Validity Frame Driven Computational Design Synthesis for Complex Cyber-Physical Systems

2020 ◽  
pp. 82-90
Author(s):  
Bert Van Acker ◽  
Yon Vanommeslaeghe ◽  
Paul De Meulenaere ◽  
Joachim Denil
Keyword(s):  
Computational Design ◽  
Cyber Physical Systems ◽  
Design Synthesis ◽  
Physical Systems ◽  
Computational Design Synthesis

scholarly journals Closed Shell Iron(IV) Oxo Complex with an Fe–O Triple Bond: Computational Design, Synthesis, and Reactivity

2020 ◽  
Vol 59 (51) ◽  
pp. 23137-23144
Author(s):  
Erik Andris ◽  
Koen Segers ◽  
Jaya Mehara ◽  
Lubomír Rulíšek ◽  
Jana Roithová
Keyword(s):  
Triple Bond ◽  
Computational Design ◽  
Closed Shell ◽  
Design Synthesis ◽  
Computational Design Synthesis

Computational design, synthesis and utilization of a magnetic molecularly imprinted polymer on graphene oxide nanosheets for highly selective extraction and determination of buprenorphine in biological fluids and tablets

2018 ◽  
Vol 10 (43) ◽  
pp. 5214-5226 ◽  
Author(s):  
Farideh Ganjavi ◽  
Mehdi Ansari ◽  
Maryam Kazemipour ◽  
Leila Zeidabadinejad
Keyword(s):  
Biological Fluids ◽  
Computational Design ◽  
Selective Extraction ◽  
Graphene Oxide Nanosheets ◽  
Imprinted Polymer ◽  
Design Synthesis ◽  
Molecularly Imprinted ◽  
Plasma And Urine Samples ◽  
Computational Design Synthesis

A magnetic MIP for the selective extraction of buprenorphine (BUP) from real plasma and urine samples and tablets based on computational design as a novel procedure has been developed.

Toward an automated approach to the design of sheet metal components

2003 ◽  
Vol 17 (3) ◽  
pp. 187-204 ◽  
Author(s):  
ADITYA SOMAN ◽  
SWAPNIL PADHYE ◽  
MATTHEW I. CAMPBELL
Keyword(s):  
Sheet Metal ◽  
User Interaction ◽  
Computational Design ◽  
Design Synthesis ◽  
Manufacturing Operations ◽  
Grammar Rules ◽  
Computational Design Synthesis ◽  
Representation Scheme ◽  
Sheet Metal Component ◽  
Synthesis Approach

The design of sheet metal components is perhaps one of the more challenging concurrent activities for design and manufacturing engineers. To aid this design process, a method is developed to encapsulate the constraints of sheet metal that make designing such components a tedious and iterative procedure. This project involves the implementation and testing of a geometric representation scheme for building feasible sheet metal components through the use of 17 grammar rules that capture manufacturing operations like cutting and bending. The implemented system has benefits both as a user interaction tool and as the basis for a computational design synthesis approach for designing sheet metal components. An example of a constructed sheet metal component is shown along with the method for invoking the sheet metal grammar to create this component.

Computational Design, Synthesis and Application of a New Selective Molecularly Imprinted Polymer for Electrochemical Detection

2016 ◽  
Vol 28 (7) ◽  
pp. 1530-1538 ◽  
Author(s):  
Nour T. Abdel Ghani ◽  
Rasha Mohamed El Nashar ◽  
Fatehy M. Abdel-Haleem ◽  
Adel Madbouly
Keyword(s):  
Electrochemical Detection ◽  
Molecularly Imprinted Polymer ◽  
Computational Design ◽  
Imprinted Polymer ◽  
Design Synthesis ◽  
Molecularly Imprinted ◽  
Computational Design Synthesis

scholarly journals Computational design, Synthesis of 4,6-dihydroxy-2-phenyl-1-benzofuran-3(2H)-one derivatives as new leads for anti-cancer activity

2019 ◽  
Vol 10 (2) ◽  
pp. 896-908
Author(s):  
Raghava Doonaboyina ◽  
Abhilasha Mittal ◽  
Sridhar Babu Gummadi
Keyword(s):  
Hydrochloric Acid ◽  
Sodium Acetate ◽  
Cancer Cell Line ◽  
Computational Design ◽  
Computational Tools ◽  
Design Synthesis ◽  
Anti Cancer ◽  
Phenyl Acetonitrile ◽  
Computational Design Synthesis ◽  
Cancer Activity

Benzofuranone is a bicyclic ring where a benzene ring fused with a furanone. Computation chemistry plays a major role in the development of new lead molecules. Computational tools docking, virtual screening, ADMET prediction are utilised in the identification of new lead molecules. Synthetic chemistry plays a major in developing a series of potent anti-cancer agents. Benzofuranone was synthesized by reacting benzene diols, and triols with bromo phenyl acetonitrile yielded an imine derivative are converted to a ketone with treatment with hydrochloric acid then cyclised with sodium acetate. The compounds identity and purity were confirmed by spectral and analytical methods. Benzofuranone derivatives are screened antineoplastic activity was performed against human skin cancer cell line G361 at micro molecular concentrations. The compounds IA, IB, ID, IE, IF, was found to be with potent activity.

New Advances in the Functional Modeling of Electro-Mechanical Components

2002 ◽  
Author(s):  
Matthew I. Campbell ◽  
Advait Limaye
Keyword(s):  
Computational Design ◽  
Human Mind ◽  
Design Problems ◽  
Design Synthesis ◽  
Design Concepts ◽  
Topological Design ◽  
Functional Representation ◽  
Component Layout ◽  
Computational Design Synthesis ◽  
Function Sharing

This paper presents some key extensions to a representation for electromechanical components that is sufficiently detailed enough to provide for the automated construction of new design configurations. The extensions, shown here, build upon a representation that is both formal and implemented, and can handle the interactions between components even if such interactions represent only partial configurations. The results of these new additions elucidate the power and flexibility of this functional representation for electromechanical components. The method can be used as an interactive tool to allow an engineering designer to explore new design concepts or can be combined with additional software tools to achieve a computational design synthesis approach to topological design problems. The inclusion of function sharing, component layout, and qualitative dynamics achieve a closer approach to how the human mind represents components.

A Spatial Grammar Method for the Computational Design Synthesis of Virtual Soft Locomotion Robots

2019 ◽  
Vol 141 (10) ◽  
Author(s):  
Merel van Diepen ◽  
Kristina Shea
Keyword(s):  
Degrees Of Freedom ◽  
Computational Design ◽  
Simulation Method ◽  
Search Space ◽  
Search Process ◽  
Design Synthesis ◽  
Spatial Grammar ◽  
Three Stages ◽  
Computational Design Synthesis ◽  
Simulation Feedback

Soft locomotion robots are intrinsically compliant and have a large number of degrees of freedom. They lack rigid components that provide them with higher flexibility, and they have no joints that need protection from liquids or dirt. However, the hand-design of soft robots is often a lengthy trail-and-error process. This work presents the computational design of virtual, soft locomotion robots using an approach that integrates simulation feedback. The computational approach consists of three stages: (1) generation, (2) evaluation through simulation, and (3) optimization. Here, designs are generated using a spatial grammar to explicitly guide the type of solutions generated and exclude infeasible designs. The soft material simulation method developed and integrated is stable and sufficiently fast for use in a highly iterative simulated annealing search process. The resulting virtual designs exhibit a large variety of expected and unexpected gaits, thus demonstrating the method capabilities. Finally, the optimization results and the spatial grammar are analyzed to understand and map the challenges of the problem and the search space.

Automatically Transforming Object-Oriented Graph-Based Representations Into Boolean Satisfiability Problems for Computational Design Synthesis

2013 ◽  
Vol 135 (10) ◽  
Author(s):  
Clemens Münzer ◽  
Bergen Helms ◽  
Kristina Shea
Keyword(s):  
Space Exploration ◽  
Solution Space ◽  
Object Oriented ◽  
Computational Design ◽  
Building Blocks ◽  
Boolean Satisfiability ◽  
Design Synthesis ◽  
Alcohol Production ◽  
Systematic Solution ◽  
Computational Design Synthesis

Ever since computers have been used to support human designers, a variety of representations have been used to encapsulate engineering knowledge. Computational design synthesis (CDS) approaches utilize this knowledge to generate design candidates for a specified task. However, new approaches are required to enable systematic solution space exploration. This paper presents an approach that combines a graph-based object-oriented knowledge representation with first-order logic and Boolean satisfiability. This combination is used as the foundation for a generic automated approach for requirement-driven computational design synthesis. Available design building blocks and a design task defined through a set of requirements are modeled in a graph-based environment and then automatically transferred into a Boolean satisfiability problem and solved, considering a given solution size. The Boolean solution is automatically transferred back to the graph-based domain. The method is validated through two case studies: synthesis of automotive powertrains and chemical process synthesis for ethyl alcohol production. The contribution of the paper is a new method that is able to determine if an engineering task is solvable for a given set of synthesis building blocks and enables systematic solution space exploration.

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