The Added Value of Diffusion Tensor Imaging for Automated White Matter Hyperintensity Segmentation

2014 ◽  
pp. 45-53 ◽  
Author(s):  
Hugo J. Kuijf ◽  
Chantal M. W. Tax ◽  
L. Karlijn Zaanen ◽  
Willem H. Bouvy ◽  
Jeroen de Bresser ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
White Matter ◽  
Diffusion Tensor ◽  
Added Value ◽  
White Matter Hyperintensity

Deep white matter hyperintensity is associated with the dilation of perivascular space

2021 ◽  
pp. 0271678X2110022
Author(s):  
Peiyu Huang ◽  
Ruiting Zhang ◽  
Yeerfan Jiaerken ◽  
Shuyue Wang ◽  
Wenke Yu ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
White Matter ◽  
Interstitial Fluid ◽  
Diffusion Tensor ◽  
Free Water ◽  
Perivascular Space ◽  
White Matter Hyperintensity ◽  
Deep White Matter ◽  
Free Water Content ◽  
Tight Association

Understanding the pathophysiology of white matter hyperintensity (WMH) is necessary to reduce its harmfulness. Dilated perivascular space (PVS) had been found related to WMH. In the present study, we aimed to examine the topological connections between WMH and PVS, and to investigate whether increased interstitial fluid mediates the correlation between PVS and WMH volumes. One hundred and thirty-six healthy elder subjects were retrospectively included from a prospectively collected community cohort. Sub-millimeter T2 weighted and FLAIR images were acquired for assessing the association between PVS and WMH. Diffusion tensor imaging and free-water (FW) analytical methods were used to quantify white matter free water content, and to explore whether it mediates the PVS-WMH association. We found that most (89%) of the deep WMH lesions were spatially connected with PVS, exhibiting several interesting topological types. PVS and WMH volumes were also significantly correlated (r = 0.222, p < 0.001). FW mediated this association in the whole sample (β = 0.069, p = 0.037) and in subjects with relatively high WMH load (β = 0.118, p = 0.006). These findings suggest a tight association between PVS dilation and WMH formation, which might be linked by the impaired glymphatic drainage function and accumulated local interstitial fluid.

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