Validation and Calibration of Dietary Intake in Chronic Kidney Disease: An Ontological Approach

Author(s):  
Yu-Liang Chi ◽  
Tsang-Yao Chen ◽  
Wan-Ting Tsai
2020 ◽  
Vol 9 (1) ◽  
pp. 25-28
Author(s):  
Ashkan Salamatipour ◽  
Tina Moazezi ◽  
Suha Moten ◽  
Laurie Anne Berg ◽  
Anis Abdul Rauf

PLoS ONE ◽  
2019 ◽  
Vol 14 (10) ◽  
pp. e0223605 ◽  
Author(s):  
Susumu Ookawara ◽  
Yoshio Kaku ◽  
Kiyonori Ito ◽  
Kanako Kizukuri ◽  
Aiko Namikawa ◽  
...  

2017 ◽  
Vol 40 (5) ◽  
pp. 702-711 ◽  
Author(s):  
Gayle M. Timmerman ◽  
Muna J. Tahir ◽  
Richard M. Lewis ◽  
Deborah Samoson ◽  
Holli Temple ◽  
...  

Nutrients ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 3563
Author(s):  
Tung Hoang ◽  
Jeonghee Lee ◽  
Jeongseon Kim

The aim of this study was to elucidate the complex interrelationships among dietary intake, demographics, and the risk of comorbidities. We applied a Gaussian graphical model to calculate the dietary scores of the participants. The network structure of dietary intake, demographics, and comorbidities was estimated in a mixed graphical model. The centrality indices of the nodes (strength (S), closeness (C), and betweenness (B)) were measured to identify the central node. Multinomial logistic regression was used to examine the association between the factors and comorbidities. Among 7423 participants, the strongest pairwise interactions were found between sex and smoking (1.56), sex and employment (0.66), sex and marital status (0.58), marital status and income (0.65), and age and employment (0.58). Among the factors in the network, sex played a central role (S = 4.63, C = 0.014, B = 41), followed by age (S = 2.81, C = 0.013, B = 18), smoking (S = 2.72, C = 0.013, B = 0), and employment (S = 2.17, C = 0.014, B = 22). While the odds of hypertension and diseases were significantly higher among females than males, an inverse association was observed between high cholesterol and moderate chronic kidney disease. Among these factors, dietary intake was not a strongly interacting factor in the network, whereas age was consistently associated with the comorbidities of hypertension, high cholesterol, diabetes, and chronic kidney disease.


2020 ◽  
Vol 120 (7) ◽  
pp. 1151-1162.e3 ◽  
Author(s):  
Jessica M. Madrigal ◽  
Esteban Cedillo-Couvert ◽  
Ana C. Ricardo ◽  
Lawrence J. Appel ◽  
Cheryl A.M. Anderson ◽  
...  

BMJ Open ◽  
2015 ◽  
Vol 5 (3) ◽  
pp. e006897-e006897 ◽  
Author(s):  
S. C. Palmer ◽  
M. Ruospo ◽  
K. L. Campbell ◽  
V. Garcia Larsen ◽  
V. Saglimbene ◽  
...  

Nutrients ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 1234
Author(s):  
Maria Cappuccilli ◽  
Camilla Bergamini ◽  
Floriana A. Giacomelli ◽  
Giuseppe Cianciolo ◽  
Gabriele Donati ◽  
...  

Cardiovascular morbidity and mortality are several-fold higher in patients with advanced chronic kidney disease (CKD) and end-stage renal disease (ESRD) than in the general population. Hyperhomocysteinemia has undoubtedly a central role in such a prominent cardiovascular burden. The levels of homocysteine are regulated by methyl donors (folate, methionine, choline, betaine), and cofactors (vitamin B6, vitamin B12,). Uremia-induced hyperhomocysteinemia has as its main targets DNA methyltransferases, and this leads to an altered epigenetic control of genes regulated through methylation. In renal patients, the epigenetic landscape is strictly correlated with the uremic phenotype and dependent on dietary intake of micronutrients, inflammation, gut microbiome, inflammatory status, oxidative stress, and lifestyle habits. All these factors are key contributors in methylome maintenance and in the modulation of gene transcription through DNA hypo- or hypermethylation in CKD. This is an overview of the epigenetic changes related to DNA methylation in patients with advanced CKD and ESRD. We explored the currently available data on the molecular dysregulations resulting from altered gene expression in uremia. Special attention was paid to the efficacy of B-vitamins supplementation and dietary intake of methyl donors on homocysteine lowering and cardiovascular protection.


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