Heat Shock Protein A2 (HSPA2): Regulatory Roles in Germ Cell Development and Sperm Function

2017 ◽  
pp. 67-93 ◽  
Author(s):  
Brett Nixon ◽  
Elizabeth G. Bromfield ◽  
Jinwei Cui ◽  
Geoffry N. De Iuliis
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Germ Cell ◽  
Cell Development ◽  
Sperm Function ◽  
Germ Cell Development

scholarly journals Cryptic genetic variation in a heat shock protein modifies the outcome of a mutation affecting epidermal stem cell development in C. elegans

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Sneha L. Koneru ◽  
Mark Hintze ◽  
Dimitris Katsanos ◽  
Michalis Barkoulas
Keyword(s):  
Genetic Variation ◽  
Stem Cell ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Cell Fate ◽  
Cell Development ◽  
Wnt Signalling ◽  
Single Amino Acid ◽  
Cryptic Genetic Variation ◽  
Seam Cell

AbstractA fundamental question in medical genetics is how the genetic background modifies the phenotypic outcome of mutations. We address this question by focusing on the seam cells, which display stem cell properties in the epidermis of Caenorhabditis elegans. We demonstrate that a putative null mutation in the GATA transcription factor egl-18, which is involved in seam cell fate maintenance, is more tolerated in the CB4856 isolate from Hawaii than the lab reference strain N2 from Bristol. We identify multiple quantitative trait loci (QTLs) underlying the difference in phenotype expressivity between the two isolates. These QTLs reveal cryptic genetic variation that reinforces seam cell fate through potentiating Wnt signalling. Within one QTL region, a single amino acid deletion in the heat shock protein HSP-110 in CB4856 is sufficient to modify Wnt signalling and seam cell development, highlighting that natural variation in conserved heat shock proteins can shape phenotype expressivity.

scholarly journals Upregulated lncRNA Gm2044 inhibits male germ cell development by acting as miR-202 host gene

2019 ◽  
Vol 23 (2) ◽  
pp. 128-134 ◽  
Author(s):  
Meng Liang ◽  
Ke Hu ◽  
Chaofan He ◽  
Jinzhao Zhou ◽  
Yaping Liao
Keyword(s):  
Germ Cell ◽  
Cell Development ◽  
Host Gene ◽  
Male Germ Cell ◽  
Germ Cell Development

scholarly journals Human-specific subcellular compartmentalization of P-element induced wimpy testis-like (PIWIL) granules during germ cell development and spermatogenesis

2017 ◽  
Vol 33 (2) ◽  
pp. 258-269 ◽  
Author(s):  
Maria Gomes Fernandes ◽  
Nannan He ◽  
Fang Wang ◽  
Liesbeth Van Iperen ◽  
Cristina Eguizabal ◽  
...  
Keyword(s):  
Germ Cell ◽  
Cell Development ◽  
P Element ◽  
Germ Cell Development ◽  
Subcellular Compartmentalization ◽  
Human Specific

scholarly journals Persistent Requirement and Alteration of the Key Targets of PRDM1 During Primordial Germ Cell Development in Mice1

2016 ◽  
Vol 94 (1) ◽  
Author(s):  
Chika Yamashiro ◽  
Takayuki Hirota ◽  
Kazuki Kurimoto ◽  
Tomonori Nakamura ◽  
Yukihiro Yabuta ◽  
...  
Keyword(s):  
Germ Cell ◽  
Primordial Germ Cell ◽  
Cell Development ◽  
Germ Cell Development

Germ cell-specific heat shock protein 70-2 is expressed in cervical carcinoma and is involved in the growth, migration, and invasion of cervical cells

Cancer ◽  
2010 ◽  
Vol 116 (16) ◽  
pp. 3785-3796 ◽  
Author(s):  
Manoj Garg ◽  
Deepika Kanojia ◽  
Shikha Saini ◽  
Sushma Suri ◽  
Anju Gupta ◽  
...  
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Germ Cell ◽  
Specific Heat ◽  
Cervical Carcinoma ◽  
Heat Shock Protein 70 ◽  
Migration And Invasion ◽  
Cervical Cells
Sign in / Sign up

Export Citation Format

Share Document