Methods to Study Long Noncoding RNA Expression and Dynamics in Zebrafish Using RNA Sequencing

2019 ◽  
pp. 77-110
Author(s):  
Samatha Mathew ◽  
Ambily Sivadas ◽  
Paras Sehgal ◽  
Kriti Kaushik ◽  
Shamsudheen K. Vellarikkal ◽  
...  
Keyword(s):  
Rna Sequencing ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Rna Expression

Knockdown of long noncoding RNA AC245100.4 inhibits the tumorigenesis of prostate cancer cells via the STAT3/NR4A3 axis

Epigenomics ◽  
2021 ◽  
Author(s):  
Chi Liu ◽  
Ping Lin ◽  
Jiabin Zhao ◽  
Hui Xie ◽  
Rou Li ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Rna Sequencing ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Transcriptional Repressor ◽  
Sequencing Analysis ◽  
Loss Of Function ◽  
Prostate Cancer Cells ◽  
Rna Immunoprecipitation

Aim: To explore the role and mechanism of long noncoding RNA AC245100.4 and NR4A3 in prostate cancer (PCa). Methods: RNA-sequencing analysis was used to detect the downstream genes of AC245100.4. A series of gain- and loss-of-function approaches were used to investigate the roles of AC245100.4 and NR4A3. RNA immunoprecipitation was performed to examine the interaction between AC245100.4 and STAT3. Results: AC245100.4 was significantly upregulated in PCa cells and tissues. Knockdown of AC21500.4 significantly inhibited the tumorigenesis of PCa cells. Mechanistically, AC245100.4 deregulated the transcription of NR4A3 via increasing p-STAT3, which acted as a transcriptional repressor of NR4A3. Conclusion: Knockdown of lncRNA AC245100.4 inhibits the tumorigenesis of PCa cells via the STAT3/ NR4A3 axis.

Detection of Long Noncoding RNA Expression by

2021 ◽  
pp. 35-42
Author(s):  
Rui Huang ◽  
Yihao Wang ◽  
Yaqi Deng ◽  
Jianfeng Shen
Keyword(s):  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Rna Expression

scholarly journals Long noncoding RNA expression profile from cryptococcal meningitis patients identifies DPY19L1p1 as a new disease marker

2019 ◽  
Vol 25 (6) ◽  
pp. 772-782 ◽  
Author(s):  
Lei Zhang ◽  
Wen‐Jie Fang ◽  
Ke‐Ming Zhang ◽  
Wei‐Wei Jiang ◽  
Min Chen ◽  
...  
Keyword(s):  
Expression Profile ◽  
Cryptococcal Meningitis ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Rna Expression ◽  
New Disease ◽  
Disease Marker
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