Malignant Arrhythmias and Sudden Cardiac Death in Patients with Noncompaction Cardiomyopathy: Prevalence, Prevention, and Use of Implantable Cardiac Defibrillators

Commotio cordis is an increasingly reported fatal mechano-electric syndrome and is the second most common cause of sudden cardiac death in young athletes. It is most commonly associated with a sports-related injury, wherein, there is a high-velocity impact between a projectile and the precordium. By virtue of this impact, malignant arrhythmias consequently develop leading to the individual’s immediate demise, accompanied by a relatively normal post-mortem analysis. The importance of an autopsy remains paramount to exclude other causes of sudden death. With increasing awareness and reporting, survival rates are beginning to improve; however, prevention of the development of this condition remains the best approach for survival.

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Noncompaction of Ventricular Wall - A Threat to Life

University Heart Journal ◽

10.3329/uhj.v7i1.10209 ◽

2012 ◽

Vol 7 (1) ◽

pp. 39-41

Author(s):

Nilufar Fatema ◽

Ahmed Saiful Bari ◽

Naznin Sultana ◽

Mohammad Al Mamun ◽

SM Mustafa Sultan ◽

...

Keyword(s):

Sudden Cardiac Death ◽

Early Detection ◽

Left Ventricle ◽

Cardiac Death ◽

Ventricular Wall ◽

Systemic Embolism ◽

Ventricular Noncompaction ◽

Noncompaction Cardiomyopathy ◽

Threat To Life ◽

Clinical Problems

Ventricular noncompaction is a kind of cardiomyopathy which is called Noncompaction Cardiomyopathy (NCC). In this condition in which the muscular wall of the main pumping chamber of the heart -the left ventricle (LV) appears to be spongy and non-compacted, consisting of a meshwork of numerous muscle bands called trabeculations. Here, anatomically LV wall has deep trabeculations. This condition is associated major clinical problems like systolic and diastolic dysfunction, arrhythmia and even systemic embolism. Sudden cardiac death may occur in this group. Early detection of this condition may help to plan the management. DOI: http://dx.doi.org/10.3329/uhj.v7i1.10209 UHJ 2011; 7(1): 39-41

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Sudden cardiac death in isolated right ventricular hypertrabeculation/noncompaction cardiomyopathy

Annals of Noninvasive Electrocardiology ◽

10.1111/anec.12487 ◽

2017 ◽

Vol 23 (4) ◽

pp. e12487

Author(s):

Soad Bekheit ◽

Boutros Karam ◽

Farshid Daneshvar ◽

Julie Zaidan ◽

Rabih Tabet ◽

...

Keyword(s):

Sudden Cardiac Death ◽

Right Ventricular ◽

Cardiac Death ◽

Noncompaction Cardiomyopathy

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Molecular and genetic background of sudden cardiac death

Orvosi Hetilap ◽

10.1556/oh.2012.29498 ◽

2012 ◽

Vol 153 (50) ◽

pp. 1967-1983

Author(s):

József Simkó ◽

Zoltán Szabó ◽

Kitti Barta ◽

Dóra Újvárosi ◽

Péter Nánási ◽

...

Keyword(s):

Sudden Cardiac Death ◽

Current Literature ◽

Myocardial Ischaemia ◽

Genetic Background ◽

Cardiac Death ◽

Entire Population ◽

Intracellular Ca ◽

Cardiac Autonomic Innervation ◽

Malignant Arrhythmias

Despite recent findings on the functional, structural and genetic background of sudden cardiac death, the incidence is still relatively high in the entire population. A thorough knowledge on susceptibility, as well as pathophysiology behind the development of malignant arrhythmias will help us to identify individuals at risk and prevent sudden cardiac death. This article presents a review of the current literature on the role of altered intracellular Ca2+ handling, acute myocardial ischaemia, cardiac autonomic innervation, renin-angiotensin-aldosterone system, monogenic and complex heritability in the pathogenesis of sudden cardiac death. Orv. Hetil., 2012, 153, 1967–1983.

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