Characterization of the Antioxidant Properties of Pentaerithrityl Tetranitrate (PETN)-Induction of the Intrinsic Antioxidative System Heme Oxygenase-1 (HO-1)

2009 ◽  
pp. 311-326 ◽  
Author(s):  
Andreas Daiber ◽  
Thomas Münzel
Keyword(s):  
Heme Oxygenase ◽  
Antioxidant Properties ◽  
Antioxidative System ◽  
Heme Oxygenase 1

scholarly journals 1P159 EPR Characterization of the heme complex of a higher plant heme oxygenase-1(5. Heme protein,Poster Session,Abstract,Meeting Program of EABS & BSJ 2006)

2006 ◽  
Vol 46 (supplement2) ◽  
pp. S186
Author(s):  
Tomohiko Goya ◽  
Xuhong Zhang ◽  
Tadashi Yoshida ◽  
Catharina_T. Migita
Keyword(s):  
Heme Oxygenase ◽  
Poster Session ◽  
Heme Protein ◽  
Heme Oxygenase 1 ◽  
Higher Plant ◽  
Meeting Program

scholarly journals Characterization of hepatic macrophages and evaluation of inflammatory response in heme oxygenase-1 deficient mice exposed to scAAV9 vectors

PLoS ONE ◽  
2020 ◽  
Vol 15 (10) ◽  
pp. e0240691
Author(s):  
Mateusz Tomczyk ◽  
Izabela Kraszewska ◽  
Robert Mąka ◽  
Agnieszka Waligórska ◽  
Józef Dulak ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Heme Oxygenase ◽  
Heme Oxygenase 1 ◽  
Hepatic Macrophages ◽  
Deficient Mice

Structural characterization of human heme oxygenase-1 in complex with azole-based inhibitors

2010 ◽  
Vol 104 (3) ◽  
pp. 324-330 ◽  
Author(s):  
Mona N. Rahman ◽  
Jason Z. Vlahakis ◽  
Gheorghe Roman ◽  
Dragic Vukomanovic ◽  
Walter A. Szarek ◽  
...  
Keyword(s):  
Heme Oxygenase ◽  
Structural Characterization ◽  
Heme Oxygenase 1

Isolation and Characterization of a Heme Oxygenase-1 Gene from Chinese Cabbage

2011 ◽  
Vol 50 (1) ◽  
pp. 8-17 ◽  
Author(s):  
Qi-Jiang Jin ◽  
Xing-Xing Yuan ◽  
Wei-Ti Cui ◽  
Bin Han ◽  
Jian-Fei Feng ◽  
...  
Keyword(s):  
Heme Oxygenase ◽  
Chinese Cabbage ◽  
Heme Oxygenase 1 ◽  
Isolation And Characterization

Characterization of the Arabidopsis thaliana heme oxygenase 1 promoter in response to salinity, iron deficiency, and mercury exposure

2017 ◽  
Vol 61 (1) ◽  
pp. 35-47 ◽  
Author(s):  
F.-Q. Wang ◽  
J. Yang ◽  
C. Dai ◽  
M.-Z. Wu ◽  
Y.-H. Zhang ◽  
...  
Keyword(s):  
Arabidopsis Thaliana ◽  
Iron Deficiency ◽  
Heme Oxygenase ◽  
Mercury Exposure ◽  
Heme Oxygenase 1

scholarly journals Heme-Oxygenase-1 Attenuates Oxidative Functions of Antigen Presenting Cells and Promotes Regulatory T Cell Differentiation during Fasciola hepatica Infection

Antioxidants ◽  
2021 ◽  
Vol 10 (12) ◽  
pp. 1938
Author(s):  
Monique Costa ◽  
Valeria da Costa ◽  
Sofía Frigerio ◽  
María Florencia Festari ◽  
Mercedes Landeira ◽  
...  
Keyword(s):  
Heme Oxygenase ◽  
Molecular Mechanisms ◽  
Fasciola Hepatica ◽  
Antioxidant Properties ◽  
Antigen Presenting Cells ◽  
Parasite Infection ◽  
Economic Losses ◽  
Heme Oxygenase 1 ◽  
Host Immune System ◽  
Antigen Presenting

Fasciola hepatica is a fluke that infects livestock and humans causing fasciolosis, a zoonotic disease of increasing importance due to its worldwide distribution and high economic losses. The parasite regulates the host immune system by inducing a strong Th2 and regulatory T (Treg) cell immune response through mechanisms that might involve the expression or activity of heme-oxygenase-1 (HO-1), the rate-limiting enzyme in the catabolism of free heme that also has immunoregulatory and antioxidant properties. In this paper, we show that F. hepatica-infected mice upregulate HO-1 on peritoneal antigen-presenting cells (APC), which produce decreased levels of both reactive oxygen and nitrogen species (ROS/RNS). The presence of these cells was associated with increased levels of regulatory T cells (Tregs). Blocking the IL-10 receptor (IL-10R) during parasite infection demonstrated that the presence of splenic Tregs and peritoneal APC expressing HO-1 were both dependent on IL-10 activity. Furthermore, IL-10R neutralization as well as pharmacological treatment with the HO-1 inhibitor SnPP protected mice from parasite infection and allowed peritoneal APC to produce significantly higher ROS/RNS levels than those detected in cells from infected control mice. Finally, parasite infection carried out in gp91phox knockout mice with inactive NADPH oxidase was associated with decreased levels of peritoneal HO-1+ cells and splenic Tregs, and partially protected mice from the hepatic damage induced by the parasite, revealing the complexity of the molecular mechanisms involving ROS production that participate in the complex pathology induced by this helminth. Altogether, these results contribute to the elucidation of the immunoregulatory and antioxidant role of HO-1 induced by F. hepatica in the host, providing alternative checkpoints that might control fasciolosis.

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