Statins, Oxidative Stress, and Polycystic Ovary Syndrome

2007 ◽  
pp. 263-278
Author(s):  
Pinar H. Kodaman ◽  
Antoni J. Duleba
Keyword(s):  
Oxidative Stress ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Ovary Syndrome

Oxidative stress markers in women with polycystic ovary syndrome without insulin resistance

2018 ◽  
Author(s):  
Reveka Gyftaki ◽  
Sofia Gougoura ◽  
Nikolaos Kalogeris ◽  
Vasiliki Loi ◽  
George Koukoulis ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Insulin Resistance ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Oxidative Stress Markers ◽  
Ovary Syndrome ◽  
Stress Markers

scholarly journals The progesterone receptor PROGINS polymorphism is not related to oxidative stress factors in women with polycystic ovary syndrome

2007 ◽  
Vol 6 (1) ◽  
pp. 29 ◽  
Author(s):  
Muammer Karadeniz ◽  
Mehmet Erdogan ◽  
Afig Berdeli ◽  
Sadik Tamsel ◽  
Fusun Saygili ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Progesterone Receptor ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Stress Factors ◽  
Ovary Syndrome

scholarly journals Relationship between parasympathetic reactivity and oxidative stress in Polycystic ovary syndrome

2020 ◽  
Vol 14 (2) ◽  
pp. 48-55
Author(s):  
Ayesha Akhter ◽  
Sultana Ferdousi ◽  
Shamima Sultana ◽  
Musfika Mostafa
Keyword(s):  
Oxidative Stress ◽  
Heart Rate ◽  
Regression Analysis ◽  
Polycystic Ovary Syndrome ◽  
Multiple Regression Analysis ◽  
Polycystic Ovary ◽  
Ovary Syndrome ◽  
Healthy Control ◽  
And Oxidative Stress ◽  
Plasma Malondialdehyde

Background: Polycystic ovary syndrome (PCOS) is a very common reproductive hormone disorder. Altered cardiovagal autonomic modulation and oxidative stress may predispose PCOS patients to increased cardiovascular morbidity. Objective: To assess the relationship between parasympathetic reactivity and oxidative stress in patients with PCOS. Methods: This crosssectional study was conducted in the Department of Physiology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Shahbagh, Dhaka from September 2018 to August 2019 on 35 newly diagnosed obese (BMI ≥25kg/m2) PCOS patients aged 20-35 years. Age and BMI matched 35 apparently healthy women were also enrolled as control. Three noninvasive conventional autonomic function tests, such as heart rate response to deep breathing, standing and the Valsalva maneuver, were used for evaluation of parasympathetic reactivity. For assessment of oxidative stress, plasma malondialdehyde level (oxidant) and plasma catalase level(antioxidant) were measured in all subjects by spectrophotometry. Data were expressed as mean± SD. For statistical analysis Independent sample “t” test, Pearson’s correlation test and multiple regression analysis were done as applicable. Results: In this study PCOS patients had significantly higher (p<0.01)resting heart rate, systolic and diastolic blood pressure than that of healthy control. But Expiration: Inspiration ratio, Expiration:Inspiration difference and 30:15 ratio during standing were significantly lower (p<0.001, p<0.01 and p<0.05 respectively) in PCOS compared to control. In addition, plasma catalase level was significantly lower (p<0.01)and plasma malondialdehyde level significantly higher (p<0.001) in PCOS in comparison to healthy control. Multiple regression analysis showed plasma catalase as a significant positive predictor (p<0.05) of the Valsalva ratio in PCOS. Also, Valsalva ratio showed significant negative association (p<0.05) with plasma malondialdehyde (p<0.01)in PCOS. Conclusion: Based on these results it is concluded that impaired parasympathetic reactivity showed inverse relationship with oxidative stress in PCOS. J Bangladesh Soc Physiol. 2019, December; 14(2): 48-55

scholarly journals Hydroxysafflor yellow A exerts beneficial effects by restoring hormone secretion and alleviating oxidative stress in polycystic ovary syndrome mice

2020 ◽  
Vol 105 (2) ◽  
pp. 282-292 ◽  
Author(s):  
Man Luo ◽  
Ji‐Cheng Huang ◽  
Zhan‐Qing Yang ◽  
Yu‐Si Wang ◽  
Bin Guo ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Hormone Secretion ◽  
Hydroxysafflor Yellow A ◽  
Ovary Syndrome ◽  
Beneficial Effects

Thymoquinone reduces intracytoplasmic oxidative stress and improves epigenetic modification in polycystic ovary syndrome mice oocytes, during in‐vitro maturation

2019 ◽  
Vol 86 (8) ◽  
pp. 1053-1066 ◽  
Author(s):  
Fatemeh Eini ◽  
Arash Bidadkosh ◽  
Hamid Nazarian ◽  
Abbas Piryaei ◽  
Marefat Ghaffari Novin ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Polycystic Ovary Syndrome ◽  
In Vitro Maturation ◽  
Polycystic Ovary ◽  
Epigenetic Modification ◽  
Ovary Syndrome

scholarly journals Inositol administration reduces oxidative stress in erythrocytes of patients with polycystic ovary syndrome

2012 ◽  
Vol 166 (4) ◽  
pp. 703-710 ◽  
Author(s):  
Gabriella Donà ◽  
Chiara Sabbadin ◽  
Cristina Fiore ◽  
Marcantonio Bragadin ◽  
Francesco L Giorgino ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Serum Insulin ◽  
Band 3 ◽  
Oral Glucose ◽  
Fasting Serum ◽  
Ovary Syndrome ◽  
Inflammatory Status ◽  
Before And After

ObjectivePossibly due to a deficiency of insulin mediators, polycystic ovary syndrome (PCOS) is often associated with insulin resistance (IR) and hyperinsulinemia, likely responsible for an elevated production of reactive oxygen species. We investigated oxidative-related alterations in erythrocytes and anti-inflammatory effects of inositol in women with PCOS before and after treatment with myo-inositol (MYO).MethodsTwenty-six normal-weight PCOS patients were investigated before and after MYO administration (1200 mg/day for 12 weeks;n=18) or placebo (n=8) by evaluating serum testosterone, serum androstenedione, fasting serum insulin, fasting serum glucose, insulin area under the curve (AUC), and glucose AUC after oral glucose tolerance test and homeostasis model of assessment–IR. In erythrocytes, band 3 tyrosine phosphorylation (Tyr-P) level, glutathione (GSH) content, and glutathionylated proteins (GSSP) were also assessed.ResultsData show that PCOS patients' erythrocytes underwent oxidative stress as indicated by band 3 Tyr-P values, reduced cytosolic GSH content, and increased membrane protein glutathionylation. MYO treatment significantly improved metabolic and biochemical parameters. Significant reductions were found in IR and serum values of androstenedione and testosterone. A significant association between band 3 Tyr-P levels and insulin AUC was found at baseline but disappeared after MYO treatment, while a correlation between band 3 Tyr-P and testosterone levels was detected both before and after MYO treatment.ConclusionsPCOS patients suffer from a systemic inflammatory status that induces erythrocyte membrane alterations. Treatment with MYO is effective in reducing hormonal, metabolic, and oxidative abnormalities in PCOS patients by improving IR.

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