The MYST Family of Histone Acetyltransferases

2003 ◽  
pp. 203-236 ◽  
Author(s):  
R. T. Utley ◽  
J. Côté
Keyword(s):  
Histone Acetyltransferases

scholarly journals Discovery of Spirohydantoins as Selective, Orally Bioavailable Inhibitors of p300/CBP Histone Acetyltransferases

2021 ◽  
pp. 127854
Author(s):  
Zhiqin Ji ◽  
Richard F. Clark ◽  
Vikram Bhat ◽  
T. Matthew Hansen ◽  
Loren M. Lasko ◽  
...  
Keyword(s):  
Histone Acetyltransferases ◽  
Orally Bioavailable

scholarly journals Histone Acetyltransferases and Stem Cell Identity

Cancers ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 2407
Author(s):  
Ruicen He ◽  
Arthur Dantas ◽  
Karl Riabowol
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Cell Fate ◽  
Epigenetic Modification ◽  
Cell Types ◽  
Histone Acetyltransferases ◽  
Specific Cell ◽  
Cell Fates ◽  
Cell Identity ◽  
Hematopoietic Stem

Acetylation of histones is a key epigenetic modification involved in transcriptional regulation. The addition of acetyl groups to histone tails generally reduces histone-DNA interactions in the nucleosome leading to increased accessibility for transcription factors and core transcriptional machinery to bind their target sequences. There are approximately 30 histone acetyltransferases and their corresponding complexes, each of which affect the expression of a subset of genes. Because cell identity is determined by gene expression profile, it is unsurprising that the HATs responsible for inducing expression of these genes play a crucial role in determining cell fate. Here, we explore the role of HATs in the maintenance and differentiation of various stem cell types. Several HAT complexes have been characterized to play an important role in activating genes that allow stem cells to self-renew. Knockdown or loss of their activity leads to reduced expression and or differentiation while particular HATs drive differentiation towards specific cell fates. In this study we review functions of the HAT complexes active in pluripotent stem cells, hematopoietic stem cells, muscle satellite cells, mesenchymal stem cells, neural stem cells, and cancer stem cells.

Small Molecule Inhibitors of Histone Acetyltransferases as Epigenetic Tools and Drug Candidates

2011 ◽  
Vol 345 (1) ◽  
pp. 7-21 ◽  
Author(s):  
Silviya D. Furdas ◽  
Srinivasaraghavan Kannan ◽  
Wolfgang Sippl ◽  
Manfred Jung
Keyword(s):  
Small Molecule ◽  
Small Molecule Inhibitors ◽  
Histone Acetyltransferases ◽  
Drug Candidates

scholarly journals Effects of H3 and H4 Histones Acetylation and Bindings of CREB Binding Protein and p300 at the Promoter on Hepatic Expression of γ-glutamyltransferase Gene in a Streptozotocin-Induced Moderate Hypoinsulinemic Rat Model

2021 ◽  
pp. 475-480
Author(s):  
T TANAKA ◽  
T MIZUNO ◽  
T NAKAGAWA ◽  
T HAYAKAWA ◽  
M SHIMADA
Keyword(s):  
Insulin Secretion ◽  
Rat Model ◽  
Binding Protein ◽  
Histone Acetyltransferases ◽  
Creb Binding Protein ◽  
Concerted Effort ◽  
Promoter Regions ◽  
Gamma Glutamyltransferase ◽  
Hepatic Expression ◽  
Increased Risk

Gamma-glutamyltransferase (GGT), a marker of liver disease, has been shown to be associated with increased risk of diabetes and relative insulin secretion deficiency. However, the mechanism of hepatic Ggt regulation has not been explored fully. In this study, we made a concerted effort to understand the mechanism by investigating the effects of acetylation of histones H3 and H4, and bindings of histone acetyltransferases, CREB binding protein (CBP) and p300, at the Ggt promoter on the regulation of the expression of Ggt gene in the livers of streptozotocin (STZ)-induced moderate hypoinsulinemia rat model. The rats treated with STZ showed remarkably higher serum GGT level and hepatic Ggt/GGT expression than the untreated control rats. Furthermore, the acetylation of histones H3 and H4, and the binding of CBP not p300 at the Ggt promoter regions were significantly higher in the livers of STZ rats than those of the control rats. These results suggest that an enhanced hepatic expression of Ggt is associated with increased acetylation of histones H3 and H4 and CBP binding at the Ggt promoter in STZ-induced moderate hypoinsulinemic rats.

Sign in / Sign up

Export Citation Format

Share Document