Role of Nerve Growth Factor Signaling in Cancer Cell Proliferation and Survival Using a Reachability Analysis Approach

2016 ◽  
pp. 173-181 ◽  
Author(s):  
Gustavo Santos-García ◽  
Carolyn Talcott ◽  
Adrián Riesco ◽  
Beatriz Santos-Buitrago ◽  
Javier De Las Rivas
Keyword(s):  
Cell Proliferation ◽  
Nerve Growth Factor ◽  
Growth Factor ◽  
Cancer Cell ◽  
Reachability Analysis ◽  
Analysis Approach ◽  
Growth Factor Signaling ◽  
Cancer Cell Proliferation ◽  
Nerve Growth

scholarly journals Effect of nerve growth factor on the proliferation in newborn bovine testicular Sertoli cells

Reproduction ◽  
2020 ◽  
Vol 160 (3) ◽  
pp. 405-415
Author(s):  
Qiaoge Niu ◽  
Maosheng Cao ◽  
Chenfeng Yuan ◽  
Yuwen Huang ◽  
Zijiao Zhao ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Nerve Growth Factor ◽  
Growth Factor ◽  
Signaling Pathways ◽  
Molecular Mechanisms ◽  
Male Reproduction ◽  
Nerve Growth ◽  
And Function

Nerve growth factor (NGF) has been proved to play important roles in male reproductive physiology, but the molecular mechanisms of NGF action remain unclear. In this study, the effects of NGF on the growth of newborn bovine testicular Sertoli (NBS) cells and the related signaling pathways were investigated. The NBS cells were treated in vitro with NGF (100 ng/mL) for 18 h. The expression levels of cell proliferation related genes, INHBB, and cytoplasmic specialization related gene were determined using real-time PCR and Western blot. The roles of PI3K/AKT and MAPK/ERK pathways in NGF-induced cell proliferation were investigated. It was found that NGF regulates proliferation and function of NBS cells via its receptor NTRK1 by activating the PI3K/ATK and MAPK/ERK signaling pathways. The study will help to further understand the role of NGF in male reproduction and provide new therapeutic targets for reproductive dysfunctions in male animals.

scholarly journals The statistical mechanics of complex signaling networks: nerve growth factor signaling

2004 ◽  
Vol 1 (3) ◽  
pp. 184-195 ◽  
Author(s):  
K S Brown ◽  
C C Hill ◽  
G A Calero ◽  
C R Myers ◽  
K H Lee ◽  
...  
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Statistical Mechanics ◽  
Signaling Networks ◽  
Growth Factor Signaling ◽  
Nerve Growth ◽  
Complex Signaling
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