Production and Genetic Engineering of Terpenoids Production in Plant Cell and Organ Cultures

2013 ◽  
pp. 2761-2796 ◽  
Author(s):  
Mercedes Bonfill ◽  
Sonia Malik ◽  
M. Hossein Mirjalili ◽  
Marta Goleniowski ◽  
Rosa Cusido ◽  
...  
Keyword(s):  
Genetic Engineering ◽  
Plant Cell ◽  
Organ Cultures

scholarly journals Methyl Jasmonate Induced Oxidative Stress and Accumulation of Secondary Metabolites in Plant Cell and Organ Cultures

2020 ◽  
Vol 21 (3) ◽  
pp. 716 ◽  
Author(s):  
Thanh-Tam Ho ◽  
Hosakatte Niranjana Murthy ◽  
So-Young Park
Keyword(s):  
Secondary Metabolites ◽  
Methyl Jasmonate ◽  
Plant Cell ◽  
Large Scale ◽  
Cultured Cells ◽  
Food Additives ◽  
Plant Secondary Metabolites ◽  
Signal Molecules ◽  
Scale Production ◽  
Organ Cultures

Recently, plant secondary metabolites are considered as important sources of pharmaceuticals, food additives, flavours, cosmetics, and other industrial products. The accumulation of secondary metabolites in plant cell and organ cultures often occurs when cultures are subjected to varied kinds of stresses including elicitors or signal molecules. Application of exogenous jasmonic acid (JA) and methyl jasmonate (MJ) is responsible for the induction of reactive oxygen species (ROS) and subsequent defence mechanisms in cultured cells and organs. It is also responsible for the induction of signal transduction, the expression of many defence genes followed by the accumulation of secondary metabolites. In this review, the application of exogenous MJ elicitation strategies on the induction of defence mechanism and secondary metabolite accumulation in cell and organ cultures is introduced and discussed. The information presented here is useful for efficient large-scale production of plant secondary metabolites by the plant cell and organ cultures.

The safety assessment of food ingredients derived from plant cell, tissue and organ cultures: A review

2015 ◽  
Vol 176 ◽  
pp. 426-432 ◽  
Author(s):  
Hosakatte Niranjana Murthy ◽  
Milen I. Georgiev ◽  
So-Young Park ◽  
Vijayalaxmi S. Dandin ◽  
Kee-Yoeup Paek
Keyword(s):  
Plant Cell ◽  
Safety Assessment ◽  
Organ Cultures ◽  
Food Ingredients ◽  
Cell Tissue

scholarly journals Sekonder Bitki Metabolitlerinin In Vitro Koşullarda Üretimi

2019 ◽  
Vol 7 (7) ◽  
pp. 971
Author(s):  
Tuncay Çalışkan ◽  
Rüştü Hatipoğlu ◽  
Saliha Kırıcı
Keyword(s):  
Secondary Metabolites ◽  
Secondary Metabolite ◽  
Plant Cell ◽  
Abiotic Factors ◽  
Food Additives ◽  
Plant Secondary Metabolites ◽  
Secondary Metabolite Production ◽  
Organ Cultures ◽  
Metabolite Production

Plant secondary metabolites are a group of organic compounds produced by plants to interact with biotic and abiotic factors and for the establishment of defence mechanism. Secondary metabolites are classified based on their biosynthetic origin and chemical structure. They have been used as pharmaceutical, agrochemical, flavours, fragrances, colours and food additives. Secondary metabolites are traditionally produced from the native grown or field grown plants. However, this conventional approach has some disadvantages such as low yield, instability of secondary metabolite contents of the plants due to geographical, seasonal and environmental variations, need for land and heavy labour to grow plants. Therefore, plant cell and organ cultures have emerged as an alternative to plant growing under field conditions for secondary metabolite production. In this literature review, present state of secondary metabolite production through plant cell and organ cultures, its problems as well as solutions of the problems were discussed.

Biotechnological Production of Pharmaceuticals and Biopharmaceuticals in Plant Cell and Organ Cultures

2018 ◽  
Vol 25 (30) ◽  
pp. 3577-3596 ◽  
Author(s):  
Diego Hidalgo ◽  
Raul Sanchez ◽  
Liliana Lalaleo ◽  
Mercedes Bonfill ◽  
Purificacion Corchete ◽  
...  
Keyword(s):  
Metabolic Engineering ◽  
Plant Cell ◽  
Organ Cultures ◽  
Biotechnological Production ◽  
Metabolic Genes ◽  
Plant Biofactories ◽  
Industrial Level ◽  
Specific Reactions ◽  
New Applications ◽  
Pharmaceutical Production

Background: Plant biofactories are biotechnological platforms based on plant cell and organ cultures used for the production of pharmaceuticals and biopharmaceuticals, although to date only a few of these systems have successfully been implemented at an industrial level. Metabolic engineering is possibly the most straightforward strategy to boost pharmaceutical production in plant biofactories, but social opposition to the use of GMOs means empirical approaches are still being used. <P><P> Plant secondary metabolism involves thousands of different enzymes, some of which catalyze specific reactions, giving one product from a particular substrate, whereas others can yield multiple products from the same substrate. This trait opens plant cell biofactories to new applications, in which the natural metabolic machinery of plants can be harnessed for the bioconversion of phytochemicals or even the production of new bioactive compounds. Synthetic biological pipelines involving the bioconversion of natural substrates into products with a high market value may be established by the heterologous expression of target metabolic genes in model plants. <P><P> Objective: To summarize the state of the art of plant biofactories and their applications for the pipeline production of cosme-, pharma- and biopharmaceuticals. <P><P> Results: In order to demonstrate the great potential of plant biofactories for multiple applications in the biotechnological production of pharmaceuticals and biopharmaceuticals, this review broadly covers the following: plant biofactories based on cell and hairy root cultures; secondary metabolite production; biotransformation reactions; metabolic engineering tools applied in plant biofactories; and biopharmaceutical production.

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