Thiostrepton, a Natural Compound That Triggers Heat Shock Response and Apoptosis in Human Cancer Cells: A Proteomics Investigation

2014 ◽  
pp. 443-451 ◽  
Author(s):  
Cristinel Sandu ◽  
Armand G. Ngounou Wetie ◽  
Costel C. Darie ◽  
Hermann Steller
Keyword(s):  
Heat Shock ◽  
Cancer Cells ◽  
Heat Shock Response ◽  
Natural Compound ◽  
Human Cancer ◽  
Human Cancer Cells ◽  
Shock Response

scholarly journals Inhibiting Heat Shock Factor 1 in Human Cancer Cells with a Potent RNA Aptamer

PLoS ONE ◽  
2014 ◽  
Vol 9 (5) ◽  
pp. e96330 ◽  
Author(s):  
H. Hans Salamanca ◽  
Marc A. Antonyak ◽  
Richard A. Cerione ◽  
Hua Shi ◽  
John T. Lis
Keyword(s):  
Heat Shock ◽  
Cancer Cells ◽  
Human Cancer ◽  
Heat Shock Factor ◽  
Heat Shock Factor 1 ◽  
Rna Aptamer ◽  
Human Cancer Cells

Effect of Heat Shock Protein 90 (Hsp90) on Migration and Invasion of Human Cancer Cells in Vitro

2014 ◽  
Vol 157 (4) ◽  
pp. 476-478 ◽  
Author(s):  
A. V. Snigireva ◽  
V. V. Vrublevskaya ◽  
Yu. Yu. Skarga ◽  
Yu. V. Evdokimovskaya ◽  
O. S. Morenkov
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Cancer Cells ◽  
Human Cancer ◽  
Heat Shock Protein 90 ◽  
Migration And Invasion ◽  
Human Cancer Cells

scholarly journals Targeting Heat Shock Response to Sensitize Cancer Cells to Proteasome and Hsp90 Inhibitors

2006 ◽  
Vol 66 (3) ◽  
pp. 1783-1791 ◽  
Author(s):  
Nava Zaarur ◽  
Vladimir L. Gabai ◽  
John A. Porco ◽  
Stuart Calderwood ◽  
Michael Y. Sherman
Keyword(s):  
Heat Shock ◽  
Cancer Cells ◽  
Heat Shock Response ◽  
Hsp90 Inhibitors ◽  
Shock Response

scholarly journals Evodiamine inhibits both stem cell and non-stem-cell populations in human cancer cells by targeting heat shock protein 70

Theranostics ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 2932-2952
Author(s):  
Seung Yeob Hyun ◽  
Huong Thuy Le ◽  
Hye-Young Min ◽  
Honglan Pei ◽  
Yijae Lim ◽  
...  
Keyword(s):  
Stem Cell ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Cancer Cells ◽  
Heat Shock Protein 70 ◽  
Human Cancer ◽  
Cell Populations ◽  
Human Cancer Cells ◽  
Stem Cell Populations

scholarly journals Gambogic acid and gambogenic acid induce a thiol-dependent heat shock response and disrupt the interaction between HSP90 and HSF1 or HSF2

2021 ◽  
Author(s):  
Linda Pesonen ◽  
Sally Svartsjö ◽  
Viktor Bäck ◽  
Aurélie de Thonel ◽  
Valérie Mezger ◽  
...  
Keyword(s):  
Heat Shock ◽  
Cancer Cells ◽  
Heat Shock Response ◽  
Critical Role ◽  
Cell Types ◽  
Hsp90 Inhibitor ◽  
Gambogic Acid ◽  
Heat Shock Factor 1 ◽  
Dependent Manner ◽  
Shock Response

AbstractCancer cells rely on heat shock proteins (HSPs) for growth and survival. Especially HSP90 has multiple client proteins and plays a critical role in malignant transformation, and therefore different types of HSP90 inhibitors are being developed. The bioactive natural compound gambogic acid (GB) is a prenylated xanthone with antitumor activity and it has been proposed to function as an HSP90 inhibitor. However, there are contradicting reports whether GB induces a heat shock response (HSR), which is cytoprotective for cancer cells and therefore a potentially problematic feature for an anticancer drug. In this study, we show that GB and a structurally related compound, called gambogenic acid (GBA), induce a robust HSR, in a thiol-dependent manner. Using heat shock factor 1 (HSF1) or HSF2 knockout cells, we show that the GB or GBA-induced HSR is HSF1-dependent. Intriguingly, using closed form ATP-bound HSP90-mutants that can be co-precipitated with HSF1, a known facilitator of cancer, we show that also endogenous HSF2 binds to the HSP90-HSF1 complex. GB and GBA treatment disrupt the interaction between HSP90 and HSF1 and HSF2. Our study implies that these compounds should be used cautiously if developed for cancer therapies, since GB and its derivative GBA are strong inducers of the HSR, in multiple cell types, by involving the dissociation of a HSP90-HSF1-HSF2 complex.

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