Adaptation to partial urethral obstruction in healthy aging LOU rats and the role of nerve growth factor signaling pathway in the bladder

2021 ◽  
pp. 111625
Author(s):  
Abubakr Mossa ◽  
Philippe G. Cammisotto ◽  
Monica Velasquez-Flores ◽  
Lysanne Campeau
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Signaling Pathway ◽  
Healthy Aging ◽  
Urethral Obstruction ◽  
Growth Factor Signaling ◽  
Nerve Growth ◽  
Growth Factor Signaling Pathway

scholarly journals Peroxisome Proliferator-activated Receptor γ Is a Novel Target of the Nerve Growth Factor Signaling Pathway in PC12 Cells

2005 ◽  
Vol 280 (10) ◽  
pp. 9604-9609 ◽  
Author(s):  
Karen M. Fuenzalida ◽  
Mauricio C. Aguilera ◽  
Daniela G. Piderit ◽  
Patricio C. Ramos ◽  
David Contador ◽  
...  
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Signaling Pathway ◽  
Pc12 Cells ◽  
Peroxisome Proliferator ◽  
Growth Factor Signaling ◽  
Peroxisome Proliferator Activated Receptor ◽  
Nerve Growth ◽  
Novel Target ◽  
Growth Factor Signaling Pathway

scholarly journals v-Crk, an effector of the nerve growth factor signaling pathway, delays apoptotic cell death in neurotrophin-deprived PC12 cells

1996 ◽  
Vol 4 (1) ◽  
pp. 82-93 ◽  
Author(s):  
Robert H Glassman ◽  
Barbara L Hempstead ◽  
Lisa Staiano-Coico ◽  
Melissa G Steiner ◽  
Hidesaburo Hanafusa ◽  
...  
Keyword(s):  
Cell Death ◽  
Nerve Growth Factor ◽  
Growth Factor ◽  
Signaling Pathway ◽  
Pc12 Cells ◽  
Apoptotic Cell ◽  
Apoptotic Cell Death ◽  
Growth Factor Signaling ◽  
Nerve Growth ◽  
Growth Factor Signaling Pathway

scholarly journals Acceleration of TAA-Induced Liver Fibrosis by Stress Exposure Is Associated with Upregulation of Nerve Growth Factor and Glycopattern Deviations

2021 ◽  
Vol 22 (10) ◽  
pp. 5055
Author(s):  
Catalina Atorrasagasti ◽  
Flavia Piccioni ◽  
Sophia Borowski ◽  
Irene Tirado-González ◽  
Nancy Freitag ◽  
...  
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Liver Fibrosis ◽  
Signaling Pathway ◽  
Liver Damage ◽  
Neurotrophin Receptor ◽  
P75 Neurotrophin Receptor ◽  
Nerve Growth ◽  
Fibrotic Process ◽  
Ngf Signaling

Liver fibrosis results from many chronic injuries and may often progress to cirrhosis and hepatocellular carcinoma (HCC). In fact, up to 90% of HCC arise in a cirrhotic liver. Conversely, stress is implicated in liver damage, worsening disease outcome. Hence, stress could play a role in disrupting liver homeostasis, a concept that has not been fully explored. Here, in a murine model of TAA-induced liver fibrosis we identified nerve growth factor (NGF) to be a crucial regulator of the stress-induced fibrogenesis signaling pathway as it activates its receptor p75 neurotrophin receptor (p75NTR), increasing liver damage. Additionally, blocking the NGF decreased liver fibrosis whereas treatment with recombinant NGF accelerated the fibrotic process to a similar extent than stress challenge. We further show that the fibrogenesis induced by stress is characterized by specific changes in the hepatoglycocode (increased β1,6GlcNAc-branched complex N-glycans and decreased core 1 O-glycans expression) which are also observed in patients with advanced fibrosis compared to patients with a low level of fibrosis. Our study facilitates an understanding of stress-induced liver injury and identify NGF signaling pathway in early stages of the disease, which contributes to the established fibrogenesis.

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