Nutraceuticals in Dermatological Disorders

Bruton tyrosine kinase (Btk) is expressed in B-lymphocytes, myeloid cells and platelets, and Btk-inhibitors (BTKi) are used to treat patients with B-cell malignancies, developed against autoimmune diseases, have been proposed as novel antithrombotic drugs, and been tested in patients with severe COVID-19. However, mild bleeding is frequent in patients with B-cell malignancies treated with the irreversible BTKi ibrutinib and the recently approved 2nd generation BTKi acalabrutinib, zanubrutinib and tirabrutinib, and also in volunteers receiving in a phase-1 study the novel irreversible BTKi BI-705564. In contrast, no bleeding has been reported in clinical trials of other BTKi. These include the brain-penetrant irreversible tolebrutinib and evobrutinib (against multiple sclerosis), the irreversible branebrutinib, the reversible BMS-986142 and fenebrutinib (targeting rheumatoid arthritis and lupus erythematodes), and the reversible covalent rilzabrutinib (against pemphigus and immune thrombocytopenia). Remibrutinib, a novel highly selective covalent BTKi, is currently in clinical studies of autoimmune dermatological disorders. This review describes twelve BTKi approved or in clinical trials. By focusing on their pharmacological properties, targeted disease, bleeding side effects and actions on platelets it attempts to clarify the mechanisms underlying bleeding. Specific platelet function tests in blood might help to estimate the probability of bleeding of newly developed BTKi.

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Clinical applications for topical 5-fluorouracil in the treatment of dermatological disorders

Journal of Dermatological Treatment ◽

10.3109/09546630902789326 ◽

2009 ◽

Vol 20 (6) ◽

pp. 328-335 ◽

Cited By ~ 42

Author(s):

Angela Yen Moore

Keyword(s):

Clinical Applications ◽

Dermatological Disorders

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Oral leukoplakia and other white lesions of the oral mucosa related to dermatological disorders

Journal of Cutaneous Pathology ◽

10.1111/j.1600-0560.1983.tb01490.x ◽

1983 ◽

Vol 10 (4) ◽

pp. 238-256 ◽

Cited By ~ 9

Author(s):

J. Banoaczy

Keyword(s):

Oral Mucosa ◽

Oral Leukoplakia ◽

Dermatological Disorders

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Derivation of marker gene signatures from human skin and their use in the interpretation of the transcriptional changes associated with dermatological disorders

The Journal of Pathology ◽

10.1002/path.4864 ◽

2017 ◽

Vol 241 (5) ◽

pp. 600-613 ◽

Cited By ~ 9

Author(s):

Barbara B Shih ◽

Ajit J Nirmal ◽

Denis J Headon ◽

Arne N Akbar ◽

Neil A Mabbott ◽

...

Keyword(s):

Human Skin ◽

Marker Gene ◽

Gene Signatures ◽

Transcriptional Changes ◽

Dermatological Disorders

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Erythema Nodosum and Pyoderma Gangrenosum in 50 Patients with Crohn’s Disease

Canadian Journal of Gastroenterology ◽

10.1155/2005/323914 ◽

2005 ◽

Vol 19 (10) ◽

pp. 603-606 ◽

Cited By ~ 32

Author(s):

Hugh J Freeman

Keyword(s):

Crohn’S Disease ◽

Crohn's Disease ◽

Pyoderma Gangrenosum ◽

Complex Disease ◽

Erythema Nodosum ◽

Colonic Disease ◽

Detection Rates ◽

Dependent Effect ◽

Age Dependent ◽

Dermatological Disorders

Erythema nodosum and pyoderma gangrenosum may occur in Crohn's disease. In the present evaluation of consecutive patients with Crohn's disease spanning more than two decades, erythema nodosum was seen in 45 patients and pyoderma gangrenosum was seen in seven patients. Forty-one of 566 women (7.2%) and nine of 449 men (2.0%) were affected. Of these, 45 (4.4%) had erythema nodosum and seven (0.7%) had pyoderma gangrenosum, including two (0.2%) with both dermatological disorders at different times during their clinical courses. Recurrent erythema nodosum was also detected in nine patients (20%) including eight women, while recurrent pyoderma gangrenosum was seen in two patients (28.6%). There was an age-dependent effect on the appearance of erythema nodosum in women, with the highest percentages seen in those younger than 20 years of age. Detection rates for erythema nodosum in women only approached the low mens' rates in Crohn's disease at older than 40 years of age. Most patients with these dermatological disorders had colonic disease with or without ileal involvement as well as complex disease, usually with penetrating complications. The present study documents a sex-based and age-dependent effect on the clinical expression of erythema nodosum in Crohn's disease. This suggests that some components of the inflammatory process in Crohn's disease may be modulated by estrogen-mediated events, particularly in adolescents and young adults.

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Dermatological Disorders Sourcebook, ed 2

Physical Therapy ◽

10.2522/ptj.2006.86.11.1570.2 ◽

2006 ◽

Vol 86 (11) ◽

pp. 1571-1571

Author(s):

Cynthia K Scott

Keyword(s):

Dermatological Disorders

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TRADITIONAL PHYTOTHERAPY USED BY BHUTIA COMMUNITY OF UTTARKASHI DISTRICT OF UTTARAKHAND FOR DERMATOLOGICAL DISORDERS

10.36106/ijar/7820999 ◽

2021 ◽

pp. 77-82

Author(s):

Arun K. Agrawal ◽

Usha Devi ◽

S.K. Kuriyal

Keyword(s):

Medicinal Plants ◽

Indigenous Knowledge ◽

Plant Species ◽

Primary Healthcare ◽

Skin Diseases ◽

Practical Knowledge ◽

Traditional Healers ◽

Tribal Community ◽

Tribal People ◽

Dermatological Disorders

Ethno-medicinal survey was undertaken from traditional healers of Bhutia tribal community of Urrarkashi district for the use of medicinal plants in the treatment of different skin diseases such as dog and insect bite, burns, eczema, abscesses, scabies, ringworm, cuts and wounds, boils, leprosy, blisters, allergy, itching, pimples, leucoderma, prickly heat, warts, septic ulcers, and other skin diseases during different season of March 2016 to May 2017. The indigenous knowledge of tribal traditional healers having practical knowledge of plants in medicine were interviewed in ve villages of Uttarkashi district of Uttarakhand and plants used for medicinal purposes were collected through questionnaire and personal interviews during eldtrips. A total of 60 plant species of 43 families are documented in this study. The medicinal plants used in the treatment of skin diseases by tribal's are listed with botanical name (in binomial form), family, local names, habit, availability, parts used, and mode of preparation. This study showed that Bhutia tribal people in the studied parts of Uttarkashi district continue to depend on the medicinal plants at least for the treatment of primary healthcare.

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