Neuroimaging and Blood Biomarkers of Sport Concussion

2022 ◽  
pp. 207-216
Author(s):  
Ayobami L. Ward ◽  
Jacob R. Joseph
Keyword(s):  
Blood Biomarkers ◽  
Sport Concussion

scholarly journals Blood biomarkers are associated with brain function and blood flow following sport concussion

2018 ◽  
Vol 319 ◽  
pp. 1-8 ◽  
Author(s):  
Alex P. Di Battista ◽  
Nathan Churchill ◽  
Tom A. Schweizer ◽  
Shawn G. Rhind ◽  
Doug Richards ◽  
...  
Keyword(s):  
Blood Flow ◽  
Brain Function ◽  
Blood Biomarkers ◽  
Sport Concussion

Information about Sports Related Concussion and Return to Play Rules in Youth Soccer, Rugby and Handball on Websites of German Sports Clubs (Preprint)

2020 ◽  
Author(s):  
Laura Rihani ◽  
Jennifer Usinger ◽  
Nicola Jungbäck ◽  
Gabriele Stumm ◽  
Thorsten Schulz ◽  
...  
Keyword(s):  
Brain Injuries ◽  
Return To Play ◽  
Online Information ◽  
Lower Saxony ◽  
Systematic Analysis ◽  
Youth Soccer ◽  
Sports Clubs ◽  
Sport Concussion ◽  
The Usa ◽  
Sports Activities

BACKGROUND Sports-related mild traumatic brain injuries (sports related concussion, SRC) have received increasing attention since neurodegenerative processes have been linked to repetitive SRCs. Return-to-Play (RTP) rules have been established for medical advised return into sports activities after concussion, but it is not clear if these rules also reach the sports clubs and its young athletes. OBJECTIVE In youth sports, athletes and their parents search the internet for advice after SRC. We therefore investigated which websites of German sports associations and clubs in football (soccer), handball and rugby offer information on SRC and RTP rules. METHODS The systematic analysis included websites of local football, handball and rugby clubs in two comparable regions in Southern Bavaria and Lower Saxony. The websites of the regional and the German umbrella associations were also included into the study. Eight criteria of the revised Sport Concussion Consensus Statement served as standard for the evaluation according to the protocol published by Swallow et al. (J Neurosurg Pediatr, 2018). RESULTS No information on RTP rules or the topic “sports-related brain injuries” could be found on any of the clubs’ websites. Only the Bavarian Football Association and the Rugby Association sporadically provided information on the topic. The German umbrella associations in football and rugby take up international documents and regulations of the European and the world associations. No information could be found at the German Handball Association. CONCLUSIONS The topics of sports-related brain injuries and RTP rules are mostly neglected on the analysed Websites. This is remarkable, as there are clearly defined consensus guidelines which are widely accepted in international comparison. Especially in the USA, online information on this topic has become standard.

scholarly journals Knowledge and attitudes towards concussion in UK-based male ice hockey players: A need for attitude change?

2019 ◽  
Vol 14 (2) ◽  
pp. 153-161 ◽  
Author(s):  
Sarah Hutchinson ◽  
Paul Ellison ◽  
Andrew Levy ◽  
David Marchant
Keyword(s):  
Attitude Change ◽  
Ice Hockey ◽  
Knowledge And Attitudes ◽  
Accurate Knowledge ◽  
Hockey Players ◽  
Sport Concussion ◽  
Concussion History ◽  
Concussion Knowledge ◽  
The Uk

Objective Concussion is a common injury in ice hockey, and previous research suggests some misconceptions and unsafe attitudes amongst players. The purpose of this study was to assess sport concussion knowledge, attitudes and the effect of sport concussion history in UK-based male ice hockey players across three levels of competition: professional, semi-professional and amateur. Methods Sixty-one participants across a number of UK ice hockey teams completed the Rosenbaum Concussion Knowledge and Attitudes Survey and reviewed a series of statements to assess knowledge (concussion knowledge index), attitudes (concussion attitude index) and misconceptions of concussion. Results Level of competition and concussion history had no significant effect on concussion knowledge index or concussion attitude index. A positive significant relationship exists between playing experience and concussion knowledge index and concussion attitude index. Statements identified common misconceptions and areas of accurate knowledge regarding concussion symptoms suggesting that male ice hockey players have a higher level knowledge compared to a sample of the UK general public. Playing experience was associated with increased knowledge and increasingly safe attitudes towards concussion. Conclusion Despite knowledge relating to loss of consciousness and correct management of symptoms being generally accurate, there are worryingly unsafe attitudes regarding aspects of concussion. Such attitudes may well pose significant threats to players’ safety and long-term health.

scholarly journals SAT0415 AGE RELATIONSHIP WITH ULTRASOUND ARTICULAR AND ENTHESEAL INVOLVEMENT IN PSORIATIC ARTHRITIS: CROSS-SECTIONAL STUDY

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 1160.2-1161
Author(s):  
I. Fairushina ◽  
D. Abdulganieva ◽  
E. Kirillova ◽  
R. Abdrakipov
Keyword(s):  
Psoriatic Arthritis ◽  
Disease Activity ◽  
Power Doppler ◽  
Severity Index ◽  
Cross Sectional Study ◽  
Blood Biomarkers ◽  
Cross Sectional ◽  
Age Related ◽  
Hs Crp ◽  
Axial Involvement

Background:Detection of subclinical enthesitis and synovitis in psoriatic arthritis (PsA) is prevalent and ultrasound (US) examination is informative tool for it diagnosing. Aging positively affects degenerative changes.Objectives:To study relationship between US articular and entheseal findings with age in patients with PsA.Methods:57 patients were enrolled to study with fulfilled PsA criteria (CASPAR, 2009). Data collection: demographical, clinical (current psoriasis, axial involvement, enthesitis, dactylitis), US (synovitis count (by Grey Scale), Power Doppler(PD)+ synovitis), thickening and hypoechogenicity at enthesis, PD+ enthesitis, entheses with structural components); biological (high sensitive C-reactive protein (hsCRP), Erythrocyte Sedimentation Rate (ESR).US examination included 798 joints and 3078 entheses (bilateral shoulders, acromioclavicular joints, elbows, wrists, hips, knees, ankles; entheses at the projection of these joints (total number - 54). US entheseal findings were fixed according to consensus-based US definition and scoring for enthesitis in spondyloarthritis and PsA (OMERACT US)1.Results:In all 57 patients: male - 25 (43.9%), mean age 43.4±10.3(SD) years (y), PsA duration was 7 (3;10) y, Ps duration 10 (8; 22) y; 53 (41.1%) had axial involvement, 42 (73.7%) dactylitis, 8 (14%) clinical enthesitis, and 56 (98.2 %) skin psoriasis, Psoriasis Activity and Severity Index score 6.4 (2;14.4), Disease Activity in PsA score 18.1 (10.2;26.1), hsCRP 10.1(2.4;21.4), ESR 20 (11.3;31.5).Synovitis count increased with age noticeably (r=0.508, p<0.01), and weak correlation of PD+ synovitis (r=0.262, p=0.049) and age was found. The entheseal thickening and hypoechogenicity and structural findings increased with age respectively (r=0.345, p=0.009; r=0.337, p=0.01). There was no correlation between PD+ enthesitis and age. The assosiation between PD+ enthesitis and blood biomarkers of inflammation (hs-CRP (r=0.364, p=0.008); ESR (p=0.358, p=0.008) was found.Conclusion:Our study found significant relationship between age and US synovitis. Association between age and US entheseal involvement was noted. Only PD+ enthesitis was not related with age in comparison with other US entheseal findings. The presence of PD US signal at enthesitis in association with increased inflammatory blood biomarkers can be evaluated as the sign of disease activity regardless of age and not as age-related lesion in PsA patients.References:[1]Balint PV, Terslev L, Aegerter P et al. Reliability of a consensus-based ultrasound definition and scoring for enthesitis in spondyloarthritis and psoriatic arthritis: an OMERACT US initiative. Ann Rheum Dis.;2018;77(12):1730-1735.Disclosure of Interests:None declared

scholarly journals Distinct epigenetic signatures between adult-onset and late-onset depression

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Hirotaka Yamagata ◽  
Hiroyuki Ogihara ◽  
Koji Matsuo ◽  
Shusaku Uchida ◽  
Ayumi Kobayashi ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Bisulfite Sequencing ◽  
Clinical Symptoms ◽  
Late Onset ◽  
Adult Onset ◽  
Blood Biomarkers ◽  
Major Depressive ◽  
Genome Wide ◽  
Healthy Control ◽  
Epigenetic Signatures

AbstractThe heterogeneity of major depressive disorder (MDD) is attributed to the fact that diagnostic criteria (e.g., DSM-5) are only based on clinical symptoms. The discovery of blood biomarkers has the potential to change the diagnosis of MDD. The purpose of this study was to identify blood biomarkers of DNA methylation by strategically subtyping patients with MDD by onset age. We analyzed genome-wide DNA methylation of patients with adult-onset depression (AOD; age ≥ 50 years, age at depression onset < 50 years; N = 10) and late-onset depression (LOD; age ≥ 50 years, age at depression onset ≥ 50 years; N = 25) in comparison to that of 30 healthy subjects. The methylation profile of the AOD group was not only different from that of the LOD group but also more homogenous. Six identified methylation CpG sites were validated by pyrosequencing and amplicon bisulfite sequencing as potential markers for AOD in a second set of independent patients with AOD and healthy control subjects (N = 11). The combination of three specific methylation markers achieved the highest accuracy (sensitivity, 64%; specificity, 91%; accuracy, 77%). Taken together, our findings suggest that DNA methylation markers are more suitable for AOD than for LOD patients.

scholarly journals Blood biomarkers for differential diagnosis and early detection of pancreatic cancer

2021 ◽  
pp. 102193
Author(s):  
Fawaz N. Al-Shaheri ◽  
Mohamed S.S. Alhamdani ◽  
Andrea Bauer ◽  
Nathalia Giese ◽  
Markus W. Büchler ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Differential Diagnosis ◽  
Early Detection ◽  
Blood Biomarkers
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