Cell-Penetrating Peptides as Carriers for Transepithelial Drug Delivery In Vitro

2015 ◽  
pp. 261-277 ◽  
Author(s):  
Stine Rønholt ◽  
Mie Kristensen ◽  
Hanne Mørck Nielsen
Keyword(s):  
Drug Delivery ◽  
Cell Penetrating Peptides ◽  
Cell Penetrating

scholarly journals Cell-Penetrating Peptides: Possibilities and Challenges for Drug Delivery in Vitro and in Vivo

Molecules ◽  
2015 ◽  
Vol 20 (7) ◽  
pp. 13313-13323 ◽  
Author(s):  
Tore Skotland ◽  
Tore Iversen ◽  
Maria Torgersen ◽  
Kirsten Sandvig
Keyword(s):  
Drug Delivery ◽  
Cell Penetrating Peptides ◽  
Cell Penetrating

siRNA versus pharmacological inhibition of endocytic pathways for studying cellular uptake of cell penetrating peptides and other drug delivery vectors

2010 ◽  
Vol 15 (23-24) ◽  
pp. 1103-1103
Author(s):  
Monerah H. Al-Soraj ◽  
Catherine L. Watkins ◽  
Dries Vercauteren ◽  
Stefaan De Smedt ◽  
Kevin Braeckmans ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cellular Uptake ◽  
Cell Penetrating Peptides ◽  
Pharmacological Inhibition ◽  
Cell Penetrating ◽  
Endocytic Pathways

scholarly journals Design and in vitro delivery of HIV-1 multi-epitope DNA and peptide constructs using novel cell-penetrating peptides

2019 ◽  
Vol 41 (11) ◽  
pp. 1283-1298 ◽  
Author(s):  
Saba Davoodi ◽  
Azam Bolhassani ◽  
Seyed Mehdi Sadat ◽  
Shiva Irani
Keyword(s):  
Cell Penetrating Peptides ◽  
Cell Penetrating ◽  
Hiv 1

Cell‐Penetrating Peptides and Polymers for Improved Drug Delivery

ChemNanoMat ◽  
2020 ◽  
Vol 6 (8) ◽  
pp. 1138-1148
Author(s):  
Lin Gui ◽  
Xue‐Hao Zhang ◽  
Zeng‐Ying Qiao ◽  
Hao Wang
Keyword(s):  
Drug Delivery ◽  
Cell Penetrating Peptides ◽  
Cell Penetrating

scholarly journals Cell-Penetrating Peptide and siRNA-Mediated Therapeutic Effects on Endometriosis and Cancer In Vitro Models

Pharmaceutics ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 1618
Author(s):  
Kristina Kiisholts ◽  
Kaido Kurrikoff ◽  
Piret Arukuusk ◽  
Ly Porosk ◽  
Maire Peters ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Cellular Proliferation ◽  
Expression Patterns ◽  
In Vitro Models ◽  
Cell Penetrating Peptides ◽  
Biologically Active ◽  
Therapeutic Effects ◽  
Cell Penetrating ◽  
Proliferation And Invasion

Gene therapy is a powerful tool for the development of new treatment strategies for various conditions, by aiming to transport biologically active nucleic acids into diseased cells. To achieve that goal, we used highly potential delivery vectors, cell-penetrating peptides (CPPs), as oligonucleotide carriers for the development of a therapeutic approach for endometriosis and cancer. Despite marked differences, both of these conditions still exhibit similarities, like excessive, uncoordinated, and autonomous cellular proliferation and invasion, accompanied by overlapping gene expression patterns. Thus, in the current study, we investigated the therapeutic effects of CPP and siRNA nanoparticles using in vitro models of benign endometriosis and malignant glioblastoma. We demonstrated that CPPs PepFect6 and NickFect70 are highly effective in transfecting cell lines, primary cell cultures, and three-dimensional spheroids. CPP nanoparticles are capable of inducing siRNA-specific knockdown of therapeutic genes, ribonucleotide reductase subunit M2 (RRM2), and vascular endothelial growth factor (VEGF), which results in the reduction of in vitro cellular proliferation, invasion, and migration. In addition, we proved that it is possible to achieve synergistic suppression of endometriosis cellular proliferation and invasion by combining gene therapy and hormonal treatment approaches by co-administering CPP/siRNA nanoparticles together with the endometriosis-drug danazol. We suggest a novel target, RRM2, for endometriosis therapy and as a proof-of-concept, we propose a CPP-mediated gene therapy approach for endometriosis and cancer.

Cyclic Cell-Penetrating Peptides as Efficient Intracellular Drug Delivery Tools

2019 ◽  
Vol 16 (9) ◽  
pp. 3727-3743 ◽  
Author(s):  
Shang Eun Park ◽  
Muhammad Imran Sajid ◽  
Keykavous Parang ◽  
Rakesh Kumar Tiwari
Keyword(s):  
Drug Delivery ◽  
Cell Penetrating Peptides ◽  
Intracellular Drug Delivery ◽  
Cell Penetrating

scholarly journals Conjugation of cell-penetrating peptides with poly(lactic-co-glycolic acid)-polyethylene glycol nanoparticles improves ocular drug delivery

2015 ◽  
pp. 609 ◽  
Author(s):  
Maria Luisa García ◽  
Yolanda Pérez ◽  
María José Gómara ◽  
Aimee Vasconcelos ◽  
Estefania Vega ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Polyethylene Glycol ◽  
Glycolic Acid ◽  
Cell Penetrating Peptides ◽  
Ocular Drug Delivery ◽  
Cell Penetrating
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