scholarly journals Identification of the Interactome of a Palmitoylated Membrane Protein, Phosphatidylinositol 4-Kinase Type II Alpha

2016 ◽  
pp. 35-42 ◽  
Author(s):  
Avanti Gokhale ◽  
Pearl V. Ryder ◽  
Stephanie A. Zlatic ◽  
Victor Faundez
Keyword(s):  
Membrane Protein ◽  
Type Ii ◽  
Phosphatidylinositol 4

scholarly journals Type II Phosphatidylinositol 4-Kinase β Is a Cytosolic and Peripheral Membrane Protein That Is Recruited to the Plasma Membrane and Activated by Rac-GTP

2002 ◽  
Vol 277 (48) ◽  
pp. 46586-46593 ◽  
Author(s):  
Yong Jie Wei ◽  
Hui Qiao Sun ◽  
Masaya Yamamoto ◽  
Pawel Wlodarski ◽  
Kaiko Kunii ◽  
...  
Keyword(s):  
Plasma Membrane ◽  
Membrane Protein ◽  
Type Ii ◽  
Peripheral Membrane Protein ◽  
Phosphatidylinositol 4

scholarly journals Retention of a type II surface membrane protein in the endoplasmic reticulum by the Lys-Asp-Glu-Leu sequence.

1992 ◽  
Vol 267 (10) ◽  
pp. 7072-7076
Author(s):  
B.L. Tang ◽  
S.H. Wong ◽  
S.H. Low ◽  
W Hong
Keyword(s):  
Endoplasmic Reticulum ◽  
Membrane Protein ◽  
Surface Membrane ◽  
Type Ii

scholarly journals Biphasic regulation of type II phosphatidylinositol-4 kinase by sphingosine: Cross talk between glycero- and sphingolipids in the kidney

2014 ◽  
Vol 1838 (3) ◽  
pp. 1003-1009 ◽  
Author(s):  
Thiago Lemos ◽  
Karine S. Verdoorn ◽  
Luciana Nogaroli ◽  
Thiago Britto-Borges ◽  
Thaís A. Bonilha ◽  
...  
Keyword(s):  
Cross Talk ◽  
Type Ii ◽  
Phosphatidylinositol 4

II. Yeast sequencing reports. The nucleotide sequence ofTTP1, a gene encoding a predicted type II membrane protein

Yeast ◽  
1994 ◽  
Vol 10 (8) ◽  
pp. 1111-1115 ◽  
Author(s):  
Pedro A. Romero ◽  
Ariadni Athanassiadis ◽  
Marc Lussier ◽  
Annette Herscovics
Keyword(s):  
Nucleotide Sequence ◽  
Membrane Protein ◽  
Type Ii ◽  
Gene Encoding ◽  
Type Ii Membrane Protein

Phosphatidylinositol 4-Kinase Type II Alpha

2018 ◽  
pp. 3934-3939
Author(s):  
Yassmeen Radif ◽  
Mark G. Waugh
Keyword(s):  
Type Ii ◽  
Phosphatidylinositol 4

Nuclear localization of phosphatidylinositol 4-kinase β

2002 ◽  
Vol 115 (8) ◽  
pp. 1769-1775 ◽  
Author(s):  
Petra de Graaf ◽  
Elsa E. Klapisz ◽  
Thomas K. F. Schulz ◽  
Alfons F. M. Cremers ◽  
Arie J. Verkleij ◽  
...  
Keyword(s):  
Nuclear Export ◽  
Kinase Activity ◽  
Insoluble Fraction ◽  
Type Ii ◽  
3T3 Cells ◽  
Type Iii ◽  
Pore Complexes ◽  
Phosphatidylinositol 4 ◽  
Nih 3T3 ◽  
Nih 3T3 Cells

Whereas most phosphatidylinositol 4-kinase (PtdIns 4-kinase) activity is localized in the cytoplasm, PtdIns 4-kinase activity has also been detected in membranedepleted nuclei of rat liver and mouse NIH 3T3 cells. Here we have characterized the PtdIns 4-kinase that is present in nuclei from NIH 3T3 cells. Both type II and type III PtdIns 4-kinase activity were observed in the detergent-insoluble fraction of NIH 3T3 cells. Dissection of this fraction into cytoplasmic actin filaments and nuclear lamina-pore complexes revealed that the actin filament fraction contains solely type II PtdIns 4-kinase,whereas lamina-pore complexes contain type III PtdIns 4-kinase activity. Using specific antibodies, the nuclear PtdIns 4-kinase was identified as PtdIns 4-kinase β. Inhibition of nuclear export by leptomycin B resulted in an accumulation of PtdIns 4-kinase β in the nucleus. These data demonstrate that PtdIns 4-kinase β is present in the nuclei of NIH 3T3 fibroblasts,suggesting a specific function for this kinase in nuclear processes.

scholarly journals ATG9A shapes the forming autophagosome through Arfaptin 2 and phosphatidylinositol 4-kinase IIIβ

2019 ◽  
Vol 218 (5) ◽  
pp. 1634-1652 ◽  
Author(s):  
Delphine Judith ◽  
Harold B.J. Jefferies ◽  
Stefan Boeing ◽  
David Frith ◽  
Ambrosius P. Snijders ◽  
...  
Keyword(s):  
Quantitative Analysis ◽  
Amino Acid ◽  
Membrane Protein ◽  
Initiation Site ◽  
Amino Acid Starvation ◽  
Autophagosome Formation ◽  
Metabolizing Enzymes ◽  
Bar Domain ◽  
Golgi Membranes ◽  
Phosphatidylinositol 4

ATG9A is a multispanning membrane protein essential for autophagy. Normally resident in Golgi membranes and endosomes, during amino acid starvation, ATG9A traffics to sites of autophagosome formation. ATG9A is not incorporated into autophagosomes but is proposed to supply so-far-unidentified proteins and lipids to the autophagosome. To address this function of ATG9A, a quantitative analysis of ATG9A-positive compartments immunoisolated from amino acid–starved cells was performed. These ATG9A vesicles are depleted of Golgi proteins and enriched in BAR-domain containing proteins, Arfaptins, and phosphoinositide-metabolizing enzymes. Arfaptin2 regulates the starvation-dependent distribution of ATG9A vesicles, and these ATG9A vesicles deliver the PI4-kinase, PI4KIIIβ, to the autophagosome initiation site. PI4KIIIβ interacts with ATG9A and ATG13 to control PI4P production at the initiation membrane site and the autophagic response. PI4KIIIβ and PI4P likely function by recruiting the ULK1/2 initiation kinase complex subunit ATG13 to nascent autophagosomes.

scholarly journals A monoclonal antibody distinguishes two types of phosphatidylinositol 4-kinase

1991 ◽  
Vol 273 (1) ◽  
pp. 63-66 ◽  
Author(s):  
G C Endemann ◽  
A Graziani ◽  
L C Cantley
Keyword(s):  
Monoclonal Antibody ◽  
Rat Brain ◽  
Rat Liver ◽  
Bovine Brain ◽  
Human Erythrocytes ◽  
Gene Products ◽  
Type Ii ◽  
Type Iii ◽  
Distinct Gene ◽  
Phosphatidylinositol 4

A monoclonal antibody has been developed against the type II PtdIns 4-kinase from bovine brain. This antibody, 4C5G, causes greater than 90% inhibition of the type II PtdIns 4-kinase from bovine brain, rat brain and human erythrocytes. However, it fails to inhibit type III PtdIns 4-kinase from bovine brain or PtdIns 3-kinase from rat liver. These results suggest that type II and type III PtdIns 4-kinases are distinct gene products, and that 4C5G will be useful in studying the function of the type II PtdIns 4-kinase.

Type II phosphatidylinositol 4-kinases promote Listeria monocytogenes entry into target cells

2007 ◽  
Vol 9 (10) ◽  
pp. 2381-2390 ◽  
Author(s):  
Javier Pizarro-Cerdá ◽  
Bernard Payrastre ◽  
Ying-Jie Wang ◽  
Esteban Veiga ◽  
Helen L. Yin ◽  
...  
Keyword(s):  
Listeria Monocytogenes ◽  
Target Cells ◽  
Type Ii ◽  
Phosphatidylinositol 4

scholarly journals beta-Amyloid protein converting enzyme 1 and brain-specific type II membrane protein BRI3: binding partners processed by furin

2005 ◽  
Vol 92 (1) ◽  
pp. 93-102 ◽  
Author(s):  
Louise Wickham ◽  
Suzanne Benjannet ◽  
Edwige Marcinkiewicz ◽  
Michel Chretien ◽  
Nabil G. Seidah
Keyword(s):  
Membrane Protein ◽  
Beta Amyloid ◽  
Type Ii ◽  
Amyloid Protein ◽  
Converting Enzyme ◽  
Binding Partners ◽  
Beta Amyloid Protein ◽  
Type Ii Membrane Protein
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