Handling Missing Data in Observational Clinical Studies Concerning Cardiovascular Risk: An Insight into Critical Aspects

2017 ◽  
pp. 175-188
Author(s):  
Nadia Solaro ◽  
Daniela Lucini ◽  
Massimo Pagani
Keyword(s):  
Cardiovascular Risk ◽  
Missing Data ◽  
Clinical Studies ◽  
Insight Into ◽  
Critical Aspects

scholarly journals Missing Data in Clinical Studies

2021 ◽  
Author(s):  
Amit K. Chowdhry ◽  
Vinai Gondi ◽  
Stephanie L. Pugh
Keyword(s):  
Missing Data ◽  
Clinical Studies

scholarly journals Gender peculiarities of interrelations between cardiovascular risk factors and development of prehypertension

2018 ◽  
pp. 57-63
Author(s):  
В.В. Шерстнёв ◽  
М.А. Грудень ◽  
О.В. Сенько ◽  
В.П. Карлина ◽  
А.В. Кузнецова ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Left Ventricular ◽  
Drug Prevention ◽  
Cardiovascular Morbidity And Mortality ◽  
Prevention Of Hypertension ◽  
The Relationship ◽  
Insight Into ◽  
Qualitative Changes

В настоящее время доказано, что предгипертензия, характеризующая состояние лиц с артериальным давлением (АД) от 120/80 мм рт.ст. до 139/89 мм рт.ст., имеет высокую и постоянно возрастающую распространенность среди населения во всем мире и является независимым фактором риска формирования артериальной гипертонии, развития сердечно-сосудистой заболеваемости и смертности. Это делает актуальным изучение взаимосвязи развития предгипертензии с наличием других факторов риска сердечно-сосудистых заболеваний. Целью данного исследования явилось изучение гендерных особенностей взаимосвязи факторов риска сердечно-сосудистых заболеваний и развития предгипертензии. Методы исследования. Проведен сравнительный и корреляционный анализ показателей модифицируемых и немодифицируемых факторов риска сердечно-сосудистых заболеваний у 115 обследованных лиц мужского (n = 49) и женского пола (n = 66), средний возраст которых составил 47,6 ± 0,7 года с оптимальным АД (n = 63, АД < 120/80 мм рт.ст.) и предгипертензией (n = 52, АД 120-139/80-89 мм рт.ст.). Результаты исследования. Обнаружено, что мужчины и женщины с оптимальным АД и с предгипертензией различаются спектром факторов риска и структурой взаимосвязи исследованных показателей. У мужчин предгипертензия ассоциирована с повышенным содержанием креатинина в крови и табакокурением, тогда как у женщин - с гипертрофией левого желудочка сердца, стрессом и наследственной отягощенностью по гипертонической болезни. Развитие предгипертензии у женщин по сравнению с мужчинами характеризуется более выраженными количественными и качественными изменениями структуры взаимосвязей показателей исследованных факторов риска сердечно-сосудистых заболеваний. Заключение. Полученные результаты представляют интерес для понимания механизмов патогенеза предгипертензии и разработки стратегии её персонифицированной немедикаментозной и медикаментозной профилактики, основанной на устранении или ослаблении определенных факторов риска сердечно-сосудистых заболеваний. Currently it is proved that prehypertension characterizing the condition of individuals with blood pressure (BP) from 120/80 mm Hg to 139/89 mm Hg has a high, continuously increasing prevalence worldwide and is an independent risk factor for development of arterial hypertension and cardiovascular morbidity and mortality, which justifies studying the relationship between prehypertension and the presence of other risk factors for cardiovascular diseases. The aim of this study was to investigate gender features of the relationship between risk factors for cardiovascular disease and development of prehypertension. Methods. Comparative and correlation analyses of modifiable and non-modifiable cardiovascular risk factors were performed for 115 males (n = 49) and females (n = 66) aged 47.6 ± 0.7 with optimal BP (n = 63, BP < 120/80 mm Hg) or prehypertension (n = 52, AD = 120-139/80-89 mm Hg). Results. Men and women with optimal BP and prehypertension differed in the array of risk factors and the structure of relationship between the studied indices. In men, prehypertension was associated with an elevated blood creatinine and tobacco smoking whereas in women - with left ventricular hypertrophy, stress, and hereditary burden of hypertension. The development of prehypertension in women compared to men was characterized by more pronounced quantitative and qualitative changes in the structure of interrelationships between indices of the studied cardiovascular risk factors. Conclusion. The obtained results provide insight into pathogenetic mechanisms of prehypertension. They can be used for developing a strategy for individualized non-drug and drug prevention of hypertension based on elimination or reduction of certain cardiovascular risk factors.

Missing Data Estimation Using Rough Sets

2010 ◽  
pp. 94-116
Author(s):  
Tshilidzi Marwala
Keyword(s):  
Missing Data ◽  
Rough Set ◽  
Rough Sets ◽  
Real Data ◽  
Valuable Insight ◽  
Lower And Upper Approximations ◽  
Decision Tables ◽  
Missing Data Estimation ◽  
Data Estimation ◽  
Insight Into

A number of techniques for handling missing data have been presented and implemented. Most of these proposed techniques are unnecessarily complex and, therefore, difficult to use. This chapter investigates a hot-deck data imputation method, based on rough set computations. In this chapter, characteristic relations are introduced that describe incompletely specified decision tables and then these are used for missing data estimation. It has been shown that the basic rough set idea of lower and upper approximations for incompletely specified decision tables may be defined in a variety of different ways. Empirical results obtained using real data are given and they provide a valuable insight into the problem of missing data. Missing data are predicted with an accuracy of up to 99%.

Assessment of cardiovascular risk in type 2 diabetes patients by insight into radial pulse wave harmonic index

2019 ◽  
Vol 228 (1) ◽  
Author(s):  
Kuo‐Meng Liao ◽  
Chi‐Wei Chang ◽  
Sheng‐Hung Wang ◽  
Yi‐Ting Chang ◽  
Ying‐Chun Chen ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Cardiovascular Risk ◽  
Pulse Wave ◽  
Radial Pulse ◽  
Harmonic Index ◽  
Insight Into ◽  
Diabetes Patients

Missing Data in Clinical Studies by MOLENBERGHS, G. and KENWARD, M. G.

Biometrics ◽  
2009 ◽  
Vol 65 (3) ◽  
pp. 993-994
Author(s):  
Suzanne R. Dubnicka
Keyword(s):  
Missing Data ◽  
Clinical Studies

Translational insight into statin-induced muscle toxicity: from cell culture to clinical studies

2014 ◽  
Vol 164 (2) ◽  
pp. 85-109 ◽  
Author(s):  
Dhiaa A. Taha ◽  
Cornelia H. De Moor ◽  
David A. Barrett ◽  
Pavel Gershkovich
Keyword(s):  
Cell Culture ◽  
Clinical Studies ◽  
Muscle Toxicity ◽  
Insight Into

A Procedure for Computation of Fully Stalled Flows in Two-Dimensional Passages

1978 ◽  
Vol 100 (2) ◽  
pp. 180-186 ◽  
Author(s):  
R. L. Woolley ◽  
S. J. Kline
Keyword(s):  
Boundary Layers ◽  
Turbulent Boundary Layers ◽  
Separated Flows ◽  
Two Dimensional ◽  
Design Problems ◽  
Zonal Model ◽  
Pressure Distributions ◽  
Insight Into ◽  
Critical Aspects ◽  
Two Dimensional Flows

A procedure is described for computation of incompressible, steady, two-dimensional flows in fully-stalled diffusers with plenum exit. The procedure is successful in predicting pressure distributions and patterns to the accuracy of the data. The procedure employs a zonal model; this maintains close connections between the modeling and the physics thereby providing insight into critical aspects of modeling separated flows. The procedure presented is also convenient for computing unstalled flows in passages with turbulent boundary layers for either direct or indirect design problems. Computing times are well within engineering feasibility. The concepts developed can be extended to other classes of separated flows; some of these extensions have already been completed and are referenced.

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