gy in 2 Gy daily fractions. Two patients with intermediate-grade lymphomas received the CHOP regimen following radiation therapy. Results Follow-up ranged from 0.8 to 18.3 years (median, 10.3 years). Local control was achieved in all patients. Two patients with low-grade lymphomas relapsed locally and were successfully salvaged with radiation therapy. Three patients with intermediate-grade lymphomas failed systemically. Salvage therapy consisted of combination chemotherapy for 2 of them but was unsuccessful. Overall survival probabilities at 2, 5 and 10 years were 78.6%, 61.1% and 52.4%, respectively, for the entire group of 14 patients. Overall, cause-specific and disease-free survival probabilities were higher for patients with low-grade lymphomas than for those with intermediate-grade lymphomas (P = 0.03, P = 0.03 and P = 0.06, respectively). Cataracts were observed in 9 and lacrimal disorders in 4 patients. Conclusions The study suggests that among stage I primary orbital NHL, low-grade lymphomas could be treated with radiation therapy alone, whereas combination chemotherapy could accompany radiation therapy for intermediate-grade lymphomas.

Conditional Survival Probabilities for Patients With Resected Pancreatic Adenocarcinoma

2014 ◽  
Vol 37 (2) ◽  
pp. 107-111 ◽  
Author(s):  
Mark V. Mishra ◽  
Colin E. Champ ◽  
Scott W. Keith ◽  
Timothy N. Showalter ◽  
Pramila R. Anne ◽  
...  
Keyword(s):  
Pancreatic Adenocarcinoma ◽  
Conditional Survival ◽  
Survival Probabilities

scholarly journals NanOx Predictions of Cell Survival Probabilities for Three Cell Lines

2017 ◽  
Vol 48 (10) ◽  
pp. 1653 ◽  
Author(s):  
C. Monini ◽  
É. Testa ◽  
M. Beuve
Keyword(s):  
Cell Survival ◽  
Cell Lines ◽  
Survival Probabilities

Survival of red-capped robins (Petroica goodenovii) in woodland remnants of central western New South Wales, Australia

2001 ◽  
Vol 28 (6) ◽  
pp. 565 ◽  
Author(s):  
Richard E. Major ◽  
Greg Gowing
Keyword(s):  
Survival Rates ◽  
Relative Survival ◽  
Adult Mortality ◽  
Annual Survival ◽  
Survival Probabilities ◽  
South Wales ◽  
Winter Half ◽  
Linear Habitat ◽  
Significant Difference ◽  
Summer Half

To determine relative survival rates of small birds occupying small, linear strips of woodland compared with large patches of woodland, marked populations of red-capped robins were monitored over a two-year period. In total, 196 male robins were banded with unique colour combinations in 10 woodland remnants and censused by song playback at half-yearly intervals. The Cormack–Jolly–Seber method was used to calculate half-yearly survival probabilities for birds in the two habitat configurations and the strongest model included separate survival parameters for summer (36.2% 5.1) and autumn (88.9% 13.5) half-years, but a constant recapture probability (50.5% 7.2). The inclusion of separate parameters for the large and linear habitat configurations reduced the strength of the model, indicating that there was no significant difference between the survival rates of birds occupying small, linear strips of woodland and birds occupying large patches of woodland. The mean annual survival, determined by multiplying the half-yearly survival probabilities, was 32%, which is low, compared with the annual survival of other Petroica robins. Although no banded birds were located away from the banding site, we suspect that much of the ‘mortality’ represented emigration during the summer half-year. Under this scenario a better estimate of annual survival (79%) might be achieved by extrapolation of survival over the winter half-year. This study provides no data to support the contention that adult mortality is higher in small, linear strips of habitat, although further data on the fate of birds that disappear from remnants is required before this is conclusive. In addition, to detect a 20% difference in survival using similar methods to the present study, with their accompanying sources of variation, at least 10 times the number of birds would need to be monitored. This might most effectively be done as a co-operative banding project.

scholarly journals Recursive Calculation of Survival Probabilities

1991 ◽  
Vol 21 (2) ◽  
pp. 199-221 ◽  
Author(s):  
David C. M. Dickson ◽  
Howard R. Waters
Keyword(s):  
Finite Time ◽  
Approximate Calculation ◽  
Risk Model ◽  
Classical Risk Model ◽  
Infinite Time ◽  
Numerical Examples ◽  
Survival Probabilities ◽  
Recursive Calculation ◽  
The Stability ◽  
The Classical Risk Model

AbstractIn this paper we present an algorithm for the approximate calculation of finite time survival probabilities for the classical risk model. We also show how this algorithm can be applied to the calculation of infinite time survival probabilities. Numerical examples are given and the stability of the algorithms is discussed.

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