ApoA-I Mimetic Peptides and Diabetes

2015 ◽  
pp. 43-54
Author(s):  
Max Benson ◽  
Stephen J. Peterson ◽  
Parag Mehta ◽  
Nader G. Abraham
Keyword(s):  
Mimetic Peptides

scholarly journals Supramolecular Nanofibers from Collagen-Mimetic Peptides Bearing Various Aromatic Groups at N-Termini via Hierarchical Self-Assembly

2021 ◽  
Vol 22 (9) ◽  
pp. 4533
Author(s):  
Tomoyuki Koga ◽  
Shinya Kingetsu ◽  
Nobuyuki Higashi
Keyword(s):  
Self Assembly ◽  
Triple Helix ◽  
Wavelength Conversion ◽  
Nile Red ◽  
Tem Analysis ◽  
Mimetic Peptides ◽  
Collagen Mimetic Peptides ◽  
Potential Applications ◽  
Hydrophobic Molecule ◽  
Emission Behavior

Self-assembly of artificial peptides has been widely studied for constructing nanostructured materials, with numerous potential applications in the nanobiotechnology field. Herein, we report the synthesis and hierarchical self-assembly of collagen-mimetic peptides (CMPs) bearing various aromatic groups at the N-termini, including 2-naphthyl, 1-naphtyl, anthracenyl, and pyrenyl groups, into nanofibers. The CMPs (R-(GPO)n: n > 4) formed a triple helix structure in water at 4 °C, as confirmed via CD analyses, and their conformations were more stable with increasing hydrophobicity of the terminal aromatic group and peptide chain length. The resulting pre-organized triple helical CMPs showed diverse self-assembly into highly ordered nanofibers, reflecting their slight differences in hydrophobic/hydrophilic balance and configuration of aromatic templates. TEM analysis demonstrated that 2Np-CMPn (n = 6 and 7) and Py-CMP6 provided well-developed natural collagen-like nanofibers and An-CMPn (n = 5–7) self-assembled into rod-like micelle fibers. On the other hand, 2Np-CMP5 and 1Np-CMP6 were unable to form nanofibers under the same conditions. Furthermore, the Py-CMP6 nanofiber was found to encapsulate a guest hydrophobic molecule, Nile red, and exhibited unique emission behavior based on the specific nanostructure. In addition to the ability of CMPs to bind small molecules, their controlled self-assembly enables their versatile utilization in drug delivery and wavelength-conversion nanomaterials.

scholarly journals ApoA-I Mimetic Peptides with Differing Ability to Inhibit Atherosclerosis Also Exhibit Differences in Their Interactions with Membrane Bilayers

2006 ◽  
Vol 282 (3) ◽  
pp. 1980-1988 ◽  
Author(s):  
Shaila P. Handattu ◽  
David W. Garber ◽  
Dawn C. Horn ◽  
Donald W. Hughes ◽  
Bob Berno ◽  
...  
Keyword(s):  
Membrane Bilayers ◽  
Mimetic Peptides

scholarly journals Apolipoprotein A-I (apoA-I) and apoA-I mimetic peptides inhibit tumor development in a mouse model of ovarian cancer

2010 ◽  
Vol 107 (46) ◽  
pp. 19997-20002 ◽  
Author(s):  
F. Su ◽  
K. R. Kozak ◽  
S. Imaizumi ◽  
F. Gao ◽  
M. W. Amneus ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Mouse Model ◽  
Tumor Development ◽  
Apolipoprotein A ◽  
Mimetic Peptides

scholarly journals Effects of Surface-Bound Collagen-Mimetic Peptides on Macrophage Uptake and Immunomodulation

2020 ◽  
Vol 8 ◽  
Author(s):  
Andrew T. Rowley ◽  
Vijaykumar S. Meli ◽  
Natalie J. Wu-Woods ◽  
Esther Y. Chen ◽  
Wendy F. Liu ◽  
...  
Keyword(s):  
Mimetic Peptides ◽  
Collagen Mimetic Peptides ◽  
Macrophage Uptake

scholarly journals C-Terminus apoA-1 mimetic peptides to detect cognate auto-antibodies and reverse HIV-induced foam cell formation

2019 ◽  
Vol 2 (2) ◽  
Author(s):  
Nathalie Satta ◽  
Sabrina Pagano ◽  
Baris Gencer ◽  
Laurent Kaiser ◽  
Oliver Hartley ◽  
...  
Keyword(s):  
Foam Cell ◽  
Cell Formation ◽  
Foam Cell Formation ◽  
C Terminus ◽  
Mimetic Peptides
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